Baltimore Orioles vs Houston Astros Prediction & Picks - MLB

USA - MLB

Baltimore Orioles
4/29/26 18:35
Houston Astros

Prediction:

 

Astros ML

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 by Travis Pulver | in MLB Picks

The Orioles (14-15, 8-8 Home) will try to get back to .500 today when they host the Houston Astros (11-19, 3-11 Away) in Game Two of a three-game series at Oriole Park at Camden Yards in Baltimore, MD. Fans can follow the action on MLB.TV once the game gets underway at 6:35 p.m. EST.

Boston came into the series two games below .500 (13-15) after dropping two to the Boston Red Sox over the weekend. But they got back on track in Game One of this series on Tuesday with a 5-3 win over the visiting Astros. The Orioles took the lead with two runs in the bottom of the first and essentially never looked back. They stretched the lead out to 5-1 with a run in the seventh. Houston tacked on a pair in the eighth to make the final 5-3.

Baltimore will hand the ball to Chris Bassitt to start the day. Bassitt is 1-3 in five starts with a 6.75 ERA and 2.06 WHIP. He has had some issues with the Houston lineup in the past. In 125 at-bats, the Astros lineup has hit .288 against him with nine home runs and only 18 strikeouts.

As for Houston, the Astros will give Peter Lambert the ball. Lambert is 1-1 in two starts with a 3.27 ERA and a 1.27 WHIP. He blanked the Guardians in his last outing, throwing six innings of three-hit, shutout ball.

Baltimore Orioles vs Houston Astros Form

Table

Teams Pts P W L
18 Houston Astros
0.482 85 41 44
22 Baltimore Orioles
0.464 84 39 45

Baltimore Orioles and Houston Astros Latest Matches

Baltimore Orioles
Baltimore Orioles Latest matches
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 28, 2026 - MLB

Baltimore Orioles
5 :  3
Houston Astros

Apr 26, 2026 - MLB

Baltimore Orioles
3 :  5
Boston Red Sox

Apr 25, 2026 - MLB

Baltimore Orioles
1 :  17
Boston Red Sox

Apr 24, 2026 - MLB

Baltimore Orioles
10 :  3
Boston Red Sox

Apr 22, 2026 - MLB

Kansas City Royals
6 :  8
Baltimore Orioles

Apr 21, 2026 - MLB

Kansas City Royals
6 :  5
Baltimore Orioles
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 28, 2026 - MLB

Baltimore Orioles
5 :  3
Houston Astros

Apr 26, 2026 - MLB

Baltimore Orioles
3 :  5
Boston Red Sox

Apr 25, 2026 - MLB

Baltimore Orioles
1 :  17
Boston Red Sox

Apr 24, 2026 - MLB

Baltimore Orioles
10 :  3
Boston Red Sox

Apr 15, 2026 - MLB

Baltimore Orioles
5 :  8
Arizona Diamondbacks

Apr 14, 2026 - MLB

Baltimore Orioles
3 :  4
Arizona Diamondbacks
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 22, 2026 - MLB

Kansas City Royals
6 :  8
Baltimore Orioles

Apr 21, 2026 - MLB

Kansas City Royals
6 :  5
Baltimore Orioles

Apr 20, 2026 - MLB

Kansas City Royals
5 :  7
Baltimore Orioles

Apr 19, 2026 - MLB

Cleveland Guardians
8 :  4
Baltimore Orioles

Apr 18, 2026 - MLB

Cleveland Guardians
4 :  2
Baltimore Orioles

Apr 17, 2026 - MLB

Cleveland Guardians
4 :  6
Baltimore Orioles
Houston Astros
Houston Astros Latest matches
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 28, 2026 - MLB

Baltimore Orioles
5 :  3
Houston Astros

Apr 26, 2026 - MLB

Houston Astros
7 :  4
New York Yankees

Apr 25, 2026 - MLB

Houston Astros
3 :  8
New York Yankees

Apr 24, 2026 - MLB

Houston Astros
4 :  12
New York Yankees

Apr 22, 2026 - MLB

Cleveland Guardians
0 :  2
Houston Astros

Apr 21, 2026 - MLB

Cleveland Guardians
8 :  5
Houston Astros
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 26, 2026 - MLB

Houston Astros
7 :  4
New York Yankees

Apr 25, 2026 - MLB

Houston Astros
3 :  8
New York Yankees

Apr 24, 2026 - MLB

Houston Astros
4 :  12
New York Yankees

Apr 19, 2026 - MLB

Houston Astros
5 :  7
St. Louis Cardinals

Apr 18, 2026 - MLB

Houston Astros
5 :  7
St. Louis Cardinals

Apr 17, 2026 - MLB

Houston Astros
4 :  9
St. Louis Cardinals
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 28, 2026 - MLB

Baltimore Orioles
5 :  3
Houston Astros

Apr 22, 2026 - MLB

Cleveland Guardians
0 :  2
Houston Astros

Apr 21, 2026 - MLB

Cleveland Guardians
8 :  5
Houston Astros

Apr 20, 2026 - MLB

Cleveland Guardians
2 :  9
Houston Astros

Apr 13, 2026 - MLB

Seattle Mariners
6 :  2
Houston Astros

Apr 12, 2026 - MLB

Seattle Mariners
6 :  1
Houston Astros

Baltimore Orioles against Houston Astros : Head to Head (H2H)

Baltimore Orioles

33 %

Houston Astros

67 %

Apr 28, 2026 - MLB

Baltimore Orioles
5 :  3
Houston Astros

Mar 10, 2026 - MLB Spring Training

Houston Astros
7 :  6
Baltimore Orioles

Mar 4, 2026 - MLB Spring Training

Baltimore Orioles
2 :  4
Houston Astros

Aug 24, 2025 - MLB

Baltimore Orioles
3 :  2
Houston Astros

Aug 23, 2025 - MLB

Baltimore Orioles
8 :  9
Houston Astros

Aug 22, 2025 - MLB

Baltimore Orioles
7 :  10
Houston Astros

Baltimore Orioles - Houston Astros Key Points

  1. Houston holds the all-time series lead vs. Baltimore, 51-38.
  2. Baltimore is 13-16 ATS (run line) this season; Houston is 11-19.
  3. The OVER is 18-11 for the Orioles this season and 21-9 for Houston.
  4. Betting Public: 44% of moneyline tickets and 66% of the handle are on Houston.

Our Baltimore Orioles vs Houston Astros Prediction

Houston has been terrible on the road, but the Orioles haven’t exactly been dominant at home, so that may not matter. Baltimore has been hitting well over the last week (.299) and averaged just under 5 runs per game (four games). Houston hit .263 and averaged just under four runs a game. But Bassitt has struggled against the Astros, and with how he has been pitching, could do so again today. Peter Lambert has only made two appearances this season, but is coming off an excellent outing vs. Cleveland.

I don’t know if I trust these offenses to go over the total or cover, but I like Lambert to control the Baltimore lineup and lead Houston to a rare road win.

Our Houston vs. Baltimore Pick: Astros ML

Prediction:

 

Astros ML

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Baltimore Orioles vs Houston Astros Picks