St. Louis Cardinals vs Los Angeles Angels Prediction & Picks - MLB

Prediction published on 3/31/25, 4:25 PM  by Carlos Zabala | Modified on 2/16/26 at 4:25 PM in MLB Picks

The Cardinals exceeded expectations in the opening series by sweeping the Twins in three games in St. Louis. However, the Cardinals ultimately won each game by two or more runs. They will stay at Busch Stadium to host the Angels, who barely managed to take the series from the White Sox, beating them 3-2 in the final game in Chicago.

The series finale ended 9-2 with the Cards beating the Twins, so a $100 ML bet on each Cardinals game this season would have generated a return of +$302. This is the first time the Cardinals have started a season 3-0 since they did so in 2006, and they are four games away from matching their career-best record of seven wins to start a season, which they achieved in 1962.

Veteran Miles Mikolas begins another season as a Cardinal, earning a spot in the rotation. Against the Marlins, on March 18th in spring training, he pitched six innings, allowing three runs per game, striking out four, and throwing two home runs.