St. Louis Cardinals vs Detroit Tigers Prediction & Picks - MLB

Prediction published on 5/21/25, 9:49 AM  by Carlos Zabala | Modified on 5/21/25 at 4:00 PM in MLB Picks

In the first game of the Cardinals-Tigers series, Gray dominated Detroit's red-hot lineup for the home team. The game, which began as a pitching duel, ended 11-4. The next day, the Tigers brought in Skubal, and the current Cy Young's presence alone boosted the Tigers' odds until they closed around -180 in the pregame action.

In Game 2, Skubal dominated, scoring 4 shutouts in the first 4 innings, while also receiving offensive support from Carpenter and Greene with home runs. However, the Cardinals would have the better at-bats in each of their third at-bats against Skubal, temporarily tying the score at 4-4. Greene would again appear in the clutch for the Tigers, scoring a go-ahead double in the 9th inning. Reliever Will Vest pitched a scoreless inning and earned his 4th win of the season.

The Tigers and Cardinals will play the decisive game of the series early this afternoon at Busch Stadium. Andre Pallante is scheduled to pitch for the home team, putting together two strong outings on May 10 and 16.