LSU Tigers vs Ole Miss Rebels Prediction & Picks - NCAA

USA - NCAA

LSU Tigers
9/27/25 15:30
Ole Miss Rebels

Prediction:

 

Ole Miss Rebels ML

-120
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 by Matt Lowrimore in NCAA Picks

One of the best games on the Saturday Week 5 college football slate will see the 4th-ranked LSU Tigers take on the 13th-ranked Ole Miss Rebels in an SEC matchup. Let’s take a look at the match statistics and predictions for this game between the Tigers and the Rebels.

LSU enters this game with a record 4-0 and 1-0 in the SEC. The Tigers most recently beat the SE Louisiana Lions in Week 4 by a score of 56-10. LSU’s offense had a total of 530 yards, while its defense allowed 205 yards. Quarterback Garrett Nussmeier threw for 273 yards and three touchdowns, while running back Ju’Juan Johnson led the team in rushing with 43 yards and two touchdowns. 

As for Ole Miss, they enter this game with a record of 4-0 and 2-0 in the SEC. The Rebels most recently beat the Tulane Green Wave in Week 4 by a score of 45-10. Ole Miss’ offense had a total of 548 yards, while its defense allowed 282 yards. Quarterback Trinidad Chambliss threw for 307 yards and two touchdowns, while also leading the team in rushing with 112 yards.

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LSU Tigers vs Ole Miss Rebels Form

Table

Teams % P W D L
1
Ole Miss Rebels
Ole Miss Rebels
1 2 2 0 0
4
LSU Tigers
LSU Tigers
1 1 1 0 0

LSU Tigers and Ole Miss Rebels Latest Matches

LSU Tigers
LSU Tigers Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Sep 20, 2025 - NCAA

Southeastern Louisiana Lions
10 :  56
LSU Tigers

Sep 13, 2025 - NCAA

Florida Gators
10 :  20
LSU Tigers

Sep 6, 2025 - NCAA

Louisiana Tech Bulldogs
7 :  23
LSU Tigers

Aug 30, 2025 - NCAA

LSU Tigers
17 :  10
Clemson Tigers

Dec 31, 2024 - NCAA Division I, FBS, Playoffs

Baylor Bears
31 :  44
LSU Tigers

Nov 30, 2024 - NCAA

Oklahoma Sooners
17 :  37
LSU Tigers
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Sep 20, 2025 - NCAA

Southeastern Louisiana Lions
10 :  56
LSU Tigers

Sep 13, 2025 - NCAA

Florida Gators
10 :  20
LSU Tigers

Sep 6, 2025 - NCAA

Louisiana Tech Bulldogs
7 :  23
LSU Tigers

Dec 31, 2024 - NCAA Division I, FBS, Playoffs

Baylor Bears
31 :  44
LSU Tigers

Nov 30, 2024 - NCAA

Oklahoma Sooners
17 :  37
LSU Tigers

Nov 23, 2024 - NCAA

Vanderbilt Commodores
17 :  24
LSU Tigers
L W W L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Aug 30, 2025 - NCAA

LSU Tigers
17 :  10
Clemson Tigers

Nov 16, 2024 - NCAA

LSU Tigers
16 :  27
Florida Gators

Oct 26, 2024 - NCAA

LSU Tigers
23 :  38
Texas A&M Aggies

Oct 19, 2024 - NCAA

LSU Tigers
34 :  10
Arkansas Razorbacks

Sep 14, 2024 - NCAA

LSU Tigers
36 :  33
South Carolina Gamecocks

Sep 1, 2024 - NCAA

LSU Tigers
20 :  27
USC Trojans
Ole Miss Rebels
Ole Miss Rebels Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Sep 20, 2025 - NCAA

Tulane Green Wave
10 :  45
Ole Miss Rebels

Sep 13, 2025 - NCAA

Arkansas Razorbacks
35 :  41
Ole Miss Rebels

Sep 6, 2025 - NCAA

Ole Miss Rebels
30 :  23
Kentucky Wildcats

Aug 30, 2025 - NCAA

Georgia State Panthers
7 :  63
Ole Miss Rebels

Jan 2, 2025 - NCAA Division I, FBS, Playoffs

Duke Blue Devils
20 :  52
Ole Miss Rebels

Nov 29, 2024 - NCAA

Mississippi State Bulldogs
14 :  26
Ole Miss Rebels
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Sep 20, 2025 - NCAA

Tulane Green Wave
10 :  45
Ole Miss Rebels

Sep 13, 2025 - NCAA

Arkansas Razorbacks
35 :  41
Ole Miss Rebels

Aug 30, 2025 - NCAA

Georgia State Panthers
7 :  63
Ole Miss Rebels

Jan 2, 2025 - NCAA Division I, FBS, Playoffs

Duke Blue Devils
20 :  52
Ole Miss Rebels

Nov 29, 2024 - NCAA

Mississippi State Bulldogs
14 :  26
Ole Miss Rebels

Nov 9, 2024 - NCAA

Georgia Bulldogs
10 :  28
Ole Miss Rebels
W L W L W
Victories

3/5 (60%)

Draw

0/5 (0%)

Defeats

2/5 (40%)

Sep 6, 2025 - NCAA

Ole Miss Rebels
30 :  23
Kentucky Wildcats

Nov 23, 2024 - NCAA

Ole Miss Rebels
17 :  24
Florida Gators

Nov 2, 2024 - NCAA

Ole Miss Rebels
63 :  31
Arkansas Razorbacks

Oct 12, 2024 - NCAA

Ole Miss Rebels
26 :  29
LSU Tigers

Oct 5, 2024 - NCAA

Ole Miss Rebels
27 :  3
South Carolina Gamecocks

LSU Tigers against Ole Miss Rebels : Head to Head (H2H)

Oct 12, 2024 - NCAA

Ole Miss Rebels
26 :  29
LSU Tigers

LSU Tigers - Ole Miss Rebels Key Points

  1. LSU is 2-2 ATS this season
  2. LSU is averaging 35.0 points per game this season
  3. Ole Miss is 3-1 ATS this season
  4. Ole Miss is averaging 44.8 points per game this season
Up to $400+ to bet on LSU Tigers - Ole Miss Rebels! 

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Our LSU Tigers vs Ole Miss Rebels Prediction

LSU has some good wins this season, but this will likely be their biggest test as they head into Oxford to take on the Rebels. The one criticism about LSU is that they have not put their opponents away, not counting the game against an inferior SE Louisiana team. The Tigers won by just seven against Clemson, 16 against Louisiana Tech, and 10 against Florida.

In the same sense, Ole Miss has had some close games too, but the Rebels look to be more balanced offensively. Further, Ole Miss has two quarterbacks who can beat you in multiple ways, which is why they are averaging more than 40 points per game. Regardless of whether Austin Simmons or Trinidad Chambliss starts at quarterback, the home crowd could be the difference for Ole Miss. That and the balance they employ on offense means our LSU Tigers vs Ole Miss Rebels prediction is: Ole Miss Rebels ML.

Prediction:

 

Ole Miss Rebels ML

-120
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LSU Tigers vs Ole Miss Rebels Picks
Up to $400+ to bet on LSU Tigers - Ole Miss Rebels! 

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