Houston Astros vs Cleveland Guardians Prediction & Picks - MLB

USA - MLB

Houston Astros
6/21/26 14:10
Cleveland Guardians

Prediction:

 

Cleveland Guardians win the match

+113
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 by Carlos Zabala | in MLB Picks

In the second game of the series between the Astros and Guardians at Daikin Park, the bat of the red-hot Dominican and MVP candidate Yordan Álvarez wasn't as prominent. However, the bat of Australian and 2024 number one draft pick Travis Bazzana stood out, delivering his best performance since reaching the major leagues in the previous game, collecting four hits, two of them home runs, and driving in five runs. The teams split the series, and the Astros and Guards will play the rubber match on Sunday, with the home team listed as -143 favorites by the bookmakers.

An interesting pitching duel is set for the next game, one in which Kai-Wei Teng, with a 3-6 record, 54.1 IP, and 58 strikeouts, will start for the Astros. The Taiwanese pitcher once again struggled; although he generated many whiffs, when he did allow contact, it was pure power. After a solid May, the opposite has been true for him, as he had a rather poor June in which he allowed 17 runs.

Houston Astros vs Cleveland Guardians Form

Table

Teams Pts P W L
8 Cleveland Guardians
0.532 77 41 36
22 Houston Astros
0.462 78 36 42

Houston Astros and Cleveland Guardians Latest Matches

Houston Astros
Houston Astros Latest matches
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 20, 2026 - MLB

Houston Astros
1 :  8
Cleveland Guardians

Jun 19, 2026 - MLB

Houston Astros
9 :  3
Cleveland Guardians

Jun 17, 2026 - MLB

Houston Astros
4 :  2
Detroit Tigers

Jun 16, 2026 - MLB

Houston Astros
4 :  2
Detroit Tigers

Jun 15, 2026 - MLB

Houston Astros
3 :  9
Detroit Tigers

Jun 14, 2026 - MLB

Kansas City Royals
4 :  0
Houston Astros
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 20, 2026 - MLB

Houston Astros
1 :  8
Cleveland Guardians

Jun 19, 2026 - MLB

Houston Astros
9 :  3
Cleveland Guardians

Jun 17, 2026 - MLB

Houston Astros
4 :  2
Detroit Tigers

Jun 16, 2026 - MLB

Houston Astros
4 :  2
Detroit Tigers

Jun 15, 2026 - MLB

Houston Astros
3 :  9
Detroit Tigers

Jun 7, 2026 - MLB

Houston Astros
0 :  5
Athletics
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 14, 2026 - MLB

Kansas City Royals
4 :  0
Houston Astros

Jun 13, 2026 - MLB

Kansas City Royals
7 :  8
Houston Astros

Jun 12, 2026 - MLB

Kansas City Royals
8 :  10
Houston Astros

Jun 10, 2026 - MLB

Los Angeles Angels
3 :  2
Houston Astros

Jun 9, 2026 - MLB

Los Angeles Angels
10 :  1
Houston Astros

Jun 8, 2026 - MLB

Los Angeles Angels
4 :  5
Houston Astros
Cleveland Guardians
Cleveland Guardians Latest matches
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 20, 2026 - MLB

Houston Astros
1 :  8
Cleveland Guardians

Jun 19, 2026 - MLB

Houston Astros
9 :  3
Cleveland Guardians

Jun 18, 2026 - MLB

Milwaukee Brewers
2 :  4
Cleveland Guardians

Jun 17, 2026 - MLB

Milwaukee Brewers
9 :  4
Cleveland Guardians

Jun 16, 2026 - MLB

Milwaukee Brewers
2 :  1
Cleveland Guardians

Jun 13, 2026 - MLB

Cleveland Guardians
3 :  1
Detroit Tigers
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 13, 2026 - MLB

Cleveland Guardians
3 :  1
Detroit Tigers

Jun 12, 2026 - MLB

Cleveland Guardians
3 :  2
Detroit Tigers

Jun 10, 2026 - MLB

Cleveland Guardians
4 :  8
New York Yankees

Jun 9, 2026 - MLB

Cleveland Guardians
2 :  3
New York Yankees

Jun 8, 2026 - MLB

Cleveland Guardians
5 :  7
New York Yankees

May 31, 2026 - MLB

Cleveland Guardians
4 :  9
Boston Red Sox
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 20, 2026 - MLB

Houston Astros
1 :  8
Cleveland Guardians

Jun 19, 2026 - MLB

Houston Astros
9 :  3
Cleveland Guardians

Jun 18, 2026 - MLB

Milwaukee Brewers
2 :  4
Cleveland Guardians

Jun 17, 2026 - MLB

Milwaukee Brewers
9 :  4
Cleveland Guardians

Jun 16, 2026 - MLB

Milwaukee Brewers
2 :  1
Cleveland Guardians

Jun 7, 2026 - MLB

Texas Rangers
10 :  0
Cleveland Guardians

Houston Astros against Cleveland Guardians : Head to Head (H2H)

Houston Astros

50 %

Cleveland Guardians

50 %

Jun 20, 2026 - MLB

Houston Astros
1 :  8
Cleveland Guardians

Jun 19, 2026 - MLB

Houston Astros
9 :  3
Cleveland Guardians

Apr 22, 2026 - MLB

Cleveland Guardians
0 :  2
Houston Astros

Apr 21, 2026 - MLB

Cleveland Guardians
8 :  5
Houston Astros

Apr 20, 2026 - MLB

Cleveland Guardians
2 :  9
Houston Astros

Jul 9, 2025 - MLB

Houston Astros
2 :  4
Cleveland Guardians

Houston Astros - Cleveland Guardians Key Points

  1. The Astros' SLG is seventh best in MLB at .416
  2. The Guardians' pitching K/9 ratio is third best in MLB
  3. The Guardians have a 22-19 record this season on the road
  4. The Astros have stolen the fewest bases this season in all of MLB

Our Houston Astros vs Cleveland Guardians Prediction

The betting history reveals that betting on the Guardians has been a fairly profitable business, while bettors who relied on the Astros' money line every day would be in the red.

The Astros have an 11-5 record when they were favored in betting odds at home, but Cleveland managed 15 wins this season as the underdog on the road.

Our predcition for Astros vs Guardians is: Guardians ML.

Prediction:

 

Cleveland Guardians win the match

+113
$200 offered for betting!

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Houston Astros vs Cleveland Guardians Picks