Philadelphia Phillies vs Houston Astros Prediction & Picks - MLB

Prediction published on 9/8/26, 10:10 AM  by Travis Pulver in MLB Picks

The Houston Astros (73-71, 36-33 Away) will try to get things turned around on the road against the Philadelphia Phillies (81-63, 40-32 Home) after losing their last two games at home against Arizona. First Pitch at Citizens Bank Park in the City of Brotherly Love for this AL vs. NL battle is scheduled for 6:40 p.m. EST, with coverage provided by MLB.TV.

With just a two-game lead over the Rangers in the AL West race after losing their last two, the Astros would love to get a win and widen that gap. Of course, that is not going to be easy against a Phillies team that is just four games back of the Braves in the NL East.

Hayden Wesneski is scheduled to get the start for the Astros. Wesneski has gone 4-1 in seven starts with a 3.18 ERA and a 1.06 WHIP. Teams have hit just .200 against him. He is undefeated on the road, going 2-0 in three starts, with a 3.57 ERA and a .238 OBA.

As for the Phillies, Philadelphia is expected to go with Andrew Painter on the mound. Jhe jas gone 3-8 this season in 21 appearances (19 starts) with a 5.55 ERA and 1.37 WHIP. Teams have hit .263 against him. At home, he has gone 2-5 in 10 appearances (nine starts) with a 5.81 ERA and a .267 OBA.