Baltimore Orioles vs Houston Astros Prediction & Picks - MLB

USA - MLB

Baltimore Orioles
4/28/26 18:35
Houston Astros

Prediction:

 

Over 9.5 Runs

+100
$250 offered for betting!

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 by Lou Aguila | in MLB Picks

The Over 9.5 (+100) is shaping up to be a profitable option as the Baltimore Orioles and the Houston Astros, both pitching roughly 5.00 ERA this season, kick off their series on Tuesday.

Momentum: the Baltimore Orioles lost the final two games of their series against the Boston Red Sox, causing them to plunge below .500 again at 13-15.

The Houston Astros snapped a two-game slide with a 7-4 win over the New York Yankees in their series finale. The Astros are still seven games below .500 with an 11-18 record.

The Matchup: This is the first series between the American League rivals. Houston has won 10 of its last 15 meetings with Baltimore.

Hot on the Board: Caesars Sportsbook prices the skidding Houston at +118 moneyline and -170 with +1.5-run boost on the spread line. Baltimore, 2-3 in their last five games with the Astros, carries a -140 moneyline value and +143 on a 1.5-run handicap.

Up to $250 to bet on Baltimore Orioles - Houston Astros! 

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Baltimore Orioles vs Houston Astros Form

Table

Teams Pts P W L
21 Houston Astros
0.468 77 36 41
23 Baltimore Orioles
0.455 77 35 42

Baltimore Orioles and Houston Astros Latest Matches

Baltimore Orioles
Baltimore Orioles Latest matches
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 26, 2026 - MLB

Baltimore Orioles
3 :  5
Boston Red Sox

Apr 25, 2026 - MLB

Baltimore Orioles
1 :  17
Boston Red Sox

Apr 24, 2026 - MLB

Baltimore Orioles
10 :  3
Boston Red Sox

Apr 22, 2026 - MLB

Kansas City Royals
6 :  8
Baltimore Orioles

Apr 21, 2026 - MLB

Kansas City Royals
6 :  5
Baltimore Orioles

Apr 20, 2026 - MLB

Kansas City Royals
5 :  7
Baltimore Orioles
W L L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 26, 2026 - MLB

Baltimore Orioles
3 :  5
Boston Red Sox

Apr 25, 2026 - MLB

Baltimore Orioles
1 :  17
Boston Red Sox

Apr 24, 2026 - MLB

Baltimore Orioles
10 :  3
Boston Red Sox

Apr 15, 2026 - MLB

Baltimore Orioles
5 :  8
Arizona Diamondbacks

Apr 14, 2026 - MLB

Baltimore Orioles
3 :  4
Arizona Diamondbacks

Apr 13, 2026 - MLB

Baltimore Orioles
9 :  7
Arizona Diamondbacks
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 22, 2026 - MLB

Kansas City Royals
6 :  8
Baltimore Orioles

Apr 21, 2026 - MLB

Kansas City Royals
6 :  5
Baltimore Orioles

Apr 20, 2026 - MLB

Kansas City Royals
5 :  7
Baltimore Orioles

Apr 19, 2026 - MLB

Cleveland Guardians
8 :  4
Baltimore Orioles

Apr 18, 2026 - MLB

Cleveland Guardians
4 :  2
Baltimore Orioles

Apr 17, 2026 - MLB

Cleveland Guardians
4 :  6
Baltimore Orioles
Houston Astros
Houston Astros Latest matches
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 26, 2026 - MLB

Houston Astros
7 :  4
New York Yankees

Apr 25, 2026 - MLB

Houston Astros
3 :  8
New York Yankees

Apr 24, 2026 - MLB

Houston Astros
4 :  12
New York Yankees

Apr 22, 2026 - MLB

Cleveland Guardians
0 :  2
Houston Astros

Apr 21, 2026 - MLB

Cleveland Guardians
8 :  5
Houston Astros

Apr 20, 2026 - MLB

Cleveland Guardians
2 :  9
Houston Astros
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 26, 2026 - MLB

Houston Astros
7 :  4
New York Yankees

Apr 25, 2026 - MLB

Houston Astros
3 :  8
New York Yankees

Apr 24, 2026 - MLB

Houston Astros
4 :  12
New York Yankees

Apr 19, 2026 - MLB

Houston Astros
5 :  7
St. Louis Cardinals

Apr 18, 2026 - MLB

Houston Astros
5 :  7
St. Louis Cardinals

Apr 17, 2026 - MLB

Houston Astros
4 :  9
St. Louis Cardinals
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 22, 2026 - MLB

Cleveland Guardians
0 :  2
Houston Astros

Apr 21, 2026 - MLB

Cleveland Guardians
8 :  5
Houston Astros

Apr 20, 2026 - MLB

Cleveland Guardians
2 :  9
Houston Astros

Apr 13, 2026 - MLB

Seattle Mariners
6 :  2
Houston Astros

Apr 12, 2026 - MLB

Seattle Mariners
6 :  1
Houston Astros

Apr 11, 2026 - MLB

Seattle Mariners
8 :  7
Houston Astros

Baltimore Orioles against Houston Astros : Head to Head (H2H)

Baltimore Orioles

17 %

Houston Astros

83 %

Mar 10, 2026 - MLB Spring Training

Houston Astros
7 :  6
Baltimore Orioles

Mar 4, 2026 - MLB Spring Training

Baltimore Orioles
2 :  4
Houston Astros

Aug 24, 2025 - MLB

Baltimore Orioles
3 :  2
Houston Astros

Aug 23, 2025 - MLB

Baltimore Orioles
8 :  9
Houston Astros

Aug 22, 2025 - MLB

Baltimore Orioles
7 :  10
Houston Astros

Aug 21, 2025 - MLB

Baltimore Orioles
2 :  7
Houston Astros

Baltimore Orioles - Houston Astros Key Points

  1. The total has gone OVER in 5 of Baltimore's last 6 games against Houston.
  2. The total has gone OVER in 5 of Baltimore's last 6 games at home.
  3. The total has gone OVER in 8 of Houston's last 9 games.
  4. The total has gone OVER in 4 of Houston's last 5 games when playing on the road against Baltimore.
Up to $250 to bet on Baltimore Orioles - Houston Astros! 

Limited Offer. Currently at Caesars Sportsbook

Our Baltimore Orioles vs Houston Astros Prediction

Take Over 9.5 runs at +100 is an attractive pick for this series opener, considering that Baltimore and Houston are two of the worst pitching teams in the MLB this season.

The Orioles have posted a 4.43 ERA this season and a 6.70 ERA over the last five games. The Astros have registered a 5.97 ERA this season and a 6.14 ERA over their last five assignments.

Orioles starting pitcher Shane Baz has been atrocious on the mound, registering a 0-2 record with a 5.08 ERA. Kai-Wei Teng is a relief pitcher for the Astros, making his first start this season. Don’t expect him to have a major impact in this game because Houston could pull him out of the mound after just two innings as part of the tactic to give their relief pitchers more time on the mound while resting their starters.

This is going to be a back-and-forth series that will produce plenty of home runs, poor pitching and fielding, and high-scoring games.

Our betting prediction for the Houston Astros vs. the Baltimore Orioles: Over 9.5 Runs.

Prediction:

 

Over 9.5 Runs

+100
$250 offered for betting!

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Baltimore Orioles vs Houston Astros Picks