Philadelphia Phillies vs Cleveland Guardians Prediction & Picks - MLB

USA - MLB

Philadelphia Phillies
5/23/26 16:05
Cleveland Guardians

Prediction:

 

Philadelphia to win

-190
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 by Bill Christy | in MLB Picks

The Cleveland Guardians (31-22) and the Philadelphia Phillies (25-26) play game two of their 3 game series this afternoon in Philly. The Guardians took game one in a low-scoring affair.

Cristopher Sanchez of the Phillies looked tremendous once again. Coming off a complete game shutout, Sanchez tossed 8 innings of no-run ball while allowing just 4 hits. However, closer Jhoan Duran gave up a solo home run to Kyle Manzardo in the top of the 9th that would be the difference.

Gavin Williams of the Guardians had an even stronger game than Sanchez. He did the same amount of work and allowed the same number of hits, but struck out 11 to Sanchez’s 6 batters. After scoring in the 9th, the Guardians brought in closer Cade Smith, who batted down the top of the Phillies lineup to get the save and secure the win.

Today, the Phillies should have a decisive advantage on the mound. Zach Wheeler will face off with Slade Cecconi. Wheeler is 3-0 since coming back from injury and is carrying a 1.99 ERA. Cecconi is just 3-4 on the season and has an ERA of over 5.00. The Phillies' bats that were quiet yesterday should have ample opportunities to get some runs here against Cecconi.

Philadelphia Phillies vs Cleveland Guardians Form

Table

Teams Pts P W L
6 Cleveland Guardians
0.565 62 35 27
14 Philadelphia Phillies
0.517 60 31 29

Philadelphia Phillies and Cleveland Guardians Latest Matches

Philadelphia Phillies
Philadelphia Phillies Latest matches
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 22, 2026 - MLB

Philadelphia Phillies
0 :  1
Cleveland Guardians

May 20, 2026 - MLB

Philadelphia Phillies
4 :  9
Cincinnati Reds

May 19, 2026 - MLB

Philadelphia Phillies
1 :  4
Cincinnati Reds

May 18, 2026 - MLB

Philadelphia Phillies
5 :  4
Cincinnati Reds

May 17, 2026 - MLB

Pittsburgh Pirates
0 :  6
Philadelphia Phillies

May 16, 2026 - MLB

Pittsburgh Pirates
0 :  6
Philadelphia Phillies
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 22, 2026 - MLB

Philadelphia Phillies
0 :  1
Cleveland Guardians

May 20, 2026 - MLB

Philadelphia Phillies
4 :  9
Cincinnati Reds

May 19, 2026 - MLB

Philadelphia Phillies
1 :  4
Cincinnati Reds

May 18, 2026 - MLB

Philadelphia Phillies
5 :  4
Cincinnati Reds

May 10, 2026 - MLB

Philadelphia Phillies
6 :  0
Colorado Rockies

May 9, 2026 - MLB

Philadelphia Phillies
9 :  3
Colorado Rockies
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 17, 2026 - MLB

Pittsburgh Pirates
0 :  6
Philadelphia Phillies

May 16, 2026 - MLB

Pittsburgh Pirates
0 :  6
Philadelphia Phillies

May 15, 2026 - MLB

Pittsburgh Pirates
9 :  11
Philadelphia Phillies

May 14, 2026 - MLB

Boston Red Sox
1 :  3
Philadelphia Phillies

May 13, 2026 - MLB

Boston Red Sox
3 :  1
Philadelphia Phillies

May 12, 2026 - MLB

Boston Red Sox
1 :  2
Philadelphia Phillies
Cleveland Guardians
Cleveland Guardians Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 22, 2026 - MLB

Philadelphia Phillies
0 :  1
Cleveland Guardians

May 21, 2026 - MLB

Detroit Tigers
1 :  3
Cleveland Guardians

May 20, 2026 - MLB

Detroit Tigers
2 :  3
Cleveland Guardians

May 19, 2026 - MLB

Detroit Tigers
3 :  4
Cleveland Guardians

May 18, 2026 - MLB

Detroit Tigers
2 :  8
Cleveland Guardians

May 17, 2026 - MLB

Cleveland Guardians
10 :  3
Cincinnati Reds
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 17, 2026 - MLB

Cleveland Guardians
10 :  3
Cincinnati Reds

May 16, 2026 - MLB

Cleveland Guardians
7 :  4
Cincinnati Reds

May 15, 2026 - MLB

Cleveland Guardians
6 :  7
Cincinnati Reds

May 13, 2026 - MLB

Cleveland Guardians
4 :  2
Los Angeles Angels

May 12, 2026 - MLB

Cleveland Guardians
3 :  2
Los Angeles Angels

May 11, 2026 - MLB

Cleveland Guardians
7 :  2
Los Angeles Angels
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 22, 2026 - MLB

Philadelphia Phillies
0 :  1
Cleveland Guardians

May 21, 2026 - MLB

Detroit Tigers
1 :  3
Cleveland Guardians

May 20, 2026 - MLB

Detroit Tigers
2 :  3
Cleveland Guardians

May 19, 2026 - MLB

Detroit Tigers
3 :  4
Cleveland Guardians

May 18, 2026 - MLB

Detroit Tigers
2 :  8
Cleveland Guardians

May 7, 2026 - MLB

Kansas City Royals
5 :  8
Cleveland Guardians

Philadelphia Phillies against Cleveland Guardians : Head to Head (H2H)

Philadelphia Phillies

60 %

Cleveland Guardians

40 %

May 22, 2026 - MLB

Philadelphia Phillies
0 :  1
Cleveland Guardians

May 11, 2025 - MLB

Cleveland Guardians
0 :  3
Philadelphia Phillies

May 10, 2025 - MLB

Cleveland Guardians
1 :  7
Philadelphia Phillies

May 9, 2025 - MLB

Cleveland Guardians
6 :  0
Philadelphia Phillies

Jul 27, 2024 - MLB

Philadelphia Phillies
8 :  0
Cleveland Guardians

Philadelphia Phillies - Cleveland Guardians Key Points

  1. Cleveland is 2-5 SU in its last 7 games against an opponent in the National League East Division.
  2. Philadelphia is 12-5 SU in its last 17 games when playing as the favorite.
  3. Philadelphia is 5-2 SU in its last 7 games played on a Saturday.
  4. Philadelphia is 5-0 SU in all 5 of Wheeler’s starts this season.

Our Philadelphia Phillies vs Cleveland Guardians Prediction

Wheeler has looked to be in mid-season for right out of the gate this season. He has allowed just 7 runs in his 31.1 innings of work to date. He is coming off his best start of the season where he went 7 innings of scoreless pitching against the Pirates. He should need limited run support in this one and is likely to get exactly what he needs with the Phillies facing a weak Cecconi in this one.

Our prediction for Philadelphia Phillies vs Cleveland Guardians: Philadelphia to win

Prediction:

 

Philadelphia to win

-190
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Philadelphia Phillies vs Cleveland Guardians Picks