Philadelphia Phillies vs Houston Astros Prediction & Picks - MLB
USA - MLB
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Matt Lowrimore in MLB Picks
A massive 15-game MLB slate is scheduled for Wednesday, one of which will include an interleague matchup between the Philadelphia Phillies and the Houston Astros. Let’s take a look at the match statistics and predictions for this game between the Phillies and the Astros.
Houston enters this game a handful of games above .500, yet is still currently in first place in the American League West Division. Set to start this game for the Astros is Hunter Brown, who has an ERA of 3.31. To go along with his solid numbers overall, Brown has been much more reliable on the road, a trend that should continue against the Phillies.
As for Philadelphia, they enter this game with one of the better records in the league; however, they are currently in second place in the National League East Division. Starting this game for the Phillies will be Cristopher Sanchez, who has an ERA of 2.58. Sanchez rarely gives up runs when pitching at home, suggesting that this game looks likely to be a pitchers’ duel.
Limited Offer. Currently at DraftKings
Philadelphia Phillies vs Houston Astros Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
6
|
0.559 | 145 | 81 | 64 |
|
12
|
0.51 | 145 | 74 | 71 |
Philadelphia Phillies and Houston Astros Latest Matches
2/6 (33%)
4/6 (67%)
Sep 8, 2026 - MLB
Sep 7, 2026 - MLB
Sep 6, 2026 - MLB
Sep 5, 2026 - MLB
Sep 4, 2026 - MLB
Sep 2, 2026 - MLB
3/6 (50%)
3/6 (50%)
Sep 8, 2026 - MLB
Sep 7, 2026 - MLB
Sep 6, 2026 - MLB
Sep 5, 2026 - MLB
Sep 4, 2026 - MLB
Aug 23, 2026 - MLB
5/6 (83%)
1/6 (17%)
Sep 2, 2026 - MLB
Sep 1, 2026 - MLB
Aug 31, 2026 - MLB
Aug 30, 2026 - MLB
Aug 29, 2026 - MLB
Aug 28, 2026 - MLB
4/6 (67%)
2/6 (33%)
Sep 8, 2026 - MLB
Sep 6, 2026 - MLB
Sep 5, 2026 - MLB
Sep 4, 2026 - MLB
Sep 3, 2026 - MLB
Sep 2, 2026 - MLB
3/6 (50%)
3/6 (50%)
Sep 6, 2026 - MLB
Sep 5, 2026 - MLB
Sep 4, 2026 - MLB
Sep 3, 2026 - MLB
Sep 2, 2026 - MLB
Sep 1, 2026 - MLB
4/6 (67%)
2/6 (33%)
Sep 8, 2026 - MLB
Aug 30, 2026 - MLB
Aug 29, 2026 - MLB
Aug 28, 2026 - MLB
Aug 27, 2026 - MLB
Aug 26, 2026 - MLB
Philadelphia Phillies against Houston Astros : Head to Head (H2H)
17 %
83 %
Sep 8, 2026 - MLB
Jun 26, 2025 - MLB
Jun 25, 2025 - MLB
Jun 24, 2025 - MLB
Aug 28, 2024 - MLB
Aug 27, 2024 - MLB
Philadelphia Phillies - Houston Astros Key Points
- Hunter Brown has an ERA of 3.31 this season
- Hunter Brown has an ERA of 2.67 on the road this season
- Cristopher Sanchez has an ERA of 2.58 this season
- Cristopher Sanchez has an ERA of 1.83 at home this season
Limited Offer. Currently at DraftKings
Our Philadelphia Phillies vs Houston Astros Prediction
The Phillies are the heavy favorite in this game; however, the under looks to be the best betting option. This is because of the home/away splits between the two starting pitchers. Brown has made just six away starts this season, but has only allowed 11 runs (10 earned) over 33.2 innings. Sanchez, on the other hand, has made 17 home starts, in which he has allowed just 26 runs (22 earned) over 108.0 innings.
Both offenses have been able to consistently score this season, but because both starters have also consistently been elite, our Philadelphia Phillies vs Houston Astros prediction is: Under 8 Total Runs.
A Welcome Bonus for Philadelphia Phillies vs Houston Astros!

Looking to place a bet on Philadelphia Phillies vs Houston Astros? For this MLB match, DraftKings will treat you to an exclusive offer: $200 in bonus bets, no promo code needed! Take advantage while you still can!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.