James Madison Dukes vs Louisville Cardinals Prediction & Picks - NCAA
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by Matt Lowrimore | in NCAA Picks
Week 2 of the college football season will kick off on Friday with a handful of games, one of which will see the James Madison Dukes, out of the Sun Belt, take on the Louisville Cardinals, out of the ACC. Let’s take a look at the match statistics and predictions for this game between the Dukes and the Cardinals.
James Madison enters this game with a record of 1-0, having beaten the Weber State Wildcats in Week 1 of the season by a score of 45-10. The Dukes were dominant in all phases, totaling 458 yards, while allowing just 148 yards. James Madison quarterback Alonza Barnett III threw for 130 yards and one touchdown, while George Pettaway was the leading rusher with 99 yards on 10 carries.
As for Louisville, they enter this game with a record of 1-0, having beaten the Eastern Kentucky Colonels in Week 1 by a score of 51-17. The Cardinals totaled 545 yards of offense, while allowing just 150 yards. Louisville quarterback Miller Moss threw for 223 yards, one touchdown, and two interceptions, while Isaac Brown led the team in rushing with 126 yards and two touchdowns.
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James Madison Dukes vs Louisville Cardinals Form
Table
| Teams | % | P | W | D | L |
|---|---|---|---|---|---|
|
1
|
1 | 6 | 6 | 0 | 0 |
|
11
|
0.5 | 8 | 4 | 0 | 4 |
James Madison Dukes and Louisville Cardinals Latest Matches
1/1 (100%)
0/1 (0%)
0/1 (0%)
Aug 30, 2025 - NCAA
1/1 (100%)
0/1 (0%)
0/1 (0%)
Aug 30, 2025 - NCAA
2/3 (67%)
0/3 (0%)
1/3 (33%)
Aug 30, 2025 - NCAA
Dec 31, 2024 - NCAA Division I, FBS, Playoffs
Sep 28, 2024 - NCAA
1/1 (100%)
0/1 (0%)
0/1 (0%)
Aug 30, 2025 - NCAA
1/2 (50%)
0/2 (0%)
1/2 (50%)
Dec 31, 2024 - NCAA Division I, FBS, Playoffs
Sep 28, 2024 - NCAA
James Madison Dukes - Louisville Cardinals Key Points
- The Dukes forced three turnovers in Week 1
- The Dukes committed 6 penalties for 75 yards in Week 1
- The Cardinals turned it over three times in Week 1
- The Cardinals committed 12 penalties for 106 yards in Week 1
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Our James Madison Dukes vs Louisville Cardinals Prediction
While both teams easily won their Week 1 matchups, two areas could be the difference in this matchup in Week 2. That being turnovers and penalties. In both cases, Louisville struggled in these areas.
The Cardinals’ quarterbacks threw a total of three interceptions against Eastern Kentucky, which includes two by starting quarterback and USC transfer Miller Moss. Secondly, Louisville committed 12 penalties for 106 yards, which could be a major problem going forward if they cannot clean this up.
James Madison, on the other hand, has had some recent success when playing teams from the ACC. Though this was a full season ago, the Dukes made headlines by beating North Carolina by a score of 70-50. This game is unlikely to produce a similar score; however, with Louisville having already shown some problems with turnovers and penalties, our James Madison Dukes vs Louisville Cardinals prediction is: James Madison Dukes +14.5 Alternate Spread.All tips are fully researched and given in good faith, but profits cannot be guaranteed.
