San Francisco Giants vs Los Angeles Dodgers Prediction & Picks - MLB

USA - MLB

San Francisco Giants
4/22/26 21:45
Los Angeles Dodgers

Prediction:

 

The Dodgers -1.5 Runs

-125
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 by Lou Aguila | in MLB Picks

The Los Angeles Dodgers are 2-1 in Shohei Ohtani’s first three starts this season. Ohtani, who is listed at +190 on the pitcher’s props of 8+ strikeouts, is scheduled to start in Game 2 of the series against the San Francisco Giants.

Momentum: The Los Angeles Dodgers have dropped 3 of their last 4 assignments, sliding to 16-7 in the season. The San Francisco Giants have won four of their last five to hike their record to 10-13 after a 3-8 start in the season.

The Matchup: The Giants drew first blood in the first of many series with the Dodgers this season, banking on another strong outing from starting pitcher Landen Roupp, who surrendered one earned run over five innings, in a 3-1 win over their NL West rivals.

Starting Pitchers: Dodgers RHP Shohei Ohtani (2-0, 0.50 ERA) vs. Giants RHP Tyler Mahle (0-3, 7.23 ERA).

Hot on the Board: The Dodgers, who are 2-1 in Ohtani’s 3 starts this season, are -220 moneyline and -125 to cover -1.5 runs at Caesars Sportsbooks. Meanwhile, Ohtani fetches a value of +165 on DraftKings if he can register at least 8 strikeouts in this game.

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San Francisco Giants vs Los Angeles Dodgers Form

Table

Teams Pts P W L
1 Los Angeles Dodgers
0.639 83 53 30
28 San Francisco Giants
0.415 82 34 48

San Francisco Giants and Los Angeles Dodgers Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 21, 2026 - MLB

San Francisco Giants
3 :  1
Los Angeles Dodgers

Apr 19, 2026 - MLB

Washington Nationals
3 :  0
San Francisco Giants

Apr 18, 2026 - MLB

Washington Nationals
6 :  7
San Francisco Giants

Apr 17, 2026 - MLB

Washington Nationals
5 :  10
San Francisco Giants

Apr 16, 2026 - MLB

Cincinnati Reds
0 :  3
San Francisco Giants

Apr 15, 2026 - MLB

Cincinnati Reds
8 :  3
San Francisco Giants
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 21, 2026 - MLB

San Francisco Giants
3 :  1
Los Angeles Dodgers

Apr 8, 2026 - MLB

San Francisco Giants
5 :  0
Philadelphia Phillies

Apr 7, 2026 - MLB

San Francisco Giants
6 :  0
Philadelphia Phillies

Apr 6, 2026 - MLB

San Francisco Giants
4 :  6
Philadelphia Phillies

Apr 5, 2026 - MLB

San Francisco Giants
2 :  5
New York Mets

Apr 4, 2026 - MLB

San Francisco Giants
0 :  9
New York Mets
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 19, 2026 - MLB

Washington Nationals
3 :  0
San Francisco Giants

Apr 18, 2026 - MLB

Washington Nationals
6 :  7
San Francisco Giants

Apr 17, 2026 - MLB

Washington Nationals
5 :  10
San Francisco Giants

Apr 16, 2026 - MLB

Cincinnati Reds
0 :  3
San Francisco Giants

Apr 15, 2026 - MLB

Cincinnati Reds
8 :  3
San Francisco Giants

Apr 14, 2026 - MLB

Cincinnati Reds
2 :  1
San Francisco Giants
Los Angeles Dodgers
Los Angeles Dodgers Latest matches
W W L L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 21, 2026 - MLB

San Francisco Giants
3 :  1
Los Angeles Dodgers

Apr 20, 2026 - MLB

Colorado Rockies
3 :  12
Los Angeles Dodgers

Apr 19, 2026 - MLB

Colorado Rockies
9 :  6
Los Angeles Dodgers

Apr 18, 2026 - MLB

Colorado Rockies
4 :  3
Los Angeles Dodgers

Apr 17, 2026 - MLB

Colorado Rockies
1 :  7
Los Angeles Dodgers

Apr 15, 2026 - MLB

Los Angeles Dodgers
8 :  2
New York Mets
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 15, 2026 - MLB

Los Angeles Dodgers
8 :  2
New York Mets

Apr 14, 2026 - MLB

Los Angeles Dodgers
2 :  1
New York Mets

Apr 13, 2026 - MLB

Los Angeles Dodgers
4 :  0
New York Mets

Apr 12, 2026 - MLB

Los Angeles Dodgers
2 :  5
Texas Rangers

Apr 11, 2026 - MLB

Los Angeles Dodgers
6 :  3
Texas Rangers

Apr 10, 2026 - MLB

Los Angeles Dodgers
8 :  7
Texas Rangers
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 21, 2026 - MLB

San Francisco Giants
3 :  1
Los Angeles Dodgers

Apr 20, 2026 - MLB

Colorado Rockies
3 :  12
Los Angeles Dodgers

Apr 19, 2026 - MLB

Colorado Rockies
9 :  6
Los Angeles Dodgers

Apr 18, 2026 - MLB

Colorado Rockies
4 :  3
Los Angeles Dodgers

Apr 17, 2026 - MLB

Colorado Rockies
1 :  7
Los Angeles Dodgers

Apr 8, 2026 - MLB

Toronto Blue Jays
4 :  3
Los Angeles Dodgers

San Francisco Giants against Los Angeles Dodgers : Head to Head (H2H)

San Francisco Giants

50 %

Los Angeles Dodgers

50 %

Apr 21, 2026 - MLB

San Francisco Giants
3 :  1
Los Angeles Dodgers

Mar 18, 2026 - MLB Spring Training

Los Angeles Dodgers
5 :  1
San Francisco Giants

Feb 27, 2026 - MLB Spring Training

San Francisco Giants
12 :  4
Los Angeles Dodgers

Sep 21, 2025 - MLB

Los Angeles Dodgers
1 :  3
San Francisco Giants

Sep 20, 2025 - MLB

Los Angeles Dodgers
7 :  5
San Francisco Giants

Sep 19, 2025 - MLB

Los Angeles Dodgers
6 :  3
San Francisco Giants

San Francisco Giants - Los Angeles Dodgers Key Points

  1. LA Dodgers is 5-2 SU in its last 7 games against San Francisco.
  2. LA Dodgers is 15-5 SU in its last 20 games on the road.
  3. San Francisco is 4-1 SU in its last 5 games.
  4. Shohei Ohtani is 2-1 in his last three starts vs. the San Francisco Giants
Up to $250 to bet on San Francisco Giants - Los Angeles Dodgers! 

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Our San Francisco Giants vs Los Angeles Dodgers Prediction

Fearless Forecast: The Dodgers level the series with a 5-1 win over the San Francisco Giants

With Shohei Ohtani starting, the Dodgers have an opportunity to assert their dominance over their Bay Area rivals. Los Angeles is 7-3 in its last 10 meetings with San Francisco. The last time Ohtani hit the mound, the Dodgers obliterated the New York Mets 8-2. Averaging 6.1 runs per game this season, the Dodgers are expected to put up more runs on the board in Game 2 after they were held down to one run in the series opener. Watch out for the Dodgers to apply pressure on the Giants starter, Tyler Mahle, who gave up eight runs over four innings in his last start vs. Cincinnati on April 15.

Our betting prediction for the Los Angeles Dodgers vs. the San Francisco Giants: The Dodgers -1.5 Runs

Prediction:

 

The Dodgers -1.5 Runs

-125
$250 offered for betting!

San Francisco Giants vs Los Angeles Dodgers - Other Interesting Picks

Shohei Ohtani +8 Strikeouts

Odds +190

Bonus Tip: Shohei Ohtani struck out 10 batters in the Dodgers’ 8-2 win over the Mets on April 15. Against the Giants, Ohtani carries a 2-1 record with a 0.3 earned runs across 15 innings pitched. The four-time MVP has a total of 18 strikeouts against the Giants, and once recorded 9 strikeouts against San Francisco almost five years ago.

Right now, Ohtani is trading at +194 on the contingent that he can rack up at least 8 strikeouts in Game 2. Based on his form in his last start, I am confident that the Dodgers’ ace is due to provide us with another virtuoso performance on the mound, giving his 10-strikeout performance against the Mets a fitting follow-up.

Our betting prediction for the Los Angeles Dodgers vs. the San Francisco Giants: Shohei Ohtani +8 Strikeouts

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San Francisco Giants vs Los Angeles Dodgers Picks