LSU Tigers vs Vanderbilt Commodores Prediction & Picks - NCAA

USA - NCAA

LSU Tigers
10/18/25 12:00
Vanderbilt Commodores

Prediction:

 

LSU Tigers +3.5 Alternate Spread

-140
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 by Matt Lowrimore | in NCAA Picks

One of the many games on Saturday’s Week 8 college football slate will see the 10th-ranked LSU Tigers take on the 17th-ranked Vanderbilt Commodores in the SEC. Let’s take a look at the match statistics and predictions for this game between the Tigers and the Commodores.

LSU enters this game with a record of 5-1 and 2-1 in the SEC. The Tigers most recently beat the South Carolina Gamecocks in Week 7 by a score of 20-10. LSU’s offense had a total of 422 yards, while its defense allowed 317 yards. Quarterback Garrett Nussmeier threw for 254 yards, two touchdowns, and two interceptions, while running back Caden Durham led the team in rushing with 70 yards.

As for Vanderbilt, they enter this game with a record of 5-1 and 1-1 in the SEC. The Commodores most recently lost to the Alabama Crimson Tide in Week 6 by a score of 30-14. Vanderbilt’s offense had a total of 333 yards, while its defense allowed 486 yards. Quarterback Diego Pavia threw for 198 yards, one touchdown, and one interception, while running back Sedrick Alexander led the team in rushing with 76 yards and one touchdown.

LSU Tigers vs Vanderbilt Commodores Form

Table

Teams % P W D L
7
Vanderbilt Commodores
Vanderbilt Commodores
0.75 8 6 0 2
10
LSU Tigers
LSU Tigers
0.375 8 3 0 5

LSU Tigers and Vanderbilt Commodores Latest Matches

LSU Tigers
LSU Tigers Latest matches
W W W W L W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 11, 2025 - NCAA

South Carolina Gamecocks
10 :  20
LSU Tigers

Sep 27, 2025 - NCAA

LSU Tigers
19 :  24
Ole Miss Rebels

Sep 20, 2025 - NCAA

Southeastern Louisiana Lions
10 :  56
LSU Tigers

Sep 13, 2025 - NCAA

Florida Gators
10 :  20
LSU Tigers

Sep 6, 2025 - NCAA

Louisiana Tech Bulldogs
7 :  23
LSU Tigers

Aug 30, 2025 - NCAA

LSU Tigers
17 :  10
Clemson Tigers
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Oct 11, 2025 - NCAA

South Carolina Gamecocks
10 :  20
LSU Tigers

Sep 20, 2025 - NCAA

Southeastern Louisiana Lions
10 :  56
LSU Tigers

Sep 13, 2025 - NCAA

Florida Gators
10 :  20
LSU Tigers

Sep 6, 2025 - NCAA

Louisiana Tech Bulldogs
7 :  23
LSU Tigers

Dec 31, 2024 - NCAA Division I, FBS, Playoffs

Baylor Bears
31 :  44
LSU Tigers

Sep 21, 2024 - NCAA

UCLA Bruins
17 :  34
LSU Tigers
W W L L W L
Victories

2/4 (50%)

Draw

0/4 (0%)

Defeats

2/4 (50%)

Sep 27, 2025 - NCAA

LSU Tigers
19 :  24
Ole Miss Rebels

Aug 30, 2025 - NCAA

LSU Tigers
17 :  10
Clemson Tigers

Sep 14, 2024 - NCAA

LSU Tigers
36 :  33
South Carolina Gamecocks

Sep 1, 2024 - NCAA

LSU Tigers
20 :  27
USC Trojans
Vanderbilt Commodores
Vanderbilt Commodores Latest matches
W W W W W L
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 4, 2025 - NCAA

Vanderbilt Commodores
14 :  30
Alabama Crimson Tide

Sep 27, 2025 - NCAA

Utah State Aggies
35 :  55
Vanderbilt Commodores

Sep 20, 2025 - NCAA

Georgia State Panthers
21 :  70
Vanderbilt Commodores

Sep 13, 2025 - NCAA

Vanderbilt Commodores
31 :  7
South Carolina Gamecocks

Sep 6, 2025 - NCAA

Vanderbilt Commodores
44 :  20
Virginia Tech Hokies

Aug 30, 2025 - NCAA

Charleston Southern Buccaneers
3 :  45
Vanderbilt Commodores
L L W W W W
Victories

5/5 (100%)

Draw

0/5 (0%)

Defeats

0/5 (0%)

Sep 27, 2025 - NCAA

Utah State Aggies
35 :  55
Vanderbilt Commodores

Sep 20, 2025 - NCAA

Georgia State Panthers
21 :  70
Vanderbilt Commodores

Aug 30, 2025 - NCAA

Charleston Southern Buccaneers
3 :  45
Vanderbilt Commodores

Dec 27, 2024 - NCAA Division I, FBS, Playoffs

Georgia Tech Yellow Jackets
27 :  35
Vanderbilt Commodores

Oct 19, 2024 - NCAA

Ball State Cardinals
14 :  24
Vanderbilt Commodores
W W L W W L
Victories

2/4 (50%)

Draw

0/4 (0%)

Defeats

2/4 (50%)

Oct 4, 2025 - NCAA

Vanderbilt Commodores
14 :  30
Alabama Crimson Tide

Sep 13, 2025 - NCAA

Vanderbilt Commodores
31 :  7
South Carolina Gamecocks

Sep 6, 2025 - NCAA

Vanderbilt Commodores
44 :  20
Virginia Tech Hokies

Sep 21, 2024 - NCAA

Vanderbilt Commodores
27 :  30
Missouri Tigers

LSU Tigers - Vanderbilt Commodores Key Points

  1. Vanderbilt is 1-1 ATS vs the SEC
  2. Vanderbilt is averaging 22.5 points per game vs the SEC
  3. LSU is 2-1 ATS vs the SEC
  4. LSU is averaging 19.6 points per game vs the SEC

Our LSU Tigers vs Vanderbilt Commodores Prediction

As good as Vanderbilt has been this season, this will be another tough test. The good news is that the game will be played at Vanderbilt; however, there is still reason to believe that the Tigers will be able to walk out of Nashville with a win. 

LSU has not put a ton of points on the board in games against the SEC, but their defense has been more than up to the task, as they have allowed an average of 14.6 points per game in three SEC games. 

Vanderbilt quarterback, Diego Pavia, is likely going to be the X-factor in this matchup, but given how well LSU has been playing, our LSU Tigers vs Vanderbilt Commodores prediction is: LSU Tigers +3.5 Alternate Spread.

Prediction:

 

LSU Tigers +3.5 Alternate Spread

-140
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LSU Tigers vs Vanderbilt Commodores Picks