Cleveland Guardians vs Houston Astros Prediction & Picks - MLB

Prediction published on 4/21/26, 2:51 PM  by Travis Pulver | Modified on 4/22/26 at 11:38 AM in MLB Picks

The Houston Astros (9-15, 2-9 Away) will try to make it two in a row on the road for the first time this season when they face the Guardians on Tuesday, April 21, at Progressive Field in Cleveland, OH. First Pitch is scheduled for 6:10 p.m. EST with coverage provided by MLB.TV.

For Houston, the struggle has been all too real. Prior to Monday’s 9-2 win over the Guardians in Cleveland, the Astros had gone 1-9 in road games. The win also brought their current losing streak to an end at four in a row. If they are going to make it two in a row, they’ll need something they haven’t seen much of all season— quality pitching out of the bullpen.

The ERA for the 'pen has been 6.0+, but just recently dropped back below 6.00 to 5.66, the highest for a bullpen in baseball to date and the only one over 5.00. Ryan Weiss is set to start the day on the mound for Houston. He has a 6.75 ERA, and opponents have been hitting .254 with a 2.05 WHIP.

Cleveland is scheduled to start Parker Messick. Messick has had a solid season to date, having gone 3-0 in four starts with a 1.05 ERA and a .78 WHIP.