Los Angeles Rams vs Indianapolis Colts Prediction & Picks - NFL

USA - NFL

Los Angeles Rams
9/28/25 16:05
Indianapolis Colts

Prediction:

 

Colts +3.5

-105
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Travis Pulver | in NFL Picks

The Los Angeles Rams will try to get back on the right side of the scoreboard this week when they host Daniel Jones and the undefeated Indianapolis Colts. Gametime at SoFI Stadium in Inglewood, CA, is scheduled for 4:05 p.m. EST on Sunday, Sept. 28.

LA is coming off a disappointing loss to the Eagles in Philadelphia. After leading for most of the game, they fell behind by one when the Eagles scored the go-ahead touchdown with 1:48 on the clock. That was enough time for the Rams to get into position for a 44-yard field goal as time expired—which was blocked and returned the other way for a touchdown. As for the Colts, Daniel Jones and the Indy offense has been one of the more pleasant surprises of the season so far. They are undefeated (3-0) and averaging 34.3 points per game, second only to the Ravens (37 points per game) and tied with Detroit. While many seem to be waiting for hi to fail, Daniel Jones has played extremely well. He has the fourth most passing yards in the league through Week 3 and the sixth best passer rating. However, his nay sayers are quick to say that he’s generated those stats against weak teams (and they were weak, i.e., Tennessee and Miami; Denver wasn’t weak but the Colts should have lost that one).

Los Angeles Rams vs Indianapolis Colts Form

Table

Teams Pts P W L
5 Los Angeles Rams
0.706 17 12 5
20 Indianapolis Colts
0.471 17 8 9

Los Angeles Rams and Indianapolis Colts Latest Matches

Los Angeles Rams
Los Angeles Rams Latest matches
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 21, 2025 - NFL

Philadelphia Eagles
33 :  26
Los Angeles Rams

Sep 14, 2025 - NFL

Tennessee Titans
19 :  33
Los Angeles Rams

Sep 7, 2025 - NFL

Los Angeles Rams
14 :  9
Houston Texans

Jan 19, 2025 - NFL

Philadelphia Eagles
28 :  22
Los Angeles Rams

Jan 13, 2025 - NFL

Los Angeles Rams
27 :  9
Minnesota Vikings

Jan 5, 2025 - NFL

Los Angeles Rams
25 :  30
Seattle Seahawks
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 7, 2025 - NFL

Los Angeles Rams
14 :  9
Houston Texans

Jan 13, 2025 - NFL

Los Angeles Rams
27 :  9
Minnesota Vikings

Jan 5, 2025 - NFL

Los Angeles Rams
25 :  30
Seattle Seahawks

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals

Dec 8, 2024 - NFL

Los Angeles Rams
44 :  42
Buffalo Bills

Nov 24, 2024 - NFL

Los Angeles Rams
20 :  37
Philadelphia Eagles
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 21, 2025 - NFL

Philadelphia Eagles
33 :  26
Los Angeles Rams

Sep 14, 2025 - NFL

Tennessee Titans
19 :  33
Los Angeles Rams

Jan 19, 2025 - NFL

Philadelphia Eagles
28 :  22
Los Angeles Rams

Dec 22, 2024 - NFL

New York Jets
9 :  19
Los Angeles Rams

Dec 12, 2024 - NFL

San Francisco 49ers
6 :  12
Los Angeles Rams

Nov 17, 2024 - NFL

New England Patriots
22 :  28
Los Angeles Rams
Indianapolis Colts
Indianapolis Colts Latest matches
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 21, 2025 - NFL

Tennessee Titans
20 :  41
Indianapolis Colts

Sep 14, 2025 - NFL

Indianapolis Colts
29 :  28
Denver Broncos

Sep 7, 2025 - NFL

Indianapolis Colts
33 :  8
Miami Dolphins

Jan 5, 2025 - NFL

Indianapolis Colts
26 :  23
Jacksonville Jaguars

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 22, 2024 - NFL

Indianapolis Colts
38 :  30
Tennessee Titans
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 14, 2025 - NFL

Indianapolis Colts
29 :  28
Denver Broncos

Sep 7, 2025 - NFL

Indianapolis Colts
33 :  8
Miami Dolphins

Jan 5, 2025 - NFL

Indianapolis Colts
26 :  23
Jacksonville Jaguars

Dec 22, 2024 - NFL

Indianapolis Colts
38 :  30
Tennessee Titans

Nov 24, 2024 - NFL

Indianapolis Colts
6 :  24
Detroit Lions

Nov 10, 2024 - NFL

Indianapolis Colts
20 :  30
Buffalo Bills
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 21, 2025 - NFL

Tennessee Titans
20 :  41
Indianapolis Colts

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 15, 2024 - NFL

Denver Broncos
31 :  13
Indianapolis Colts

Dec 1, 2024 - NFL

New England Patriots
24 :  25
Indianapolis Colts

Nov 17, 2024 - NFL

New York Jets
27 :  28
Indianapolis Colts

Nov 3, 2024 - NFL

Minnesota Vikings
21 :  13
Indianapolis Colts

Los Angeles Rams - Indianapolis Colts Key Points

  1. Colts lead the all-time series vs. the Rams 23-22-2.
  2. The Rams have won the last four meetings; the last game was on 10/01/2023 which the Rams won in OT.
  3. Colts opponents have a combined record of 1-8 while Rams opponents have a combined record of 2-7.
  4. Betting Public: 80% of spread tickets but 47% of the handle are on the Colts.

Our Los Angeles Rams vs Indianapolis Colts Prediction

The big question may be whether or not you believe in Danny Dimes, but that is not the only thing to consider. For one, the Colts defense has been playing lights out and will make it hard on the Rams offense to get on track. Also, while the Rams gave the Eagles a solid fight, they still lost and their opponents have not been impressive either. I’m going to choose to believe Daniel Jones is legit and that the Colts will keep this game close if not win outright.

Our Colts vs. Rams Pick: Indianapolis +3.5

Prediction:

 

Colts +3.5

-105
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Los Angeles Rams vs Indianapolis Colts Picks