San Diego Padres vs Cleveland Guardians Prediction & Picks - MLB

Prediction published on 4/1/25, 6:28 PM  by Carlos Zabala | Modified on 2/16/26 at 4:24 PM in MLB Picks

Nearly all of the Padres' bats to start 2025 have contributed well for a team looking to keep pace against the Dodgers. In Monday's game, the Padres scored four runs in the second inning off Tatis, driving in two of them with a hit. However, the Guardians also brought Dominican power, and, returning to the lineup after spraining his wrist against the Royals, José Ramírez hit his first home run of the season.

Betting odds placed the Padres as favorites for Game 2 at around -165 over the Guardians hours before the Game 1 playoff even began. For the second game of the series at Petco, between two of the most effective home teams in 2024, Allen will start for the Guardians and King for the Padres in what could be a pitching duel.

In King's first start this season, the Padres won 7-4 at Petco Park, but King did not even pitch 3 innings against the Braves, allowing 3 ER and giving 4 BB, filling up with pitches very quickly, and an even more ruthless lineup awaits him in the Guardians' bats on Tuesday.