Minnesota Twins vs Houston Astros Prediction & Picks - MLB

USA - MLB

Minnesota Twins
5/20/26 13:40
Houston Astros

Prediction:

 

Minnesota Twins ML

-156
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 by Matt Lowrimore | in MLB Picks

All 30 teams are scheduled to be in action on Wednesday, which will include an American League matchup between the Minnesota Twins and the Houston Astros. Let’s take a look at the match statistics and predictions for this game between the Twins and the Astros.

It is no secret that Houston is having one of their worst starts to a season in recent years. The Astros are well below .500 and have already dug themselves a hole in the AL West division. Game 3 of this series will not be any easier, as Houston is scheduled to start Mike Burrows. He has a record of 2-5 this season and an ERA of 5.72. 

As for Minnesota, they have not been much better than Houston to begin the season. That said, they look to be in a favorable spot for Game 3, as the Twins are scheduled to start Joe Ryan. He has a record of 2-3 this season, but has an ERA of 3.20. The good news is that Ryan has been excellent at home, giving the Twins a good chance to pick up a much-needed win in this matchup.

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Minnesota Twins vs Houston Astros Form

Table

Teams Pts P W L
12 Houston Astros
0.504 119 60 59
16 Minnesota Twins
0.492 120 59 61

Minnesota Twins and Houston Astros Latest Matches

Minnesota Twins
Minnesota Twins Latest matches
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 19, 2026 - MLB

Minnesota Twins
1 :  2
Houston Astros

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

May 17, 2026 - MLB

Minnesota Twins
5 :  4
Milwaukee Brewers

May 16, 2026 - MLB

Minnesota Twins
1 :  2
Milwaukee Brewers

May 15, 2026 - MLB

Minnesota Twins
2 :  3
Milwaukee Brewers

May 14, 2026 - MLB

Minnesota Twins
9 :  1
Miami Marlins
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 19, 2026 - MLB

Minnesota Twins
1 :  2
Houston Astros

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

May 17, 2026 - MLB

Minnesota Twins
5 :  4
Milwaukee Brewers

May 16, 2026 - MLB

Minnesota Twins
1 :  2
Milwaukee Brewers

May 15, 2026 - MLB

Minnesota Twins
2 :  3
Milwaukee Brewers

May 14, 2026 - MLB

Minnesota Twins
9 :  1
Miami Marlins
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 10, 2026 - MLB

Cleveland Guardians
4 :  5
Minnesota Twins

May 9, 2026 - MLB

Cleveland Guardians
1 :  2
Minnesota Twins

May 8, 2026 - MLB

Cleveland Guardians
6 :  4
Minnesota Twins

May 7, 2026 - MLB

Washington Nationals
7 :  5
Minnesota Twins

May 6, 2026 - MLB

Washington Nationals
15 :  2
Minnesota Twins

May 5, 2026 - MLB

Washington Nationals
3 :  11
Minnesota Twins
Houston Astros
Houston Astros Latest matches
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 19, 2026 - MLB

Minnesota Twins
1 :  2
Houston Astros

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

May 17, 2026 - MLB

Houston Astros
0 :  8
Texas Rangers

May 16, 2026 - MLB

Houston Astros
4 :  1
Texas Rangers

May 15, 2026 - MLB

Houston Astros
2 :  0
Texas Rangers

May 14, 2026 - MLB

Houston Astros
3 :  8
Seattle Mariners
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 17, 2026 - MLB

Houston Astros
0 :  8
Texas Rangers

May 16, 2026 - MLB

Houston Astros
4 :  1
Texas Rangers

May 15, 2026 - MLB

Houston Astros
2 :  0
Texas Rangers

May 14, 2026 - MLB

Houston Astros
3 :  8
Seattle Mariners

May 13, 2026 - MLB

Houston Astros
4 :  3
Seattle Mariners

May 12, 2026 - MLB

Houston Astros
2 :  10
Seattle Mariners
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 19, 2026 - MLB

Minnesota Twins
1 :  2
Houston Astros

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

May 10, 2026 - MLB

Cincinnati Reds
5 :  0
Houston Astros

May 9, 2026 - MLB

Cincinnati Reds
3 :  1
Houston Astros

May 8, 2026 - MLB

Cincinnati Reds
0 :  10
Houston Astros

May 3, 2026 - MLB

Boston Red Sox
1 :  3
Houston Astros

Minnesota Twins against Houston Astros : Head to Head (H2H)

Minnesota Twins

50 %

Houston Astros

50 %

May 19, 2026 - MLB

Minnesota Twins
1 :  2
Houston Astros

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

Apr 5, 2025 - MLB

Minnesota Twins
6 :  1
Houston Astros

Apr 3, 2025 - MLB

Minnesota Twins
2 :  5
Houston Astros

Jul 6, 2024 - MLB

Minnesota Twins
9 :  3
Houston Astros

Jun 1, 2024 - MLB

Houston Astros
5 :  2
Minnesota Twins
Minnesota Twins vs Houston Astros Picks

Minnesota Twins - Houston Astros Key Points

  1. Mike Burrows has an ERA of 5.72 this season
  2. Mike Burrows has an ERA of 4.44 on the road this season
  3. Joe Ryan has an ERA of 3.20 this season
  4. Joe Ryan has an ERA of 2.31 at home this season
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Our Minnesota Twins vs Houston Astros Prediction

The Twins are the clear favorite in this game; however, they still look to be the best betting option. This goes back to the home/away splits between the starting pitchers. In four away starts this season, Burrows has allowed 12 earned runs across 24.1 innings.

As for Ryan, he has made five home starts, having allowed eight runs (six earned) over 23.1 innings. On top of the advantage the Twins have in starting pitching, they are also ranked 8th in runs scored, compared to the Astros, who rank 11th.

Because of this and the lack of consistency shown by Houston this season, our Minnesota Twins vs Houston Astros prediction is: Minnesota Twins ML.

Prediction:

 

Minnesota Twins ML

-156
$150 offered for betting!

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