Pittsburgh Pirates vs Colorado Rockies Prediction & Picks - MLB

Prediction published on 5/13/26, 3:21 PM  by Carlos Zabala | Modified on 5/18/26 at 4:08 PM in MLB Picks

Once again, the Pirates' numbers are showing a stark contrast between their on-road performance and their home games at Coors Field. They're averaging 3.7 runs on the road and only managed one in their series opener loss to the Pirates at PNC Park.

The first game of the series was a dominant performance by Cy Young Award winner Paul Skenes, who pitched eight innings, carried the no-hitter into the seventh, earned the win, struck out 10 Rockies, and issued no walks. The Pirates won the series opener as favorites, with odds of -290 at the sportsbooks before the game. This marks the fifth consecutive time Pittsburgh has defeated Colorado, and it has always been favored with odds of -150 or better.

On Wednesday, it's the turn of another reliable Pirates arm, Mitch Keller, who is putting up impressive numbers: a 2.87 ERA in 47 innings pitched and a 4-1 record. He wants to continue where Skenes left off, and he's expected to strengthen his position on the mound. In two of his last four starts, he pitched seven innings, and in the other two, five or more.