Lorenzo Musetti vs Novak Djokovic Prediction & Picks - ATP Australian Open

ATP - ATP Australian Open

ATP 11 Italy
Lorenzo Musetti
1/27/26 23:30
ATP 4 Serbia
Novak Djokovic

Prediction:

 

Novak Djokovic -4.5 Games

-125
$250 offered for betting!

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 by Lou Aguila | in ATP Australian Open Picks

Novak Djokovic of Serbia looks to inch closer to Grand Slam No.25 as he seeks his spot in the semifinals of the 2026 Australian Open against Lorenzo Musetti of Italy late Tuesday evening (US Time).

Recommended Pick:

Potential Payout: Novak Djokovic -4.5 Games

Current Form: $900 for every $500 Bet (-125)

Djokovic has breezed through to the quarterfinals with some vintage form and a little bit of luck. Djokovic dispatched his first three opponents (Pedro Martinez, Francisco Maestrelli, and Botic Van De Zandschulp) in straight sets before receiving a walkover win in the fourth round after his scheduled opponent, Jakub Mensik, withdrew from the tournament because of an abdominal muscle injury.

Musetti also reached the quarterfinals of the 2026 Australian Open for the first time after putting on a virtuoso performance against Taylor Fritz of the United States 6-2, 7-5, 6-4. Coming off a grueling five-set battle with Tomas Machac of the Czech Republic, Musetti was expected to come out flat against Fritz, who is considered one of the best hard-court players on the tour outside the Sincaraz tandem. Instead, the Italian brought out his best game on the concrete, bombarding Sinner with 13 aces and 32 winners.

Up to $250 to bet on Lorenzo Musetti - Novak Djokovic! 

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Lorenzo Musetti vs Novak Djokovic Form

Lorenzo Musetti and Novak Djokovic Latest Matches

Lorenzo Musetti Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jan 25, 2026 - ATP Australian Open

Lorenzo Musetti
3 :  0
Taylor Fritz

Jan 23, 2026 - ATP Australian Open

Lorenzo Musetti
3 :  2
Tomas Machac

Jan 21, 2026 - ATP Australian Open

Lorenzo Musetti
3 :  0
Lorenzo Sonego

Jan 11, 2026 - Hong Kong Open

Lorenzo Musetti
0 :  2
Alexander Bublik

Jan 10, 2026 - Hong Kong Open

Lorenzo Musetti
2 :  1
Andrey Rublev

Jan 9, 2026 - Hong Kong Open

Lorenzo Musetti
2 :  0
Coleman Wong
Novak Djokovic Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Jan 24, 2026 - ATP Australian Open

Botic Van De Zandschulp
0 :  3
Novak Djokovic

Jan 21, 2026 - ATP Australian Open

Francesco Maestrelli
0 :  3
Novak Djokovic

Jan 19, 2026 - ATP Australian Open

Pedro Martinez
0 :  3
Novak Djokovic

Nov 8, 2025 - ATP Athens Hellenic Championship

Novak Djokovic
2 :  1
Lorenzo Musetti

Nov 7, 2025 - ATP Athens Hellenic Championship

Novak Djokovic
2 :  0
Yannick Hanfmann

Nov 6, 2025 - ATP Athens Hellenic Championship

Novak Djokovic
2 :  0
Nuno Borges

Lorenzo Musetti against Novak Djokovic : Head to Head (H2H)

Lorenzo Musetti

0 %

Novak Djokovic

100 %

Nov 8, 2025 - ATP Athens Hellenic Championship

Novak Djokovic
2 :  1
Lorenzo Musetti

Mar 25, 2025 - ATP Miami

Lorenzo Musetti
0 :  2
Novak Djokovic

Aug 2, 2024 - Olympic Tournament

Novak Djokovic
2 :  0
Lorenzo Musetti

Jul 12, 2024 - ATP Wimbledon Championships

Lorenzo Musetti
0 :  3
Novak Djokovic

Jun 1, 2024 - ATP French Open

Novak Djokovic
3 :  2
Lorenzo Musetti

Apr 11, 2024 - ATP Monte Carlo Masters

Novak Djokovic
2 :  0
Lorenzo Musetti

Lorenzo Musetti - Novak Djokovic Key Points

  1. Lorenzo Musetti is winning 73 percent of his first serves at the 2026 Australian Open.
  2. Lorenzo Musetti has saved 71 percent of breakpoints at the 2026 Australian Open.
  3. Novak Djokovic has taken a three-day rest following Jakub Mensik’s withdrawal.
  4. Novak Djokovic is 9-1 vs. Lorenzo Musetti.
Up to $250 to bet on Lorenzo Musetti - Novak Djokovic! 

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Our Lorenzo Musetti vs Novak Djokovic Prediction

Fearless Forecast: Novak Djokovic powers past Lorenzo Musetti 6-4, 7-5, 6-7, 6-3

Reason: Perhaps the most logical explanation why Djokovic is my confident pick to win and cover the spread is the three-day rest he gained after Jakub Mensik gave him a walkover win. Getting this much rest in the final stretch of the Australian Open is crucial for the aging body of the 38-year-old Djokovic.

Now that Nole is healthy and refreshed, I feel the window for Grand Slam No.25 has gotten larger because of the fact that you’ve got Djokovic playing at his near full strength. This is bad news for Musetti, who only has one win in 10 matches against the Serb. The last time these two met, Djokovic outlasted Musetti 4-6, 6-3, 7-5 in the final of the 2025 Hellenic Championship.

Our betting prediction for Novak Djokovic vs. Lorenzo Musetti: Novak Djokovic -4.5 Games

Prediction:

 

Novak Djokovic -4.5 Games

-125
$250 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Lorenzo Musetti vs Novak Djokovic Picks