Michigan State Spartans vs Indiana Hoosiers Prediction & Picks - NCAA

USA - NCAA

Michigan State Spartans
10/18/25 15:30
Indiana Hoosiers

Prediction:

 

Indiana 27.5

-110
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 by Travis Pulver in NCAA Picks

The No. 3 Indiana Hoosiers (6-0) will host the Michigan State Spartans (3-3) at Memorial Stadium in Bloomington, IN, at 3:30 p.m. EST Saturday. Fans can follow the action once the game gets underway via the Peacock app.

This could be a trap game if the Hoosiers are not careful. After taking down Oregon in Eugene last weekend, it would be natural for Indiana to feel like it can coast this week against a mediocre Spartans team. The Hoosier offense and defense rank inside the top ten in several statistical categories. Surely, they don’t need to bring their ‘A’ game to beat Michigan State, right? Then again, there isn’t much for the Spartans to hang their hats on. All three wins came during their soft non-conference schedule; they’ve lost by double digits in all three conference losses. Barring Indiana making a number of mistakes in this game, Michigan State’s best chance will be to develop a run game, control the clock, and keep Fernando Mendoza and the IU offense on the sideline.

But that will be easier said than done against an Indiana defense averaging 86 rushing yards per game allowed. It would also require the Spartans to play above and beyond how they’ve performed this season (131.2 rushing yards per game) against the toughest opponent they’ll face all season.

Michigan State Spartans vs Indiana Hoosiers Form

Table

Teams % P W D L
2
Indiana Hoosiers
Indiana Hoosiers
1 4 4 0 0
16
Michigan State Spartans
Michigan State Spartans
0 4 0 0 4

Michigan State Spartans and Indiana Hoosiers Latest Matches

Michigan State Spartans
Michigan State Spartans Latest matches
W W W L L L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 11, 2025 - NCAA

UCLA Bruins
38 :  13
Michigan State Spartans

Oct 4, 2025 - NCAA

Michigan State Spartans
27 :  38
Nebraska Cornhuskers

Sep 20, 2025 - NCAA

Michigan State Spartans
31 :  45
USC Trojans

Sep 13, 2025 - NCAA

Youngstown State Penguins
24 :  41
Michigan State Spartans

Sep 6, 2025 - NCAA

Boston College Eagles
40 :  42
Michigan State Spartans

Aug 29, 2025 - NCAA

Western Michigan Broncos
6 :  23
Michigan State Spartans
W L W W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 11, 2025 - NCAA

UCLA Bruins
38 :  13
Michigan State Spartans

Sep 13, 2025 - NCAA

Youngstown State Penguins
24 :  41
Michigan State Spartans

Sep 6, 2025 - NCAA

Boston College Eagles
40 :  42
Michigan State Spartans

Aug 29, 2025 - NCAA

Western Michigan Broncos
6 :  23
Michigan State Spartans

Nov 30, 2024 - NCAA

Rutgers Scarlet Knights
41 :  14
Michigan State Spartans

Nov 22, 2024 - NCAA

Purdue Boilermakers
17 :  24
Michigan State Spartans
L L L L L
Victories

0/5 (0%)

Draw

0/5 (0%)

Defeats

5/5 (100%)

Oct 4, 2025 - NCAA

Michigan State Spartans
27 :  38
Nebraska Cornhuskers

Sep 20, 2025 - NCAA

Michigan State Spartans
31 :  45
USC Trojans

Nov 16, 2024 - NCAA

Michigan State Spartans
16 :  38
Illinois Fighting Illini

Oct 26, 2024 - NCAA

Michigan State Spartans
17 :  24
Michigan Wolverines

Oct 4, 2024 - NCAA

Michigan State Spartans
10 :  31
Oregon Ducks
Indiana Hoosiers
Indiana Hoosiers Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Oct 11, 2025 - NCAA

Indiana Hoosiers
30 :  20
Oregon Ducks

Sep 27, 2025 - NCAA

Indiana Hoosiers
20 :  15
Iowa Hawkeyes

Sep 20, 2025 - NCAA

Illinois Fighting Illini
10 :  63
Indiana Hoosiers

Sep 12, 2025 - NCAA

Indiana State Sycamores
0 :  73
Indiana Hoosiers

Sep 6, 2025 - NCAA

Kennesaw State Owls
9 :  56
Indiana Hoosiers

Aug 30, 2025 - NCAA

Old Dominion Monarchs
14 :  27
Indiana Hoosiers
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Sep 20, 2025 - NCAA

Illinois Fighting Illini
10 :  63
Indiana Hoosiers

Sep 12, 2025 - NCAA

Indiana State Sycamores
0 :  73
Indiana Hoosiers

Sep 6, 2025 - NCAA

Kennesaw State Owls
9 :  56
Indiana Hoosiers

Aug 30, 2025 - NCAA

Old Dominion Monarchs
14 :  27
Indiana Hoosiers

Nov 30, 2024 - NCAA

Purdue Boilermakers
0 :  66
Indiana Hoosiers

Nov 9, 2024 - NCAA

Michigan Wolverines
15 :  20
Indiana Hoosiers
W L L W W
Victories

3/5 (60%)

Draw

0/5 (0%)

Defeats

2/5 (40%)

Oct 11, 2025 - NCAA

Indiana Hoosiers
30 :  20
Oregon Ducks

Sep 27, 2025 - NCAA

Indiana Hoosiers
20 :  15
Iowa Hawkeyes

Dec 20, 2024 - NCAA

Indiana Hoosiers
17 :  27
Notre Dame Fighting Irish

Nov 23, 2024 - NCAA

Indiana Hoosiers
15 :  38
Ohio State Buckeyes

Nov 2, 2024 - NCAA

Indiana Hoosiers
47 :  10
Michigan State Spartans

Michigan State Spartans against Indiana Hoosiers : Head to Head (H2H)

Nov 2, 2024 - NCAA

Indiana Hoosiers
47 :  10
Michigan State Spartans

Michigan State Spartans - Indiana Hoosiers Key Points

  1. Michigan State leads the all-time series vs. Indiana 50-19-2.
  2. Indiana blew out the Spartans in East Lansing last season, 47-10, but hasn't won back-to-back games vs. Michigan State since winning three in a row from 1967-69.
  3. Michigan State is 2-1 ATS in conference play; Indiana is 2-1 ATS in games where they were 20+-point favorites.
  4. Betting Public: 38% of spread tickets and 59% of the handle are on Michigan State.

Our Michigan State Spartans vs Indiana Hoosiers Prediction

As long as the Hoosiers don’t phone it in, Indiana will win this game (and there is no reason to believe that they will). So, the question is whether they can cover a 27.5-point spread. IU certainly has the firepower, whether they’re running the ball or via the pass game, to run up the score on the Spartans. Michigan State has talent, but not enough to slow the Hoosiers down. With how the Indiana defense has played, the Spartans may not get a first down until garbage time. It’s a giant spread,  but I think the Hoosiers will cover it against this Spartans team.

Our Michigan State vs. Indiana Pick: Indiana -27.5

Prediction:

 

Indiana 27.5

-110
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Michigan State Spartans vs Indiana Hoosiers Picks