Philadelphia Phillies vs Cleveland Guardians Prediction & Picks - MLB

USA - MLB

Philadelphia Phillies
5/22/26 18:40
Cleveland Guardians

Prediction:

 

Under 7

-115
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 by Bill Christy | in MLB Picks

The weekend series between the Cleveland Guardians (30-22) and the Philadelphia Phillies (25-25) will begin tonight in Philadelphia.

Cleveland is coming into the series on the back of a 6-game winning streak. After winning 2 of the last 3 in their series with the Reds, the Guardians completed a 4-game road sweep of the Detroit Tigers. It was pitching that made their last 3 games winnable. While they only scored a total of 10 runs, they were able to hold opponents to just 6 total runs.

Philly has been strong ever since they made their managerial change. Don Mattingly has seemed to be the change this team needed in leadership. They have fought their way back to .500 on the season, but are facing a possible 3-game losing streak here. They lost their last 2 games to the Reds, but will have their top arm on the mound here tonight.

The Phillies will start Cristopher Sanchez, who is 5-2 with a 1.82 ERA. Gavin Williams will go for the Guardians, who have also been stout this season. He is 6-3 with a 3.67 ERA. With both teams hitting under .235 and ranking outside the top 25 in MLB, runs may be tough to come by in this series-opening game.

Philadelphia Phillies vs Cleveland Guardians Form

Table

Teams Pts P W L
6 Cleveland Guardians
0.565 62 35 27
14 Philadelphia Phillies
0.517 60 31 29

Philadelphia Phillies and Cleveland Guardians Latest Matches

Philadelphia Phillies
Philadelphia Phillies Latest matches
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 20, 2026 - MLB

Philadelphia Phillies
4 :  9
Cincinnati Reds

May 19, 2026 - MLB

Philadelphia Phillies
1 :  4
Cincinnati Reds

May 18, 2026 - MLB

Philadelphia Phillies
5 :  4
Cincinnati Reds

May 17, 2026 - MLB

Pittsburgh Pirates
0 :  6
Philadelphia Phillies

May 16, 2026 - MLB

Pittsburgh Pirates
0 :  6
Philadelphia Phillies

May 15, 2026 - MLB

Pittsburgh Pirates
9 :  11
Philadelphia Phillies
L W W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 20, 2026 - MLB

Philadelphia Phillies
4 :  9
Cincinnati Reds

May 19, 2026 - MLB

Philadelphia Phillies
1 :  4
Cincinnati Reds

May 18, 2026 - MLB

Philadelphia Phillies
5 :  4
Cincinnati Reds

May 10, 2026 - MLB

Philadelphia Phillies
6 :  0
Colorado Rockies

May 9, 2026 - MLB

Philadelphia Phillies
9 :  3
Colorado Rockies

May 8, 2026 - MLB

Philadelphia Phillies
7 :  9
Colorado Rockies
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 17, 2026 - MLB

Pittsburgh Pirates
0 :  6
Philadelphia Phillies

May 16, 2026 - MLB

Pittsburgh Pirates
0 :  6
Philadelphia Phillies

May 15, 2026 - MLB

Pittsburgh Pirates
9 :  11
Philadelphia Phillies

May 14, 2026 - MLB

Boston Red Sox
1 :  3
Philadelphia Phillies

May 13, 2026 - MLB

Boston Red Sox
3 :  1
Philadelphia Phillies

May 12, 2026 - MLB

Boston Red Sox
1 :  2
Philadelphia Phillies
Cleveland Guardians
Cleveland Guardians Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 21, 2026 - MLB

Detroit Tigers
1 :  3
Cleveland Guardians

May 20, 2026 - MLB

Detroit Tigers
2 :  3
Cleveland Guardians

May 19, 2026 - MLB

Detroit Tigers
3 :  4
Cleveland Guardians

May 18, 2026 - MLB

Detroit Tigers
2 :  8
Cleveland Guardians

May 17, 2026 - MLB

Cleveland Guardians
10 :  3
Cincinnati Reds

May 16, 2026 - MLB

Cleveland Guardians
7 :  4
Cincinnati Reds
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 17, 2026 - MLB

Cleveland Guardians
10 :  3
Cincinnati Reds

May 16, 2026 - MLB

Cleveland Guardians
7 :  4
Cincinnati Reds

May 15, 2026 - MLB

Cleveland Guardians
6 :  7
Cincinnati Reds

May 13, 2026 - MLB

Cleveland Guardians
4 :  2
Los Angeles Angels

May 12, 2026 - MLB

Cleveland Guardians
3 :  2
Los Angeles Angels

May 11, 2026 - MLB

Cleveland Guardians
7 :  2
Los Angeles Angels
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 21, 2026 - MLB

Detroit Tigers
1 :  3
Cleveland Guardians

May 20, 2026 - MLB

Detroit Tigers
2 :  3
Cleveland Guardians

May 19, 2026 - MLB

Detroit Tigers
3 :  4
Cleveland Guardians

May 18, 2026 - MLB

Detroit Tigers
2 :  8
Cleveland Guardians

May 7, 2026 - MLB

Kansas City Royals
5 :  8
Cleveland Guardians

May 6, 2026 - MLB

Kansas City Royals
1 :  3
Cleveland Guardians

Philadelphia Phillies against Cleveland Guardians : Head to Head (H2H)

Philadelphia Phillies

75 %

Cleveland Guardians

25 %

May 11, 2025 - MLB

Cleveland Guardians
0 :  3
Philadelphia Phillies

May 10, 2025 - MLB

Cleveland Guardians
1 :  7
Philadelphia Phillies

May 9, 2025 - MLB

Cleveland Guardians
6 :  0
Philadelphia Phillies

Jul 27, 2024 - MLB

Philadelphia Phillies
8 :  0
Cleveland Guardians

Philadelphia Phillies - Cleveland Guardians Key Points

  1. The total has gone UNDER in 5 of Cleveland’s last 6 games against Philadelphia.
  2. The total has gone UNDER in 5 of Cleveland’s last 5 games when playing on the road against Philadelphia.
  3. The total has gone UNDER in 8 of Philadelphia’s last 10 games.
  4. The total has gone UNDER in 5 of Philadelphia’s last 6 games when playing as the favorite.

Our Philadelphia Phillies vs Cleveland Guardians Prediction

This should be the strongest pitching matchup of the series. Sanchez is coming off a complete game shutout against the Pirates in his last start. He struck out 13 and only allowed 6 hits in the win. Gavin Williams went 6 strong against the Reds in his last start. He allowed just 2 runs and struck out 7 in the win. We like both to pitch well again here and hold the scoring to a minimum. If they can go deep in the game, there is no chance these teams will post more than 7 runs.

Our prediction for Philadelphia Phillies vs Cleveland Guardians: Under 7

Prediction:

 

Under 7

-115
$350 offered for betting!

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Philadelphia Phillies vs Cleveland Guardians Picks