Michigan Wolverines vs USC Trojans Prediction & Picks - NCAA

USA - NCAA

Michigan Wolverines
10/11/25 19:30
USC Trojans

Prediction:

 

Michigan Wolverines +3.5 Alternate Spread

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 by Matt Lowrimore | in NCAA Picks

Another one of the games on the Week 7 Saturday college football schedule will see the 15th-ranked Michigan Wolverines take on the USC Trojans in the Big Ten. Let’s take a look at the match statistics and predictions for this game between the Trojans and the Wolverines.

Michigan enters this game with a record of 4-1 and 2-0 in the Big Ten. The Wolverines most recently beat the Wisconsin Badgers in Week 6 by a score of 24-10. Michigan’s offense had a total of 445 yards, while its defense allowed 252 yards. Quarterback Bryce Underwood threw for 270 yards and one touchdown, while running back Justice Haynes led the team in rushing with 117 yards and two touchdowns.

As for USC, they enter this game with a record of 4-1 and 2-1 in the Big Ten. The Trojans most recently lost to the Illinois Fighting Illini in Week 5 by a score of 34-32. USC’s offense had a total of 490 yards, while its defense allowed 502 yards. Quarterback Jayden Maiava threw for 364 yards, two touchdowns, and one interception, while running back Waymond Jordan led the team in rushing with 92 yards and two touchdowns.

Michigan Wolverines vs USC Trojans Form

Table

Teams % P W D L
4
Michigan Wolverines
Michigan Wolverines
0.778 9 7 0 2
5
USC Trojans
USC Trojans
0.778 9 7 0 2

Michigan Wolverines and USC Trojans Latest Matches

Michigan Wolverines
Michigan Wolverines Latest matches
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 4, 2025 - NCAA

Wisconsin Badgers
10 :  24
Michigan Wolverines

Sep 20, 2025 - NCAA

Michigan Wolverines
30 :  27
Nebraska Cornhuskers

Sep 13, 2025 - NCAA

Central Michigan Chippewas
3 :  63
Michigan Wolverines

Sep 6, 2025 - NCAA

Michigan Wolverines
13 :  24
Oklahoma Sooners

Aug 30, 2025 - NCAA

New Mexico Lobos
17 :  34
Michigan Wolverines

Dec 31, 2024 - NCAA Division I, FBS, Playoffs

Alabama Crimson Tide
13 :  19
Michigan Wolverines
L W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Oct 4, 2025 - NCAA

Wisconsin Badgers
10 :  24
Michigan Wolverines

Sep 13, 2025 - NCAA

Central Michigan Chippewas
3 :  63
Michigan Wolverines

Aug 30, 2025 - NCAA

New Mexico Lobos
17 :  34
Michigan Wolverines

Dec 31, 2024 - NCAA Division I, FBS, Playoffs

Alabama Crimson Tide
13 :  19
Michigan Wolverines

Sep 21, 2024 - NCAA

USC Trojans
24 :  27
Michigan Wolverines

Sep 14, 2024 - NCAA

Arkansas State Red Wolves
18 :  28
Michigan Wolverines
L L L W L W
Victories

1/2 (50%)

Draw

0/2 (0%)

Defeats

1/2 (50%)

Sep 20, 2025 - NCAA

Michigan Wolverines
30 :  27
Nebraska Cornhuskers

Sep 6, 2025 - NCAA

Michigan Wolverines
13 :  24
Oklahoma Sooners
USC Trojans
USC Trojans Latest matches
W W W W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 27, 2025 - NCAA

USC Trojans
32 :  34
Illinois Fighting Illini

Sep 20, 2025 - NCAA

Michigan State Spartans
31 :  45
USC Trojans

Sep 13, 2025 - NCAA

USC Trojans
33 :  17
Purdue Boilermakers

Sep 6, 2025 - NCAA

Georgia Southern Eagles
20 :  59
USC Trojans

Aug 30, 2025 - NCAA

Missouri State Bears
13 :  73
USC Trojans

Sep 21, 2024 - NCAA

USC Trojans
24 :  27
Michigan Wolverines
W L W W W W
Victories

5/5 (100%)

Draw

0/5 (0%)

Defeats

0/5 (0%)

Sep 20, 2025 - NCAA

Michigan State Spartans
31 :  45
USC Trojans

Sep 6, 2025 - NCAA

Georgia Southern Eagles
20 :  59
USC Trojans

Aug 30, 2025 - NCAA

Missouri State Bears
13 :  73
USC Trojans

Sep 7, 2024 - NCAA

Utah State Aggies
0 :  48
USC Trojans

Sep 1, 2024 - NCAA

LSU Tigers
20 :  27
USC Trojans
L L L W W L
Victories

1/3 (33%)

Draw

0/3 (0%)

Defeats

2/3 (67%)

Sep 27, 2025 - NCAA

USC Trojans
32 :  34
Illinois Fighting Illini

Sep 13, 2025 - NCAA

USC Trojans
33 :  17
Purdue Boilermakers

Sep 21, 2024 - NCAA

USC Trojans
24 :  27
Michigan Wolverines

Michigan Wolverines against USC Trojans : Head to Head (H2H)

Sep 21, 2024 - NCAA

USC Trojans
24 :  27
Michigan Wolverines

Michigan Wolverines - USC Trojans Key Points

  1. Michigan is 1-1 ATS vs the Big Ten
  2. Michigan is averaging 27.0 points per game vs the Big Ten
  3. USC is 0-3 ATS vs the Big Ten this season
  4. USC is averaging 36.7 points per game vs the Big Ten

Our Michigan Wolverines vs USC Trojans Prediction

USC is the small favorite in this matchup; however, they have not done well this season at putting teams away. In fact, the Trojans have yet to cover the spread in three games against the Big Ten. The most recent blunder for USC was an outright loss to Illinois, and even though they have had their bye week since, Michigan is not an opponent they can afford to slack off against.

The Wolverines have the better defense of these two teams by far, as they have not allowed more than 27 points in any game this season. Given this, our USC Trojans vs Michigan Wolverines prediction is: Michigan Wolverines +3.5 Alternate Spread.

Prediction:

 

Michigan Wolverines +3.5 Alternate Spread

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Michigan Wolverines vs USC Trojans Picks