San Diego Padres vs Cleveland Guardians Prediction & Picks - MLB
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by Lou Aguila | in MLB Picks
The San Diego head into Wednesday’s series finale with the Cleveland Guardians at Petco Park, looking to keep their immaculate record intact.
The Padres have put on an impeccable start to their 2025 MLB campaign with a scatheless 6-0 slate. San Diego possesses one of the most formidable batting lineups in baseball headed by Francisco Tatis Jr., Manny Machado and Jackson Merrill. However, the Padres have also imposed their will on the mound, where they posted a 1.80 ERA, 0.96 WHIP and .168 BAA – all in the top 5 in their respective categories.
The Guardians have no idea what hit them in the past two games. Cleveland entered the series with the Padres with a 2-1 record and had scored a total of 16 runs in the season-opening series against the Kansas City Royals. Against San Diego, the Guardians have only scored two runs so far and ended up scoreless 0-7 in Game 2.
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San Diego Padres vs Cleveland Guardians Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
7
|
0.556 | 162 | 90 | 72 |
|
10
|
0.543 | 162 | 88 | 74 |
San Diego Padres and Cleveland Guardians Latest Matches
5/6 (83%)
1/6 (17%)
Mar 31, 2025 - MLB
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Oct 11, 2024 - MLB
5/6 (83%)
1/6 (17%)
Mar 31, 2025 - MLB
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Oct 9, 2024 - MLB
2/6 (33%)
4/6 (67%)
Oct 11, 2024 - MLB
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Sep 28, 2024 - MLB
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Sep 25, 2024 - MLB
2/6 (33%)
4/6 (67%)
Mar 31, 2025 - MLB
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3/6 (50%)
3/6 (50%)
Oct 19, 2024 - MLB
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Oct 5, 2024 - MLB
2/6 (33%)
4/6 (67%)
Mar 31, 2025 - MLB
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San Diego Padres against Cleveland Guardians : Head to Head (H2H)
60 %
40 %
Mar 31, 2025 - MLB
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San Diego Padres - Cleveland Guardians Key Points
- San Diego are 5-0 SU in their last 5 games at home.
- San Diego are 4-1 SU in their last 5 games when playing at home against Cleveland.
- Cleveland are 2-5 SU in their last 7 games.
- Cleveland are 1-4 SU in their last 5 games against San Diego.
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Our San Diego Padres vs Cleveland Guardians Prediction
The Padres are sending Dylan Cease to the mound on Wednesday. Cease is 2-1 in his last three faceoffs with the Guardians, whom he blanked for seven innings with 10 strikeouts in San Diego’s 7-0 win last July 20, 2024. He will duel against Edward Lively, who is 4-1 in his last five starts but allowed two earned runs in a 1-2 loss to San Diego on July 21. In what will likely be a low-scoring match, I still expect the Padres to grind out a close win behind their terrific bullpen that has only allowed a 0.38 ERA this season. San Diego has also been superior at home with a 5-0 record, covering the spread four times. Our betting prediction for San Diego Padres vs. Cleveland Guardians: Padres will cover -1.5 runs.
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
