Toronto Blue Jays vs Cleveland Guardians Prediction & Picks - MLB

USA - MLB

Toronto Blue Jays
4/25/26 15:07
Cleveland Guardians

Prediction:

 

The Guardians will win

+122
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 by Lou Aguila | in MLB Picks

The Cleveland Guardians target back-to-back road wins over the Toronto Blue Jays in Game 2 of their series on Saturday.

Momentum: The Cleveland Guardians have won 3 of their last five in an alternating pattern to improve their record to 15-12, first in the American League Central. After winning three in a row, the Toronto Blue Jays suffered back-to-back setbacks against the LA Angels 3-7 in their series finale and the Guardians 6-8 in the series opener on Friday.

The Matchup: This is an interleague confrontation, which means this is the only time the Guardians and the Jays play each other in a series this regular season.

Starting Pitchers: Guardians LHP Joey Cantillo 1-0 (3.20 ERA) vs. Blue Jays RHP Kevin Gausmann (1-1, 2.54 ERA).

Hot on the Board: The Guardians, who are 7-3 in their last 10 meetings against the Blue Jays, are priced at +122 moneyline and -170 on the +1.5 run line. The Blue Jays, 6-14 in their last 20 games, are the favorites -145 moneyline and +143 to cover -1.5 runs.

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Toronto Blue Jays vs Cleveland Guardians Form

Table

Teams Pts P W L
9 Cleveland Guardians
0.529 70 37 33
19 Toronto Blue Jays
0.478 69 33 36

Toronto Blue Jays and Cleveland Guardians Latest Matches

Toronto Blue Jays
Toronto Blue Jays Latest matches
L W W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 24, 2026 - MLB

Toronto Blue Jays
6 :  8
Cleveland Guardians

Apr 22, 2026 - MLB

Los Angeles Angels
7 :  3
Toronto Blue Jays

Apr 21, 2026 - MLB

Los Angeles Angels
2 :  4
Toronto Blue Jays

Apr 20, 2026 - MLB

Los Angeles Angels
2 :  5
Toronto Blue Jays

Apr 19, 2026 - MLB

Arizona Diamondbacks
4 :  10
Toronto Blue Jays

Apr 18, 2026 - MLB

Arizona Diamondbacks
6 :  2
Toronto Blue Jays
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 24, 2026 - MLB

Toronto Blue Jays
6 :  8
Cleveland Guardians

Apr 12, 2026 - MLB

Toronto Blue Jays
2 :  8
Minnesota Twins

Apr 11, 2026 - MLB

Toronto Blue Jays
4 :  7
Minnesota Twins

Apr 10, 2026 - MLB

Toronto Blue Jays
10 :  4
Minnesota Twins

Apr 8, 2026 - MLB

Toronto Blue Jays
4 :  3
Los Angeles Dodgers

Apr 7, 2026 - MLB

Toronto Blue Jays
1 :  4
Los Angeles Dodgers
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 22, 2026 - MLB

Los Angeles Angels
7 :  3
Toronto Blue Jays

Apr 21, 2026 - MLB

Los Angeles Angels
2 :  4
Toronto Blue Jays

Apr 20, 2026 - MLB

Los Angeles Angels
2 :  5
Toronto Blue Jays

Apr 19, 2026 - MLB

Arizona Diamondbacks
4 :  10
Toronto Blue Jays

Apr 18, 2026 - MLB

Arizona Diamondbacks
6 :  2
Toronto Blue Jays

Apr 17, 2026 - MLB

Arizona Diamondbacks
6 :  3
Toronto Blue Jays
Cleveland Guardians
Cleveland Guardians Latest matches
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 24, 2026 - MLB

Toronto Blue Jays
6 :  8
Cleveland Guardians

Apr 22, 2026 - MLB

Cleveland Guardians
0 :  2
Houston Astros

Apr 21, 2026 - MLB

Cleveland Guardians
8 :  5
Houston Astros

Apr 20, 2026 - MLB

Cleveland Guardians
2 :  9
Houston Astros

Apr 19, 2026 - MLB

Cleveland Guardians
8 :  4
Baltimore Orioles

Apr 18, 2026 - MLB

Cleveland Guardians
4 :  2
Baltimore Orioles
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 22, 2026 - MLB

Cleveland Guardians
0 :  2
Houston Astros

Apr 21, 2026 - MLB

Cleveland Guardians
8 :  5
Houston Astros

Apr 20, 2026 - MLB

Cleveland Guardians
2 :  9
Houston Astros

Apr 19, 2026 - MLB

Cleveland Guardians
8 :  4
Baltimore Orioles

Apr 18, 2026 - MLB

Cleveland Guardians
4 :  2
Baltimore Orioles

Apr 17, 2026 - MLB

Cleveland Guardians
4 :  6
Baltimore Orioles
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 24, 2026 - MLB

Toronto Blue Jays
6 :  8
Cleveland Guardians

Apr 15, 2026 - MLB

St. Louis Cardinals
5 :  3
Cleveland Guardians

Apr 14, 2026 - MLB

St. Louis Cardinals
6 :  5
Cleveland Guardians

Apr 13, 2026 - MLB

St. Louis Cardinals
3 :  9
Cleveland Guardians

Apr 12, 2026 - MLB

Atlanta Braves
13 :  1
Cleveland Guardians

Apr 11, 2026 - MLB

Atlanta Braves
0 :  6
Cleveland Guardians

Toronto Blue Jays against Cleveland Guardians : Head to Head (H2H)

Toronto Blue Jays

33 %

Cleveland Guardians

67 %

Apr 24, 2026 - MLB

Toronto Blue Jays
6 :  8
Cleveland Guardians

Jun 26, 2025 - MLB

Cleveland Guardians
0 :  6
Toronto Blue Jays

Jun 25, 2025 - MLB

Cleveland Guardians
5 :  4
Toronto Blue Jays

Jun 24, 2025 - MLB

Cleveland Guardians
6 :  10
Toronto Blue Jays

May 4, 2025 - MLB

Toronto Blue Jays
4 :  5
Cleveland Guardians

May 3, 2025 - MLB

Toronto Blue Jays
3 :  5
Cleveland Guardians

Toronto Blue Jays - Cleveland Guardians Key Points

  1. Toronto is 6-14 SU in its last 20 games.
  2. Toronto is 3-7 SU in its last 10 games against an opponent in the American League.
  3. Cleveland is 7-3 SU in its last 10 games against Toronto.
  4. Cleveland is 4-2 SU in its last 6 games.
Up to $250 to bet on Toronto Blue Jays - Cleveland Guardians! 

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Our Toronto Blue Jays vs Cleveland Guardians Prediction

Fearless Forecast: The Guardians steal one more road game against the Blue Jays 5-2

Back the Guardians to hack out another road win. Cleveland is 7-7 away from home this season, batting .223 with 4.1 runs per game. The Guardians are somehow finding ways to win ballgames despite their starters posting a 6.75 ERA over the last five games. Projected starter Joey Cantillo must tighten up his pitches because these Jays are batting .253 with 3.5 runs per game against left-handed pitchers this season. Still, I am confident Cleveland will get the job done, especially if they can get the lead during the final innings. The Guardians’ bullpen has posted a stellar 1.47 ERA over the last five games, allowing them to grind out these close wins recently.

Our betting prediction for the Cleveland Guardians vs. the Toronto Blue Jays: The Guardians will win

Prediction:

 

The Guardians will win

+122
$250 offered for betting!

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Toronto Blue Jays vs Cleveland Guardians Picks