Minnesota Twins vs Houston Astros Prediction & Picks - MLB

Prediction published on 4/5/25, 10:31 AM  by Carlos Zabala | Modified on 2/16/26 at 4:26 PM in MLB Picks

The Astros and Twins rested on Friday and will resume the series on Saturday at Target Field. It's been anything but an ideal start for the Twins, who have the third-worst career ERA and third-worst AVG in MLB, as well as the worst OBP at .240.

Bailey Ober will start Game 2 for the Twins. He had an excellent spring training but a terrible start in his first official game, where he was battered by the Cardinals, who allowed eight earned runs, eight hits, and three walks. Spencer Arrighetti, on the other hand, had a solid performance against the Mets in Houston, allowing only one run, and will start for the Astros.

The Astros' pitching has the best BAA in MLB at .164 and the third-best K/9 at 11.00.

Thursday's game ended 5-2 in favor of the Astros, with Peña and Walker contributing back-to-back home runs. Surprisingly, Altuve struck out five times in a game for the first time in 15 MLB seasons.