Minnesota Twins vs Houston Astros Prediction & Picks - MLB

USA - MLB

Minnesota Twins
5/19/26 19:40
Houston Astros

Prediction:

 

Twins -1.5

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 by Travis Pulver | in MLB Picks

The Minnesota Twins (22-26, 14-13 Home) will try to make it three in a row at home today when they host the Houston Astros in Game Two of a three-game series. Game time is set for 7:40 p.m. EST at Target Field in Minneapolis, MN, with coverage provided by MLB.TV.

It wasn’t much of a challenge for the Twins in Game 1 as they got out to a 6-0 lead before the Astros were able to get on the board. Houston threatened to make the game interesting with three runs in the top of the seventh, but couldn’t get a hit in the eighth or ninth innings.

Zebby Matthews is scheduled to make just his second start of the season for the Twins today. he made his first against Miami last Thursday, pitching seven shutout innings and allowing just four hits.  Houston will hope for the best from Lance McCullers Jr. McCullers Jr. is 2-3 in eight starts with a 6.86 ERA and a 1.53 WHIP.  He has pitched better on the road despite his 7.53 ERA, going 1-0 in three starts while holding opponents to a .231 OBA. One of the seven home runs he has allowed came on the road.


 

Minnesota Twins vs Houston Astros Form

Table

Teams Pts P W L
12 Houston Astros
0.504 119 60 59
16 Minnesota Twins
0.492 120 59 61

Minnesota Twins and Houston Astros Latest Matches

Minnesota Twins
Minnesota Twins Latest matches
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

May 17, 2026 - MLB

Minnesota Twins
5 :  4
Milwaukee Brewers

May 16, 2026 - MLB

Minnesota Twins
1 :  2
Milwaukee Brewers

May 15, 2026 - MLB

Minnesota Twins
2 :  3
Milwaukee Brewers

May 14, 2026 - MLB

Minnesota Twins
9 :  1
Miami Marlins

May 13, 2026 - MLB

Minnesota Twins
5 :  9
Miami Marlins
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

May 17, 2026 - MLB

Minnesota Twins
5 :  4
Milwaukee Brewers

May 16, 2026 - MLB

Minnesota Twins
1 :  2
Milwaukee Brewers

May 15, 2026 - MLB

Minnesota Twins
2 :  3
Milwaukee Brewers

May 14, 2026 - MLB

Minnesota Twins
9 :  1
Miami Marlins

May 13, 2026 - MLB

Minnesota Twins
5 :  9
Miami Marlins
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 10, 2026 - MLB

Cleveland Guardians
4 :  5
Minnesota Twins

May 9, 2026 - MLB

Cleveland Guardians
1 :  2
Minnesota Twins

May 8, 2026 - MLB

Cleveland Guardians
6 :  4
Minnesota Twins

May 7, 2026 - MLB

Washington Nationals
7 :  5
Minnesota Twins

May 6, 2026 - MLB

Washington Nationals
15 :  2
Minnesota Twins

May 5, 2026 - MLB

Washington Nationals
3 :  11
Minnesota Twins
Houston Astros
Houston Astros Latest matches
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

May 17, 2026 - MLB

Houston Astros
0 :  8
Texas Rangers

May 16, 2026 - MLB

Houston Astros
4 :  1
Texas Rangers

May 15, 2026 - MLB

Houston Astros
2 :  0
Texas Rangers

May 14, 2026 - MLB

Houston Astros
3 :  8
Seattle Mariners

May 13, 2026 - MLB

Houston Astros
4 :  3
Seattle Mariners
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 17, 2026 - MLB

Houston Astros
0 :  8
Texas Rangers

May 16, 2026 - MLB

Houston Astros
4 :  1
Texas Rangers

May 15, 2026 - MLB

Houston Astros
2 :  0
Texas Rangers

May 14, 2026 - MLB

Houston Astros
3 :  8
Seattle Mariners

May 13, 2026 - MLB

Houston Astros
4 :  3
Seattle Mariners

May 12, 2026 - MLB

Houston Astros
2 :  10
Seattle Mariners
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

May 10, 2026 - MLB

Cincinnati Reds
5 :  0
Houston Astros

May 9, 2026 - MLB

Cincinnati Reds
3 :  1
Houston Astros

May 8, 2026 - MLB

Cincinnati Reds
0 :  10
Houston Astros

May 3, 2026 - MLB

Boston Red Sox
1 :  3
Houston Astros

May 2, 2026 - MLB

Boston Red Sox
3 :  6
Houston Astros

Minnesota Twins against Houston Astros : Head to Head (H2H)

Minnesota Twins

50 %

Houston Astros

50 %

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

Apr 5, 2025 - MLB

Minnesota Twins
6 :  1
Houston Astros

Apr 3, 2025 - MLB

Minnesota Twins
2 :  5
Houston Astros

Jul 6, 2024 - MLB

Minnesota Twins
9 :  3
Houston Astros

Jun 1, 2024 - MLB

Houston Astros
5 :  2
Minnesota Twins

Oct 10, 2023 - MLB

Minnesota Twins
1 :  9
Houston Astros
Minnesota Twins vs Houston Astros Picks

Minnesota Twins - Houston Astros Key Points

  1. Houston leads the all-time series vs. Minnesota 56-45.
  2. Houston is 19-30 ATS (run line); Minnesota is 26-22.
  3. The OVER is 28-18-3 for Houston and 27-17-4 for Minnesota.
  4. Betting Public: 88% of run line tickets and 98% of the handle are on the Twins.

Our Minnesota Twins vs Houston Astros Prediction

This has just been an awful year for Houston so far. Their lineup has hit well at times, but their pitching has just been horrible. Injuries have hampered the rotation, but that doesn’t excuse the bullpen having the highest ERA in baseball (5.82). So, even if the Twins light up McCullers Jr., the bullpen will likely not be any better. If the Zebby Matthews from 2025 shows up (5.56 ERA), Houston might have an outside chance of making this one competitive. But even if that version appears, the Astros' lineup is hitting only .207 over the last week.

Our Houston vs. Minnesota Pick: Twins -1.5

Prediction:

 

Twins -1.5

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