Minnesota Twins vs Cleveland Guardians Prediction & Picks - MLB

Prediction published on 9/20/25, 10:26 AM  by Carlos Zabala | Modified on 9/20/25 at 4:25 PM in MLB Picks

The Guards were in the 2024 playoffs; with nine games remaining, Cleveland appears to be the only team still without a playoff spot but still has a good chance of getting there. They gave themselves that chance, going on a roll starting on September 11th, when they beat the Royals 3-2 and started a seven-game winning streak that continues. With this, Cleveland is only 1.5 games behind the Astros and the Red Sox, hoping to capitalize on any slip-ups from those two teams in the final weeks of the regular season.

In Friday's game, the Guards won against the Twins in Minneapolis; the Guards have been dominant in their home series against Minnesota this year, winning seven of their last 10 games against each other in 2025. Friday's game ended 6-2. It was a game with even betting odds, with the Guardians favored at just -115. Cleveland's key bats showed up. In the late innings, with the game tied 2-2: Bo Naylor. He hit a two-run single, and in the ninth, Kwan hit an RBI double.

Game 2 of this four-game series at Target Field will be played in the afternoon, with an attractive pitching duel between Slade Cecconi for Cleveland and Joe Ryan for the Twins.