Colorado Buffaloes vs Houston Cougars Prediction & Picks - NCAA

USA - NCAA

Colorado Buffaloes
9/12/25 19:30
Houston Cougars

Prediction:

 

Houston Cougars ML

-218
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 by Matt Lowrimore in NCAA Picks

Week 3 of the college football season will feature several games on Friday night, one of which will see the Colorado Buffaloes take on the Houston Cougars in a Big 12 matchup. Let's take a look at the match statistics and predictions for this game between the Buffaloes and Cougars.

Colorado enters this game with a record of 1-1, and this will be their first Big 12 game this season. The Buffaloes most recently beat the Delaware Blue Hens in Week 2 by a score of 31-7. Colorado's offense posted a total of 398 yards, while its defense allowed 396 yards. Quarterback Ryan Staub threw for 157 yards and two touchdowns, while running back Simeon Price led the team in rushing with 55 yards.

As for Houston, they enter this game with a record of 2-0, and this will also be their first game in the Big 12. The Cougars most recently beat the Rice Owls in Week 2 by a score of 35-9. Houston's offense posted a total of 395 yards, while its defense allowed 205 yards. Quarterback Conner Weigman threw for 188 yards and one touchdown, while running back Dean Conners led the team in rushing with 132 yards and two touchdowns.

Colorado Buffaloes vs Houston Cougars Form

Table

Teams Pts P W D L
11
Houston Cougars
Houston Cougars
0 0 0 0 0
12
Colorado Buffaloes
Colorado Buffaloes
0 0 0 0 0

Colorado Buffaloes and Houston Cougars Latest Matches

Colorado Buffaloes
Colorado Buffaloes Latest matches
W L W L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 6, 2025 - NCAA

Delaware Blue Hens
7 :  31
Colorado Buffaloes

Aug 29, 2025 - NCAA

Georgia Tech Yellow Jackets
27 :  20
Colorado Buffaloes

Dec 28, 2024 - NCAA Division I, FBS, Playoffs

BYU Cougars
36 :  14
Colorado Buffaloes

Nov 29, 2024 - NCAA

Oklahoma State Cowboys
0 :  52
Colorado Buffaloes

Nov 23, 2024 - NCAA

Colorado Buffaloes
21 :  37
Kansas Jayhawks

Nov 16, 2024 - NCAA

Utah Utes
24 :  49
Colorado Buffaloes
W W W L L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 6, 2025 - NCAA

Delaware Blue Hens
7 :  31
Colorado Buffaloes

Aug 29, 2025 - NCAA

Georgia Tech Yellow Jackets
27 :  20
Colorado Buffaloes

Dec 28, 2024 - NCAA Division I, FBS, Playoffs

BYU Cougars
36 :  14
Colorado Buffaloes

Nov 29, 2024 - NCAA

Oklahoma State Cowboys
0 :  52
Colorado Buffaloes

Nov 16, 2024 - NCAA

Utah Utes
24 :  49
Colorado Buffaloes

Oct 26, 2024 - NCAA

Cincinnati Bearcats
23 :  34
Colorado Buffaloes
L W W W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 23, 2024 - NCAA

Colorado Buffaloes
21 :  37
Kansas Jayhawks

Nov 9, 2024 - NCAA

Colorado Buffaloes
41 :  27
Texas Tech Red Raiders

Oct 19, 2024 - NCAA

Colorado Buffaloes
34 :  7
Arizona Wildcats

Sep 28, 2024 - NCAA

Colorado Buffaloes
48 :  21
UCF Knights

Sep 14, 2024 - NCAA

Colorado Buffaloes
28 :  9
Colorado State Rams

Sep 7, 2024 - NCAA

Colorado Buffaloes
10 :  28
Nebraska Cornhuskers
Houston Cougars
Houston Cougars Latest matches
W L L L W W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 6, 2025 - NCAA

Houston Cougars
35 :  9
Rice Owls

Aug 28, 2025 - NCAA

Stephen F. Austin Lumberjacks
0 :  27
Houston Cougars

Nov 30, 2024 - NCAA

Houston Cougars
18 :  30
BYU Cougars

Nov 23, 2024 - NCAA

Baylor Bears
20 :  10
Houston Cougars

Nov 15, 2024 - NCAA

Houston Cougars
3 :  27
Arizona Wildcats

Nov 2, 2024 - NCAA

Kansas State Wildcats
19 :  24
Houston Cougars
W L W W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Aug 28, 2025 - NCAA

Stephen F. Austin Lumberjacks
0 :  27
Houston Cougars

Nov 23, 2024 - NCAA

Baylor Bears
20 :  10
Houston Cougars

Nov 2, 2024 - NCAA

Kansas State Wildcats
19 :  24
Houston Cougars

Oct 26, 2024 - NCAA

Utah Utes
14 :  17
Houston Cougars

Sep 28, 2024 - NCAA

Iowa State Cyclones
20 :  0
Houston Cougars

Sep 14, 2024 - NCAA

Rice Owls
7 :  33
Houston Cougars
L W L L L W
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 6, 2025 - NCAA

Houston Cougars
35 :  9
Rice Owls

Nov 30, 2024 - NCAA

Houston Cougars
18 :  30
BYU Cougars

Nov 15, 2024 - NCAA

Houston Cougars
3 :  27
Arizona Wildcats

Oct 19, 2024 - NCAA

Houston Cougars
14 :  42
Kansas Jayhawks

Oct 4, 2024 - NCAA

Houston Cougars
30 :  19
TCU Horned Frogs

Sep 21, 2024 - NCAA

Houston Cougars
0 :  34
Cincinnati Bearcats

Colorado Buffaloes - Houston Cougars Key Points

  1. Houston is 2-0 ATS this season
  2. Colorado is 1-1 ATS this season
  3. Houston is allowing 4.5 points per game this season
  4. Colorado is allowing an average of 429.5 total yards per game this season

Our Colorado Buffaloes vs Houston Cougars Prediction

Despite winning their Week 2 game against an inferior opponent, the Colorado defense still looks to be a liability. They only allowed seven points in Week 2, but still managed to allow nearly 400 total yards. The Buffaloes' rushing defense did a much better job than in Week 1, where they allowed 320 yards on the ground to Georgia Tech, but their passing defense allowed 312 yards to Delaware.

 As for Houston, their defense has been elite so far this season, having allowed an average of 4.5 points per game through the first two weeks. Additionally, Houston has been balanced offensively this season, plus they will be playing at home in this game. For that reason, our Colorado Buffaloes vs Houston Cougars prediction is: Houston Cougars ML.

Prediction:

 

Houston Cougars ML

-218
$400+ offered for betting!

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Colorado Buffaloes vs Houston Cougars Picks