Indiana Hoosiers vs Penn State Nittany Lions Prediction & Picks - NCAA

USA - NCAA

Indiana Hoosiers
11/8/25 12:00
Penn State Nittany Lions

Prediction:

 

Indiana -14.5

-110
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 by Travis Pulver in NCAA Picks

The No. 2 Indiana Hoosiers will go for the program’s first win in Happy Valley when they take on the struggling Penn State Nittany Lions at Beaver Stadium in University Park, PA, Saturday afternoon. Kickoff for this Big Ten contest is scheduled for 12 p.m. EST. Fans can follow the game on Fox.

Expectations were high for the Nittany Lions coming into the season, and it looked like they might live up to them as they got off to a 3-0 start. But then things quickly fell apart as the team lost five in a row to start Big Ten play, losing their starting quarterback to a season-ending injury and head coach James Franklin (fired). As for Indiana, the journey has been the exact opposite, as they have dominated the competition on both sides of the ball. The Hoosiers have been flying high all season en route to a 9-0 start, becoming the No. 2 team in the first CFP poll. Quarterback Fernando Mendoza has developed into a Heisman front-runner and the popular choice to go No. 1 in the next NFL draft. Should Indiana meet Ohio State in the Big Ten title game as expected, it could be the most anticipated game of the season.

Indiana Hoosiers vs Penn State Nittany Lions Form

Table

Teams % P W D L
1
Indiana Hoosiers
Indiana Hoosiers
1 6 6 0 0
15
Penn State Nittany Lions
Penn State Nittany Lions
0 5 0 0 5

Indiana Hoosiers and Penn State Nittany Lions Latest Matches

Indiana Hoosiers
Indiana Hoosiers Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 1, 2025 - NCAA

Indiana Hoosiers
55 :  10
Maryland Terrapins

Oct 25, 2025 - NCAA

UCLA Bruins
6 :  56
Indiana Hoosiers

Oct 18, 2025 - NCAA

Michigan State Spartans
13 :  38
Indiana Hoosiers

Oct 11, 2025 - NCAA

Indiana Hoosiers
30 :  20
Oregon Ducks

Sep 27, 2025 - NCAA

Indiana Hoosiers
20 :  15
Iowa Hawkeyes

Sep 20, 2025 - NCAA

Illinois Fighting Illini
10 :  63
Indiana Hoosiers
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Oct 25, 2025 - NCAA

UCLA Bruins
6 :  56
Indiana Hoosiers

Oct 18, 2025 - NCAA

Michigan State Spartans
13 :  38
Indiana Hoosiers

Sep 20, 2025 - NCAA

Illinois Fighting Illini
10 :  63
Indiana Hoosiers

Sep 12, 2025 - NCAA

Indiana State Sycamores
0 :  73
Indiana Hoosiers

Sep 6, 2025 - NCAA

Kennesaw State Owls
9 :  56
Indiana Hoosiers

Aug 30, 2025 - NCAA

Old Dominion Monarchs
14 :  27
Indiana Hoosiers
W L L W W W
Victories

3/5 (60%)

Draw

0/5 (0%)

Defeats

2/5 (40%)

Nov 1, 2025 - NCAA

Indiana Hoosiers
55 :  10
Maryland Terrapins

Oct 11, 2025 - NCAA

Indiana Hoosiers
30 :  20
Oregon Ducks

Sep 27, 2025 - NCAA

Indiana Hoosiers
20 :  15
Iowa Hawkeyes

Dec 20, 2024 - NCAA

Indiana Hoosiers
17 :  27
Notre Dame Fighting Irish

Nov 23, 2024 - NCAA

Indiana Hoosiers
15 :  38
Ohio State Buckeyes
Penn State Nittany Lions
Penn State Nittany Lions Latest matches
W L L L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Nov 1, 2025 - NCAA

Penn State Nittany Lions
14 :  38
Ohio State Buckeyes

Oct 18, 2025 - NCAA

Penn State Nittany Lions
24 :  25
Iowa Hawkeyes

Oct 11, 2025 - NCAA

Northwestern Wildcats
22 :  21
Penn State Nittany Lions

Oct 4, 2025 - NCAA

Penn State Nittany Lions
37 :  42
UCLA Bruins

Sep 27, 2025 - NCAA

Oregon Ducks
30 :  24
Penn State Nittany Lions

Sep 13, 2025 - NCAA

Villanova Wildcats
6 :  52
Penn State Nittany Lions
L W W W L L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 11, 2025 - NCAA

Northwestern Wildcats
22 :  21
Penn State Nittany Lions

Sep 27, 2025 - NCAA

Oregon Ducks
30 :  24
Penn State Nittany Lions

Sep 13, 2025 - NCAA

Villanova Wildcats
6 :  52
Penn State Nittany Lions

Sep 6, 2025 - NCAA

FIU Panthers
0 :  34
Penn State Nittany Lions

Aug 30, 2025 - NCAA

Nevada Wolf Pack
11 :  46
Penn State Nittany Lions

Jan 9, 2025 - NCAA

Notre Dame Fighting Irish
27 :  24
Penn State Nittany Lions
W L W L L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 1, 2025 - NCAA

Penn State Nittany Lions
14 :  38
Ohio State Buckeyes

Oct 18, 2025 - NCAA

Penn State Nittany Lions
24 :  25
Iowa Hawkeyes

Oct 4, 2025 - NCAA

Penn State Nittany Lions
37 :  42
UCLA Bruins

Dec 31, 2024 - NCAA

Penn State Nittany Lions
31 :  14
Boise State Broncos

Dec 7, 2024 - NCAA

Penn State Nittany Lions
37 :  45
Oregon Ducks

Nov 23, 2024 - NCAA

Penn State Nittany Lions
26 :  25
Minnesota Golden Gophers

Indiana Hoosiers - Penn State Nittany Lions Key Points

  1. Penn State has dominated the all-time series vs. Indiana going 25-2; both IU wins were at home.
  2. Indiana is 6-3 ATS while Penn State is 1-7.
  3. The OVER is 6-2 for Penn State and 6-3 for Indiana.
  4. Betting Public: 66% of spread tickets and 63% of the handle are on the Hoosiers (-14.5).

Our Indiana Hoosiers vs Penn State Nittany Lions Prediction

Penn State is struggling hard this season, but the Nittany Lions still have a pretty solid defense. However, while it may slow Indiana down in the first quarter (half at the most), there is no way the Nittany Lions keep up with the Hoosiers. Indiana has the No. 1 scoring offense in the country and the No. 3 scoring defense. Penn State’s defense will eventually wear down like everyone else.

Our Indiana vs. Penn State Pick: Indiana -14.5

Prediction:

 

Indiana -14.5

-110
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Indiana Hoosiers vs Penn State Nittany Lions Picks