Chicago Cubs vs Houston Astros Prediction & Picks - MLB

USA - MLB

Chicago Cubs
5/23/26 14:20
Houston Astros

Prediction:

 

Under 8.5 runs

-167
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 by Stephen Abiola | in MLB Picks

Chicago Cubs (29-22) and Houston Astros (21-31) will meet for the second time in this three-game series on Saturday evening at Wrigley Field. The Cubs opened this series with a 2-4 defeat on Friday night, dropping to 2-10 in their last 12 assignments. Just two weeks ago, the Cubs were basking in their second 10-game winning streak this season. They now find themselves stuttering at home, where they’ve dropped four matches in a row.

As for the Astros, the Friday night win was more than just any other victory this season. The Stros had not won at Wrigley Field for the last 13 years. Despite the win, the Astros are still struggling to keep their campaign afloat, sitting in fourth place in the AL West with a .404 win percentage. Their offense has struggled to impress lately, having failed to score more than four runs in their last 13 matches. Chicago’s pitching performance has been commendable, though.

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Chicago Cubs vs Houston Astros Form

Table

Teams Pts P W L
7 Chicago Cubs
0.542 83 45 38
18 Houston Astros
0.482 85 41 44

Chicago Cubs and Houston Astros Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

May 22, 2026 - MLB

Chicago Cubs
2 :  4
Houston Astros

May 20, 2026 - MLB

Chicago Cubs
0 :  5
Milwaukee Brewers

May 19, 2026 - MLB

Chicago Cubs
2 :  5
Milwaukee Brewers

May 18, 2026 - MLB

Chicago Cubs
3 :  9
Milwaukee Brewers

May 17, 2026 - MLB

Chicago White Sox
9 :  8
Chicago Cubs

May 16, 2026 - MLB

Chicago White Sox
8 :  3
Chicago Cubs
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 22, 2026 - MLB

Chicago Cubs
2 :  4
Houston Astros

May 20, 2026 - MLB

Chicago Cubs
0 :  5
Milwaukee Brewers

May 19, 2026 - MLB

Chicago Cubs
2 :  5
Milwaukee Brewers

May 18, 2026 - MLB

Chicago Cubs
3 :  9
Milwaukee Brewers

May 7, 2026 - MLB

Chicago Cubs
8 :  3
Cincinnati Reds

May 6, 2026 - MLB

Chicago Cubs
7 :  6
Cincinnati Reds
L L W W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 17, 2026 - MLB

Chicago White Sox
9 :  8
Chicago Cubs

May 16, 2026 - MLB

Chicago White Sox
8 :  3
Chicago Cubs

May 15, 2026 - MLB

Chicago White Sox
5 :  10
Chicago Cubs

May 14, 2026 - MLB

Atlanta Braves
0 :  2
Chicago Cubs

May 13, 2026 - MLB

Atlanta Braves
4 :  1
Chicago Cubs

May 12, 2026 - MLB

Atlanta Braves
5 :  2
Chicago Cubs
Houston Astros
Houston Astros Latest matches
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 22, 2026 - MLB

Chicago Cubs
2 :  4
Houston Astros

May 20, 2026 - MLB

Minnesota Twins
4 :  1
Houston Astros

May 19, 2026 - MLB

Minnesota Twins
1 :  2
Houston Astros

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

May 17, 2026 - MLB

Houston Astros
0 :  8
Texas Rangers

May 16, 2026 - MLB

Houston Astros
4 :  1
Texas Rangers
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 17, 2026 - MLB

Houston Astros
0 :  8
Texas Rangers

May 16, 2026 - MLB

Houston Astros
4 :  1
Texas Rangers

May 15, 2026 - MLB

Houston Astros
2 :  0
Texas Rangers

May 14, 2026 - MLB

Houston Astros
3 :  8
Seattle Mariners

May 13, 2026 - MLB

Houston Astros
4 :  3
Seattle Mariners

May 12, 2026 - MLB

Houston Astros
2 :  10
Seattle Mariners
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 22, 2026 - MLB

Chicago Cubs
2 :  4
Houston Astros

May 20, 2026 - MLB

Minnesota Twins
4 :  1
Houston Astros

May 19, 2026 - MLB

Minnesota Twins
1 :  2
Houston Astros

May 18, 2026 - MLB

Minnesota Twins
6 :  3
Houston Astros

May 10, 2026 - MLB

Cincinnati Reds
5 :  0
Houston Astros

May 9, 2026 - MLB

Cincinnati Reds
3 :  1
Houston Astros

Chicago Cubs against Houston Astros : Head to Head (H2H)

Chicago Cubs

50 %

Houston Astros

50 %

May 22, 2026 - MLB

Chicago Cubs
2 :  4
Houston Astros

Jun 29, 2025 - MLB

Houston Astros
2 :  0
Chicago Cubs

Jun 28, 2025 - MLB

Houston Astros
3 :  12
Chicago Cubs

Jun 27, 2025 - MLB

Houston Astros
7 :  4
Chicago Cubs

Apr 24, 2024 - MLB

Chicago Cubs
4 :  3
Houston Astros

Apr 23, 2024 - MLB

Chicago Cubs
7 :  2
Houston Astros

Chicago Cubs - Houston Astros Key Points

  1. Chicago Cubs (29-22) and Houston Astros (21-31) will meet for the second time in this three-game series on Saturday evening at Wrigley Field. The Cubs opened this series with a 2-4 defeat on Friday night, dropping to 2-10 in their last 12 assignments. Just two weeks ago, the Cubs were basking in their second 10-game winning streak this season. They now find themselves stuttering at home, where they’ve dropped four matches in a row. As for the Astros, the Friday night win was more than just any other victory this season. The Stros had not won at Wrigley Field for the last 13 years. Despite the win, the Astros are still struggling to keep their campaign afloat, sitting in fourth place in the AL West with a .404 win percentage. Their offense has struggled to impress lately, having failed to score more than four runs in their last 13 matches. Chicago’s pitching performance has been commendable, though.
  2. The total runs went under in three of the last four Chicago Cubs matches.
  3. The total runs went under in five of the last seven Chicago Cubs vs Houston Astros matches.
  4. The total runs went under 8.5 in six of the last seven Houston Astros matches.
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Our Chicago Cubs vs Houston Astros Prediction

Chicago Cubs are favored at -160 odds to bounce back tonight. The H2H statistics are on their side, having gone 3-1 in their last four clashes. They also have a respectable 18-9 record at home this season, whereas the Stros have gone 9-17 on the road. However, we’ll go with the total runs to stay under 8.5 in this contest due to the low-scoring nature of this fixture. Both teams have struggled on offense lately, with the Cubs scoring an average of 3.0 runs in their last six games. The Astros, on the other hand, have averaged 2.33 runs in their last six games. The Cubs will start Colin Rea (4-2, 5.00 ERA) while the Astros will play Kai-Wei Teng (2-3, 2.60 ERA). Chicago should edge it tonight. 

Our prediction for Chicago Cubs vs Houston Astros: Under 8.5 runs.

Prediction:

 

Under 8.5 runs

-167
$200 offered for betting!

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Chicago Cubs vs Houston Astros Picks