St. Louis Cardinals vs Houston Astros Prediction & Picks - MLB

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St. Louis Cardinals
4/16/25 13:15
Houston Astros

Prediction:

 

Cardinals will win

 

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 by Lou Aguila in MLB Picks

The Houston Astros aim for their first win streak this season in Wednesday’s series-finale against the St. Louis Cardinals at Busch Stadium.

The up and down pattern continues for the Astros, who bounced back from 3-8 loss in Game 1 vs. the Cardinals by bagging their first team shutout win of the season. Hunter Brown was sensational on the mound for six innings, allowing four hits and two walks to garner his second consecutive shutout. Houston is sporting a 3.92 ERA, which falls in the middle of the pack, but their bullpen has figured it out in the last five games, surrendering a 1.42 ERA.

The Game 2 loss snapped the Cardinals’ two-game winning run, absorbing their first shutout loss this year. Batting .280 with 5.3 runs per game, St. Louis could only produce six hits against the Astros’ impeccable pitching on Tuesday.

St. Louis Cardinals vs Houston Astros Form

Table

Teams Pts P W L
12 Houston Astros
0.537 162 87 75
20 St. Louis Cardinals
0.481 162 78 84

St. Louis Cardinals and Houston Astros Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 15, 2025 - MLB

St. Louis Cardinals
0 :  2
Houston Astros

Apr 14, 2025 - MLB

St. Louis Cardinals
8 :  3
Houston Astros

Apr 13, 2025 - MLB

St. Louis Cardinals
7 :  0
Philadelphia Phillies

Apr 12, 2025 - MLB

St. Louis Cardinals
1 :  4
Philadelphia Phillies

Apr 11, 2025 - MLB

St. Louis Cardinals
2 :  0
Philadelphia Phillies

Apr 9, 2025 - MLB

Pittsburgh Pirates
2 :  1
St. Louis Cardinals
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 15, 2025 - MLB

St. Louis Cardinals
0 :  2
Houston Astros

Apr 14, 2025 - MLB

St. Louis Cardinals
8 :  3
Houston Astros

Apr 13, 2025 - MLB

St. Louis Cardinals
7 :  0
Philadelphia Phillies

Apr 12, 2025 - MLB

St. Louis Cardinals
1 :  4
Philadelphia Phillies

Apr 11, 2025 - MLB

St. Louis Cardinals
2 :  0
Philadelphia Phillies

Apr 2, 2025 - MLB

St. Louis Cardinals
12 :  5
Los Angeles Angels
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 9, 2025 - MLB

Pittsburgh Pirates
2 :  1
St. Louis Cardinals

Apr 8, 2025 - MLB

Pittsburgh Pirates
3 :  5
St. Louis Cardinals

Apr 7, 2025 - MLB

Pittsburgh Pirates
8 :  4
St. Louis Cardinals

Apr 6, 2025 - MLB

Boston Red Sox
18 :  7
St. Louis Cardinals

Apr 4, 2025 - MLB

Boston Red Sox
13 :  9
St. Louis Cardinals

Sep 13, 2024 - MLB

Toronto Blue Jays
4 :  3
St. Louis Cardinals
Houston Astros
Houston Astros Latest matches
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 15, 2025 - MLB

St. Louis Cardinals
0 :  2
Houston Astros

Apr 14, 2025 - MLB

St. Louis Cardinals
8 :  3
Houston Astros

Apr 13, 2025 - MLB

Houston Astros
7 :  3
Los Angeles Angels

Apr 12, 2025 - MLB

Houston Astros
1 :  4
Los Angeles Angels

Apr 11, 2025 - MLB

Houston Astros
14 :  3
Los Angeles Angels

Apr 9, 2025 - MLB

Seattle Mariners
7 :  6
Houston Astros
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 13, 2025 - MLB

Houston Astros
7 :  3
Los Angeles Angels

Apr 12, 2025 - MLB

Houston Astros
1 :  4
Los Angeles Angels

Apr 11, 2025 - MLB

Houston Astros
14 :  3
Los Angeles Angels

Apr 2, 2025 - MLB

Houston Astros
3 :  6
San Francisco Giants

Apr 1, 2025 - MLB

Houston Astros
1 :  3
San Francisco Giants

Mar 31, 2025 - MLB

Houston Astros
2 :  7
San Francisco Giants
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 15, 2025 - MLB

St. Louis Cardinals
0 :  2
Houston Astros

Apr 14, 2025 - MLB

St. Louis Cardinals
8 :  3
Houston Astros

Apr 9, 2025 - MLB

Seattle Mariners
7 :  6
Houston Astros

Apr 8, 2025 - MLB

Seattle Mariners
1 :  2
Houston Astros

Apr 7, 2025 - MLB

Seattle Mariners
4 :  3
Houston Astros

Apr 5, 2025 - MLB

Minnesota Twins
6 :  1
Houston Astros

St. Louis Cardinals against Houston Astros : Head to Head (H2H)

St. Louis Cardinals

50 %

Houston Astros

50 %

Apr 15, 2025 - MLB

St. Louis Cardinals
0 :  2
Houston Astros

Apr 14, 2025 - MLB

St. Louis Cardinals
8 :  3
Houston Astros

Jun 5, 2024 - MLB

Houston Astros
2 :  4
St. Louis Cardinals

Jun 4, 2024 - MLB

Houston Astros
8 :  5
St. Louis Cardinals

St. Louis Cardinals - Houston Astros Key Points

  1. Houston are 1-4 SU in their last 5 games against an opponent in the National League.
  2. Houston are 5-2 SU in their last 7 games when playing on the road against St. Louis.
  3. St. Louis are 2-5 SU in their last 7 games when playing at home against Houston.
  4. St. Louis are 1-4 SU in their last 5 games against an opponent in the American League.

Our St. Louis Cardinals vs Houston Astros Prediction

Houston are 5-2 SU in their last 7 games when playing on the road against St. Louis. However, I think the Cardinals will come out of the gates strong in Game 3 after a horrific game at the plate on Wednesday. There’s no way the Cardinals will be shut out for two days in a row, especially for a team that ranks first in batting average (.287) and third in total runs tally (90). The Cards have promoted relief pitcher Steven Matz as the starter on Wednesday. Although I am not expecting him to pitch beyond three innings, St. Louis would just be fine because their batting will deal heavy damage anyway against Astros starter Ronel Blanco, who has a 4.37 ERA in his last five starts. Our betting prediction for St. Louis Cardinals vs. Houston Astros: Cardinals will win.

Prediction:

 

Cardinals will win

 

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

St. Louis Cardinals vs Houston Astros Picks