San Diego Padres vs Cleveland Guardians Prediction & Picks - MLB

Prediction published on 3/31/25, 6:20 PM  by Carlos Zabala | Modified on 2/16/26 at 4:31 PM in MLB Picks

In 2024, the Padres' record at Petco Park was 48-36, and in the 2025 season, they swept the Braves, blanking them 5-0 in the final game of the series with a spectacular 7-inning outing by Pivetta, where he allowed only one hit and struck out four. In that victory, Manny Machado, along with Bogaerts and Merill, had an RBI double, and Tatis Jr. drove in the last run of the game for the Padres, who managed nine hits on Sunday night.

Now, back at Petco Park, the Padres are preparing to host another tough team in the Cleveland Guardians, who won their division last season and already won their first series of 2025 against the Royals in Kansas City. The Guardians finished last in the series with a 6-2 victory. Stephen Vogt's team was without superstar Ramírez for the decisive game, but 24-year-old Kyle Manzardo has taken over the Guardians' offense, going 3-for-6 with 4 RBIs in an encouraging start to the season.

In 2024, the Padres won the series against the Guardians in Cleveland 2-1. The scheduled pitchers for Monday's game are Ortiz for the Guardians and Hart for the Padres.