Jacksonville Jaguars vs Los Angeles Chargers Prediction & Picks - NFL

USA - NFL

Jacksonville Jaguars
11/16/25 13:00
Los Angeles Chargers

Prediction:

 

Under 43.5

-105
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 by Erik Gibbs | in NFL Picks

The Week 11 matchup between the Los Angeles Chargers and the Jacksonville Jaguars at EverBank Stadium brings together two teams headed in very different directions. Los Angeles rolls into this game at 7-3 and riding the momentum of a convincing 25-10 win over Pittsburgh, a performance that highlighted their balance on both sides of the ball. Jacksonville, meanwhile, is looking to steady itself after dropping a 36-29 shootout to Houston, a loss that pushed them to 5-4 and exposed lingering defensive issues that have cropped up repeatedly this season.

The Chargers have quietly built one of the more efficient offenses in the league. They rank seventh in passing yards per game, leaning on a consistent aerial attack that complements a top-10 rushing offense. That balance has helped them average 24 points per contest, a number that keeps them competitive even when the pace quickens. Defensively, Los Angeles has also shown real stability. They sit eighth in scoring defense, keeping opponents to just over 20 points per game. That combination of steady quarterback play, a reliable run game, and a defense that rarely breaks makes them one of the more complete teams through ten weeks.

Jacksonville's statistical profile tells a different story. While the Jaguars sit near the league's midpoint in both passing and rushing yardage, they lack the sharp execution that separates contenders from teams still trying to find their rhythm. Their scoring offense is slightly below league average, and their defense has struggled to get off the field in key moments, allowing more than 24 points per game. Last week's collapse against Houston, where they allowed 26 points in the fourth quarter alone, highlights just how volatile this group can be. Injuries to several top receivers also cloud their offensive outlook heading into Sunday.

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Jacksonville Jaguars vs Los Angeles Chargers Form

Table

Teams Pts P W L
4 Jacksonville Jaguars
0.765 17 13 4
9 Los Angeles Chargers
0.647 17 11 6

Jacksonville Jaguars and Los Angeles Chargers Latest Matches

Jacksonville Jaguars
Jacksonville Jaguars Latest matches
W W L L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 9, 2025 - NFL

Houston Texans
36 :  29
Jacksonville Jaguars

Nov 2, 2025 - NFL

Las Vegas Raiders
29 :  30
Jacksonville Jaguars

Oct 19, 2025 - NFL

Jacksonville Jaguars
7 :  35
Los Angeles Rams

Oct 12, 2025 - NFL

Jacksonville Jaguars
12 :  20
Seattle Seahawks

Oct 6, 2025 - NFL

Jacksonville Jaguars
31 :  28
Kansas City Chiefs

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 19, 2025 - NFL

Jacksonville Jaguars
7 :  35
Los Angeles Rams

Oct 12, 2025 - NFL

Jacksonville Jaguars
12 :  20
Seattle Seahawks

Oct 6, 2025 - NFL

Jacksonville Jaguars
31 :  28
Kansas City Chiefs

Sep 21, 2025 - NFL

Jacksonville Jaguars
17 :  10
Houston Texans

Sep 7, 2025 - NFL

Jacksonville Jaguars
26 :  10
Carolina Panthers

Dec 29, 2024 - NFL

Jacksonville Jaguars
20 :  13
Tennessee Titans
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 9, 2025 - NFL

Houston Texans
36 :  29
Jacksonville Jaguars

Nov 2, 2025 - NFL

Las Vegas Raiders
29 :  30
Jacksonville Jaguars

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 14, 2025 - NFL

Cincinnati Bengals
31 :  27
Jacksonville Jaguars

Jan 5, 2025 - NFL

Indianapolis Colts
26 :  23
Jacksonville Jaguars

Dec 8, 2024 - NFL

Tennessee Titans
6 :  10
Jacksonville Jaguars
Los Angeles Chargers
Los Angeles Chargers Latest matches
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 9, 2025 - NFL

Los Angeles Chargers
25 :  10
Pittsburgh Steelers

Nov 2, 2025 - NFL

Tennessee Titans
20 :  27
Los Angeles Chargers

Oct 23, 2025 - NFL

Los Angeles Chargers
37 :  10
Minnesota Vikings

Oct 19, 2025 - NFL

Los Angeles Chargers
24 :  38
Indianapolis Colts

Oct 12, 2025 - NFL

Miami Dolphins
27 :  29
Los Angeles Chargers

Oct 5, 2025 - NFL

Los Angeles Chargers
10 :  27
Washington Commanders
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 9, 2025 - NFL

Los Angeles Chargers
25 :  10
Pittsburgh Steelers

Oct 23, 2025 - NFL

Los Angeles Chargers
37 :  10
Minnesota Vikings

Oct 19, 2025 - NFL

Los Angeles Chargers
24 :  38
Indianapolis Colts

Oct 5, 2025 - NFL

Los Angeles Chargers
10 :  27
Washington Commanders

Sep 21, 2025 - NFL

Los Angeles Chargers
23 :  20
Denver Broncos

Sep 5, 2025 - NFL

Los Angeles Chargers
27 :  21
Kansas City Chiefs
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 2, 2025 - NFL

Tennessee Titans
20 :  27
Los Angeles Chargers

Oct 12, 2025 - NFL

Miami Dolphins
27 :  29
Los Angeles Chargers

Sep 28, 2025 - NFL

New York Giants
21 :  18
Los Angeles Chargers

Sep 15, 2025 - NFL

Las Vegas Raiders
9 :  20
Los Angeles Chargers

Jan 11, 2025 - NFL

Houston Texans
32 :  12
Los Angeles Chargers

Jan 5, 2025 - NFL

Las Vegas Raiders
20 :  34
Los Angeles Chargers

Jacksonville Jaguars against Los Angeles Chargers : Head to Head (H2H)

Jacksonville Jaguars

100 %

Los Angeles Chargers

0 %

Jan 14, 2023 - NFL

Jacksonville Jaguars
31 :  30
Los Angeles Chargers

Jacksonville Jaguars - Los Angeles Chargers Key Points

  1. The Over is 0-6 in the Jaguars’ last 6 games as underdogs after a road loss
  2. The Over is 0-4 in the last four Sunday games at EverBank Stadium
  3. The Jaguars are 3-0 in their last 3 November games as home underdogs vs. AFC teams
  4. The Chargers are 1-3 in their last 4 games as road favorites vs. AFC South teams
Up to $250 to bet on Jacksonville Jaguars - Los Angeles Chargers! 

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Our Jacksonville Jaguars vs Los Angeles Chargers Prediction

The historical matchup favors Los Angeles, holding a 9-4 edge in the regular season series. However, Jacksonville did deliver a dominant 38-10 win the last time these teams met in 2022. The question is whether the Jaguars, as currently constructed and significantly less healthy, can replicate anything close to that performance.

Totals trends point to another interesting layer. The Chargers have split their ten games in relation to the number but have hit the over in four of their last five overall, including each of their last two on the road. Jacksonville's pattern is more split: they have gone over in all four road games but stayed under in four of five at home. Given how leaky their defense has looked and how consistently the Chargers have moved the football, this matchup has the potential to turn into another high-scoring affair, especially if Jacksonville again struggles to contain explosive plays late.

With Los Angeles healthier, more consistent, and better equipped to control the tempo, the Chargers enter Week 11 as the more trustworthy side. Jacksonville will need a cleaner defensive effort and a more stable fourth quarter than they've shown in recent weeks to avoid falling back into the AFC pack. Our prediction for the Jacksonville Jaguars vs. Los Angeles Chargers: Under 43.5 points.

Prediction:

 

Under 43.5

-105
$250 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Jacksonville Jaguars vs Los Angeles Chargers Picks