St. Louis Cardinals vs Cleveland Guardians Prediction & Picks - MLB

USA - MLB

St. Louis Cardinals
4/14/26 19:45
Cleveland Guardians

Prediction:

 

Under 8 Total Runs

-101
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 by Matt Lowrimore | in MLB Picks

A full 15-game MLB slate is scheduled for Tuesday, which will include an interleague matchup between the St. Louis Cardinals and the Cleveland Guardians. Let’s take a look at the match statistics and predictions for this game between the Cardinals and the Guardians.

Cleveland is off to a great start and just won Game 1 against the Cardinals by a score of 9-3. The Guardians are now scheduled to start Joey Cantillo, who is 1-0 through three starts and has an ERA of 2.45. Given his hot start, Cantillo has a good chance to keep the Cardinals’ bats quiet, despite not having an ERA of 4.91 on the road.

As for St. Louis, they have been mediocre to start the season, but will start Michael McGreevy for Game 2 of this series. McGreevy enters this game with a record of 1-1 and an ERA of 2.16 through three games. In his only home start, McGreevy pitched 6.0 innings of shutout baseball, which suggests he could limit the Guardians’ bats.

St. Louis Cardinals vs Cleveland Guardians Form

Table

Teams Pts P W L
11 St. Louis Cardinals
0.525 80 42 38
12 Cleveland Guardians
0.518 83 43 40

St. Louis Cardinals and Cleveland Guardians Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 13, 2026 - MLB

St. Louis Cardinals
3 :  9
Cleveland Guardians

Apr 12, 2026 - MLB

St. Louis Cardinals
3 :  9
Boston Red Sox

Apr 11, 2026 - MLB

St. Louis Cardinals
1 :  7
Boston Red Sox

Apr 10, 2026 - MLB

St. Louis Cardinals
3 :  2
Boston Red Sox

Apr 8, 2026 - MLB

Washington Nationals
1 :  6
St. Louis Cardinals

Apr 7, 2026 - MLB

Washington Nationals
6 :  7
St. Louis Cardinals
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 13, 2026 - MLB

St. Louis Cardinals
3 :  9
Cleveland Guardians

Apr 12, 2026 - MLB

St. Louis Cardinals
3 :  9
Boston Red Sox

Apr 11, 2026 - MLB

St. Louis Cardinals
1 :  7
Boston Red Sox

Apr 10, 2026 - MLB

St. Louis Cardinals
3 :  2
Boston Red Sox

Apr 1, 2026 - MLB

St. Louis Cardinals
2 :  1
New York Mets

Mar 31, 2026 - MLB

St. Louis Cardinals
3 :  0
New York Mets
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 8, 2026 - MLB

Washington Nationals
1 :  6
St. Louis Cardinals

Apr 7, 2026 - MLB

Washington Nationals
6 :  7
St. Louis Cardinals

Apr 6, 2026 - MLB

Washington Nationals
9 :  6
St. Louis Cardinals

Apr 5, 2026 - MLB

Detroit Tigers
3 :  5
St. Louis Cardinals

Apr 4, 2026 - MLB

Detroit Tigers
11 :  6
St. Louis Cardinals

Apr 3, 2026 - MLB

Detroit Tigers
4 :  0
St. Louis Cardinals
Cleveland Guardians
Cleveland Guardians Latest matches
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 13, 2026 - MLB

St. Louis Cardinals
3 :  9
Cleveland Guardians

Apr 12, 2026 - MLB

Atlanta Braves
13 :  1
Cleveland Guardians

Apr 11, 2026 - MLB

Atlanta Braves
0 :  6
Cleveland Guardians

Apr 10, 2026 - MLB

Atlanta Braves
11 :  5
Cleveland Guardians

Apr 8, 2026 - MLB

Cleveland Guardians
10 :  2
Kansas City Royals

Apr 7, 2026 - MLB

Cleveland Guardians
2 :  1
Kansas City Royals
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 8, 2026 - MLB

Cleveland Guardians
10 :  2
Kansas City Royals

Apr 7, 2026 - MLB

Cleveland Guardians
2 :  1
Kansas City Royals

Apr 6, 2026 - MLB

Cleveland Guardians
2 :  4
Kansas City Royals

Apr 5, 2026 - MLB

Cleveland Guardians
6 :  5
Chicago Cubs

Apr 5, 2026 - MLB

Cleveland Guardians
0 :  1
Chicago Cubs

Apr 3, 2026 - MLB

Cleveland Guardians
4 :  1
Chicago Cubs
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 13, 2026 - MLB

St. Louis Cardinals
3 :  9
Cleveland Guardians

Apr 12, 2026 - MLB

Atlanta Braves
13 :  1
Cleveland Guardians

Apr 11, 2026 - MLB

Atlanta Braves
0 :  6
Cleveland Guardians

Apr 10, 2026 - MLB

Atlanta Braves
11 :  5
Cleveland Guardians

Apr 1, 2026 - MLB

Los Angeles Dodgers
1 :  4
Cleveland Guardians

Mar 31, 2026 - MLB

Los Angeles Dodgers
4 :  1
Cleveland Guardians

St. Louis Cardinals against Cleveland Guardians : Head to Head (H2H)

St. Louis Cardinals

67 %

Cleveland Guardians

33 %

Apr 13, 2026 - MLB

St. Louis Cardinals
3 :  9
Cleveland Guardians

Jun 29, 2025 - MLB

Cleveland Guardians
0 :  7
St. Louis Cardinals

Jun 28, 2025 - MLB

Cleveland Guardians
6 :  9
St. Louis Cardinals

St. Louis Cardinals - Cleveland Guardians Key Points

  1. Joey Cantillo has an ERA of 2.45
  2. Joey Cantillo has an ERA of 4.91 on the road
  3. Michael McGreevy has an ERA of 2.16
  4. Michael McGreevy has an ERA of 0.00 at home

Our St. Louis Cardinals vs Cleveland Guardians Prediction

Cleveland is the small favorite in this game; however, with both starting pitchers having been excellent to start the season, the under looks to be the best betting option. Game 1 featured a total of 12 runs, but with a much better pitching matchup, far fewer runs should be expected. 

Looking at the away/home splits, McGreevy did not allow an earned run in his lone home start, while Cantillo has only allowed two earned runs in his one road start. He only lasted 3.2 innings in his start on the road; however, with both starters having allowed minimal damage, our St. Louis Cardinals vs Cleveland Guardians prediction is: Under 8 Total Runs.

Prediction:

 

Under 8 Total Runs

-101
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

St. Louis Cardinals vs Cleveland Guardians Picks