Los Angeles FC vs Inter Miami Prediction & Picks - Major League Soccer

USA - Major League Soccer

Los Angeles FC
2/21/26 21:30
Inter Miami

Prediction:

 

Lionel Messi 1+ Assists

+240
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 by Bradley Gibbs | in Major League Soccer Picks

What is arguably the most high-profile game during the opening weekend of the 2026 Major League Soccer campaign will take place at BMO Stadium on Saturday evening, where LAFC and Inter Miami will clash. This is a battle between two of the last four MLS Cup winners, with LAFC picking up the top prize back in 2022, while the Herons went all the way in 2025. 

Both teams were very strong during the previous regular campaign, with LAFC finishing third in the Western Conference. Inter Miami finished third in the Eastern Conference, so this is absolutely a game between two of the biggest hitters in all of Major League Soccer. There was no cross-conference action between these two last season, but they did meet in the CONCACAF Champions Cup. Saturday's hosts won by a goal to zero at this venue, before losing 3-1 in Miami. Another interesting game awaits. 

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Los Angeles FC vs Inter Miami Form

Table

Teams Pts P W D L GD
4 Inter Miami
31 15 9 4 2 +11
9 Los Angeles FC
24 15 7 3 5 +7

Los Angeles FC and Inter Miami Latest Matches

Los Angeles FC
Los Angeles FC Latest matches
L D W W D W
Victories

3/6 (50%)

Draw

2/6 (33%)

Defeats

1/6 (17%)

Average stats (Last 6 matchs)

4 Total goals
83% BTTS
2.67 Goals scored
1.33 Goals conceded
83% Over 2.5
17% Under 2.5

Feb 17, 2026 - Concachampions

Real CD Espana San Pedro Sula
1 :  6
Los Angeles FC

Nov 22, 2025 - Major League Soccer

Vancouver Whitecaps
2 :  2
Los Angeles FC

Nov 2, 2025 - Major League Soccer

Austin FC
1 :  4
Los Angeles FC

Oct 29, 2025 - Major League Soccer

Los Angeles FC
2 :  1
Austin FC

Oct 18, 2025 - Major League Soccer

Colorado Rapids
2 :  2
Los Angeles FC

Oct 12, 2025 - Major League Soccer

Austin FC
1 :  0
Los Angeles FC
D L W W W W
Victories

4/6 (67%)

Draw

1/6 (17%)

Defeats

1/6 (17%)

Average stats (Last 6 matchs)

2.67 Total goals
67% BTTS
1.83 Goals scored
0.83 Goals conceded
50% Over 2.5
50% Under 2.5

Oct 29, 2025 - Major League Soccer

Los Angeles FC
2 :  1
Austin FC

Oct 8, 2025 - Major League Soccer

Los Angeles FC
2 :  0
Toronto FC

Oct 5, 2025 - Major League Soccer

Los Angeles FC
1 :  0
Atlanta United Fc

Sep 21, 2025 - Major League Soccer

Los Angeles FC
4 :  1
Real Salt Lake

Aug 31, 2025 - Major League Soccer

Los Angeles FC
1 :  2
San Diego FC

Aug 1, 2025 - Leagues Cup

Los Angeles FC
1 :  1
CF Pachuca
W L D W D W
Victories

3/6 (50%)

Draw

2/6 (33%)

Defeats

1/6 (17%)

Average stats (Last 6 matchs)

4 Total goals
67% BTTS
2.83 Goals scored
1.17 Goals conceded
83% Over 2.5
17% Under 2.5

Feb 17, 2026 - Concachampions

Real CD Espana San Pedro Sula
1 :  6
Los Angeles FC

Nov 22, 2025 - Major League Soccer

Vancouver Whitecaps
2 :  2
Los Angeles FC

Nov 2, 2025 - Major League Soccer

Austin FC
1 :  4
Los Angeles FC

Oct 18, 2025 - Major League Soccer

Colorado Rapids
2 :  2
Los Angeles FC

Oct 12, 2025 - Major League Soccer

Austin FC
1 :  0
Los Angeles FC

Sep 27, 2025 - Major League Soccer

Saint Louis City SC
0 :  3
Los Angeles FC
Inter Miami
Inter Miami Latest matches
W L W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Average stats (Last 6 matchs)

4.17 Total goals
67% BTTS
3.33 Goals scored
0.83 Goals conceded
100% Over 2.5
0% Under 2.5

Dec 6, 2025 - Major League Soccer

Inter Miami
3 :  1
Vancouver Whitecaps

Nov 29, 2025 - Major League Soccer

Inter Miami
5 :  1
New York City

Nov 23, 2025 - Major League Soccer

FC Cincinnati
0 :  4
Inter Miami

Nov 8, 2025 - Major League Soccer

Inter Miami
4 :  0
Nashville SC

Nov 1, 2025 - Major League Soccer

Nashville SC
2 :  1
Inter Miami

Oct 24, 2025 - Major League Soccer

Inter Miami
3 :  1
Nashville SC
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Average stats (Last 6 matchs)

4.5 Total goals
67% BTTS
3.83 Goals scored
0.67 Goals conceded
100% Over 2.5
0% Under 2.5

Dec 6, 2025 - Major League Soccer

Inter Miami
3 :  1
Vancouver Whitecaps

Nov 29, 2025 - Major League Soccer

Inter Miami
5 :  1
New York City

Nov 8, 2025 - Major League Soccer

Inter Miami
4 :  0
Nashville SC

Oct 24, 2025 - Major League Soccer

Inter Miami
3 :  1
Nashville SC

Oct 11, 2025 - Major League Soccer

Inter Miami
4 :  0
Atlanta United Fc

Oct 4, 2025 - Major League Soccer

Inter Miami
4 :  1
New England Revolution
L W D W L W
Victories

3/6 (50%)

Draw

1/6 (17%)

Defeats

2/6 (33%)

Average stats (Last 6 matchs)

3.83 Total goals
50% BTTS
2.5 Goals scored
1.33 Goals conceded
83% Over 2.5
17% Under 2.5

Nov 23, 2025 - Major League Soccer

FC Cincinnati
0 :  4
Inter Miami

Nov 1, 2025 - Major League Soccer

Nashville SC
2 :  1
Inter Miami

Oct 18, 2025 - Major League Soccer

Nashville SC
2 :  5
Inter Miami

Sep 27, 2025 - Major League Soccer

Toronto FC
1 :  1
Inter Miami

Sep 24, 2025 - Major League Soccer

New York City
0 :  4
Inter Miami

Sep 13, 2025 - Major League Soccer

Charlotte FC
3 :  0
Inter Miami

Los Angeles FC against Inter Miami : Head to Head (H2H)

Los Angeles FC

60 %

Draw

0 %

Inter Miami

40 %

Average stats (last H2H results)

2.4
Total goals
40%
BTTS
1.2
Goals scored
1.2
Goals conceded
40%
Over 2.5
60%
Under 2.5

Apr 9, 2025 - Concachampions

Inter Miami
3 :  1
Los Angeles FC

Apr 2, 2025 - Concachampions

Los Angeles FC
1 :  0
Inter Miami

Sep 3, 2023 - Major League Soccer

Los Angeles FC
1 :  3
Inter Miami

Mar 12, 2022 - Major League Soccer

Inter Miami
0 :  2
Los Angeles FC

Mar 1, 2020 - Major League Soccer

Los Angeles FC
1 :  0
Inter Miami

Los Angeles FC - Inter Miami: Form Analysis

Pre-season hasn't gone too badly for the LAFC boys, who've not lost any of their three friendlies ahead of this fixture. They did tie two of those warm-up games, failing to keep a clean sheet in both, which doesn't exactly bode well ahead of a game against one of strongest offensive set-ups that Major League Soccer has to offer. Last time out, the LAFC boys got back down to business competitively, playing in the CONCACAF Champions Cup, and they certainly sharpened their offensive tools, scoring six goals. 

This will be Inter Miami's first competitive match since beating the Vancouver Whitecaps in MLS Cup Final back in early December.

This will be Inter Miami's first competitive match since beating the Vancouver Whitecaps in MLS Cup Final back in early December. They've since won one, lost one and tied one in friendlies, most recently tying 2-2 with Ecuadorian outfit Barcelona SC. They'll now be looking to step on the gas and make a winning start to the 2026 MLS season. 

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Los Angeles FC against Inter Miami Lineups: Starting 11

Los Angeles FC

Formation : 4 - 3 - 3

1
H. Lloris
14
S. Palencia
91
N. Tafari
5
R. Porteous
4
E. Segura
11
T. Tillman
46
S. Eustaquio
8
M. Delgado
30
D. Martinez
7
S. Heung-min
99
D. Bouanga
19
G. Berterame
8
T. Segovia
10
L. Messi
24
M. Silvetti
42
Y. Bright
7
R. De Paul
32
N. Allen
16
Micael
37
M. Falcon
17
I. Fray
97
D. St. Clair

Formation : 4 - 2 - 3 - 1

Inter Miami

Substitutes

Los Angeles FC
Los Angeles FC
Goalkeeper

T. Hasal

Defender

A. Smoliakov

K. Nielsen

R. Hollingshead

Midfielder

R. Raposo

M. Choiniere

D. Martinez 68'

Forward

N. Ordaz

S. Heung-min 88'

A. Boudri

T. Boyd

T. Tillman 82'

Inter Miami
Inter Miami
Goalkeeper

R. Rios Novo

Defender

F. Mura

I. Fray 46'

G. Lujan

Midfielder

D. Ayala

D. Ruiz

S. Morales

Forward

D. Pinter

T. Allende

Y. Bright 68'

L. Suarez

M. Silvetti 81'

Missing players

Los Angeles FC
Los Angeles FC
Defender

A. Long

Midfielder

J. Shaffelburg

I. Jesus

Forward

J. Ebobisse

Inter Miami
Inter Miami

Los Angeles FC & Inter Miami Squad Analysis

The hosts are expected to be without the services of Jeremy Ebobisse, who probably wouldn't have started this fixture even if he was fit, though the absence of the US forward gives head coach Marc Dos Santos less options from the bench. Heung-min Son who was in electric form having come in half way through the previous campaign will start in offense, as will Denis Bouanga. Those two players formed a deadly partnership towards the end of 2025. 

Lionel Messi is expected to anchor a more junior offense that contains Mateo Silvetti. 

For Inter Miami, there will be no Sergi Reguilon, who is out injured, while Ryan Sailor will also miss out with injury. Veteran Luis Suarez is expected to start on the bench, with Uruguay's all-time top scorer to be used more sparingly this term.  Lionel Messi is expected to anchor a more junior offense that contains Mateo Silvetti. 

Most goals and assists

CD Huachipato Los Angeles FC
CD Huachipato Inter Miami
Top Goalscorer
Gabon D. Bouanga (6 Goals)
Top Goalscorer
Argentina L. Messi (12 Goals)
Best assists
South Korea S. Heung-min (8 Assists)
Best assists
Argentina L. Messi (7 Assists)

Los Angeles FC - Inter Miami Key Points

  1. Only one MLS player registered more assists than Lionel Messi in 2025.
  2. During the 2025 campaign, Lionel Messi produced an impressive 16 assists.
  3. Per 90 minutes last season, Lionel Messi registered an average of 0.59 assists.
  4. Lionel Messi signed off the 2025 campaign by registering seven MLS assists in his last four appearances.
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Our Los Angeles FC vs Inter Miami Prediction

Clearly one of Major League Soccer's most creative players, Lionel Messi is absolutely expected to pull the strings for Inter Miami again this season, and the man considered by many to be the greatest soccer player of all time can begin the 2026 campaign by causing lots of problems for LAFC. 

Only Anders Dreyer of San Diego registered more MLS assists than Messi last season, while nobody ended the campaign in anywhere near as hot form creatively. If Messi is half as creative here as he was during MLS Cup Final, odds of +240 will start to look very generous indeed. 

Our LAFC vs Inter Miami Pick: Lionel Messi 1+ Assists. 

Prediction:

 

Lionel Messi 1+ Assists

+240
$200 offered for betting!

Los Angeles FC vs Inter Miami - Other Interesting Picks

Lionel Messi 2+ Shots on Target

Odds -140
Additionally, I'll be betting on Lionel Messi to register a couple of shots on target, which is something he did when these two last met. Messi made light work of regularly firing off shots in 2025, not only scoring 29 goals but also registering 71 shots on target. In his final seven MLS games last season, Messi registered 13 shots on target.
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Los Angeles FC vs Inter Miami match : Frequently asked questions

This game will be played at BMO Stadium in Los Angeles.

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Los Angeles FC vs Inter Miami Picks