Minnesota Twins vs Cleveland Guardians Prediction & Picks - MLB

USA - MLB

Minnesota Twins
5/21/25 15:55
Cleveland Guardians

Prediction:

 

Twins will win

-118
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 by Lou Aguila | in MLB Picks

The Minnesota Twins will slug it out with the Cleveland Guardians on the back of a double-header on Wednesday at Target Field.

The Twins will march into Wednesday’s double-header schedule with a 1-4 record over their last 5 games. Minnesota’s 13-game win streak came to an end at the hands of the Milwaukee Brewers 2-5 on Sunday, and they are trying to avoid back-to-back defeats when Game 1 of their series against the Guardians resume on Wednesday after it was postponed in the fourth inning due to rain.

The Guardians are seeking their first win in five games after last week’s slump extended over the weekend. Cleveland’s level play on the mound and behind the plate has significantly dropped over their last five games, during which they have batted .226 with 2.6 runs per game and pitched a 4.29 ERA.

Minnesota Twins vs Cleveland Guardians Form

Table

Teams Pts P W L
10 Cleveland Guardians
0.543 162 88 74
27 Minnesota Twins
0.432 162 70 92

Minnesota Twins and Cleveland Guardians Latest Matches

Minnesota Twins
Minnesota Twins Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 14, 2025 - MLB

Baltimore Orioles
6 :  8
Minnesota Twins

May 14, 2025 - MLB

Baltimore Orioles
3 :  6
Minnesota Twins

May 11, 2025 - MLB

Minnesota Twins
7 :  6
San Francisco Giants

May 9, 2025 - MLB

Minnesota Twins
3 :  1
San Francisco Giants

May 8, 2025 - MLB

Minnesota Twins
5 :  2
Baltimore Orioles

May 7, 2025 - MLB

Minnesota Twins
5 :  2
Baltimore Orioles
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 11, 2025 - MLB

Minnesota Twins
7 :  6
San Francisco Giants

May 9, 2025 - MLB

Minnesota Twins
3 :  1
San Francisco Giants

May 8, 2025 - MLB

Minnesota Twins
5 :  2
Baltimore Orioles

May 7, 2025 - MLB

Minnesota Twins
5 :  2
Baltimore Orioles

May 6, 2025 - MLB

Minnesota Twins
9 :  1
Baltimore Orioles

Apr 27, 2025 - MLB

Minnesota Twins
5 :  0
Los Angeles Angels
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2025 - MLB

Baltimore Orioles
6 :  8
Minnesota Twins

May 14, 2025 - MLB

Baltimore Orioles
3 :  6
Minnesota Twins

May 4, 2025 - MLB

Boston Red Sox
4 :  5
Minnesota Twins

May 1, 2025 - MLB

Cleveland Guardians
4 :  3
Minnesota Twins

Apr 30, 2025 - MLB

Cleveland Guardians
4 :  2
Minnesota Twins

Apr 29, 2025 - MLB

Cleveland Guardians
2 :  1
Minnesota Twins
Cleveland Guardians
Cleveland Guardians Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 13, 2025 - MLB

Cleveland Guardians
2 :  0
Milwaukee Brewers

May 10, 2025 - MLB

Cleveland Guardians
1 :  7
Philadelphia Phillies

May 7, 2025 - MLB

Washington Nationals
6 :  8
Cleveland Guardians

May 4, 2025 - MLB

Toronto Blue Jays
4 :  5
Cleveland Guardians

May 3, 2025 - MLB

Toronto Blue Jays
3 :  5
Cleveland Guardians

May 2, 2025 - MLB

Toronto Blue Jays
5 :  3
Cleveland Guardians
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 13, 2025 - MLB

Cleveland Guardians
2 :  0
Milwaukee Brewers

May 10, 2025 - MLB

Cleveland Guardians
1 :  7
Philadelphia Phillies

May 1, 2025 - MLB

Cleveland Guardians
4 :  3
Minnesota Twins

Apr 30, 2025 - MLB

Cleveland Guardians
4 :  2
Minnesota Twins

Apr 29, 2025 - MLB

Cleveland Guardians
2 :  1
Minnesota Twins

Apr 28, 2025 - MLB

Cleveland Guardians
1 :  11
Minnesota Twins
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 7, 2025 - MLB

Washington Nationals
6 :  8
Cleveland Guardians

May 4, 2025 - MLB

Toronto Blue Jays
4 :  5
Cleveland Guardians

May 3, 2025 - MLB

Toronto Blue Jays
3 :  5
Cleveland Guardians

May 2, 2025 - MLB

Toronto Blue Jays
5 :  3
Cleveland Guardians

Apr 20, 2025 - MLB

Pittsburgh Pirates
4 :  5
Cleveland Guardians

Apr 19, 2025 - MLB

Pittsburgh Pirates
0 :  3
Cleveland Guardians

Minnesota Twins against Cleveland Guardians : Head to Head (H2H)

Minnesota Twins

33 %

Cleveland Guardians

67 %

May 1, 2025 - MLB

Cleveland Guardians
4 :  3
Minnesota Twins

Apr 30, 2025 - MLB

Cleveland Guardians
4 :  2
Minnesota Twins

Apr 29, 2025 - MLB

Cleveland Guardians
2 :  1
Minnesota Twins

Apr 28, 2025 - MLB

Cleveland Guardians
1 :  11
Minnesota Twins

Sep 19, 2024 - MLB

Cleveland Guardians
3 :  2
Minnesota Twins

Sep 17, 2024 - MLB

Cleveland Guardians
1 :  4
Minnesota Twins

Minnesota Twins - Cleveland Guardians Key Points

  1. Minnesota is 9-0 SU in its last 9 games at home.
  2. Cleveland is 1-4 SU in its last 5 games.
  3. Cleveland is 2-4 SU in its last 6 games on the road.
  4. Minnesota is 13-1 SU in its last 14 games.

Our Minnesota Twins vs Cleveland Guardians Prediction

Fearless Forecast: Minnesota takes Game 2 with another dazzling game from Chris Paddack

Why we should bet on the Twins to win: Minnesota is starting Chris Paddack (2.15 ERA), who pitched the Twins to a win in his last 3 starts. Despite losing his first two starts vs. the Guardians, Paddack actually played decently as he allowed a total of 3 earned runs in 13.0 total pitched innings.

Why we should NOT bet on the Guardians to win: Apart from they are only 11-13 on the road this season, Cleveland is averaging 2.7 runs per game over their last five games, which should be a cause for concern for a team that is also struggling to contain opponents. Wednesday’s starter, Gavin Williams, allowed two earned runs in a 5-9 loss to the Brewers and threw 4 earned runs in a 4-11 loss to Minnesota on April 28.

Our betting prediction for the Minnesota Twins vs. the Cleveland Guardians: The Twins will win.

Prediction:

 

Twins will win

-118
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Minnesota Twins vs Cleveland Guardians Picks