Cincinnati Reds vs Cleveland Guardians Prediction & Picks - MLB
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by Matt Lowrimore | in MLB Picks
Every MLB team will be in action on Wednesday, one of which will feature an Interleague matchup between the Cincinnati Reds and the Cleveland Guardians. Let’s take a look at the match statistics and predictions for this game between the Reds and the Guardians.
Cleveland enters this game just above .500, and with that, is currently in second place in the American League Central division. Set to start this game for Cleveland will be Joey Cantillo, who has a record of 8-6 and an ERA of 4.06. To go along with his subpar number, Cantillo has also struggled on the road this season, making it likely the Reds will be able to take advantage.
As for Cincinnati, they enter this game several games under .500 and, because of that, are currently in last place in the National League Central division. Starting this game for the Reds will be Brady Singer, who has a record of 5-9 and an ERA of 4.53. Brady has been much better when pitching at home this season, suggesting he will be able to do the same against the Guardians.
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Cincinnati Reds vs Cleveland Guardians Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
19
|
0.487 | 119 | 58 | 61 |
|
21
|
0.479 | 117 | 56 | 61 |
Cincinnati Reds and Cleveland Guardians Latest Matches
4/6 (67%)
2/6 (33%)
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2/6 (33%)
4/6 (67%)
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4/6 (67%)
2/6 (33%)
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1/6 (17%)
5/6 (83%)
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3/6 (50%)
3/6 (50%)
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2/6 (33%)
4/6 (67%)
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Cincinnati Reds against Cleveland Guardians : Head to Head (H2H)
33 %
67 %
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Mar 22, 2026 - MLB Spring Training
Cincinnati Reds - Cleveland Guardians Key Points
- Joey Cantillo has an ERA of 4.02 this season
- Joey Cantillo has an ERA of 4.20 on the road this season
- Brady Singer has an ERA of 4.53 this season
- Brady Singer has an ERA of 2.98 at home this season
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Our Cincinnati Reds vs Cleveland Guardians Prediction
The Guardians are the clear favorite in this game; however, the Reds look to be the best betting option. This is because of the home/away splits between the two starting pitchers. Cantillo has made 12 away starts this season, having allowed 32 runs (28 earned) over 60.0 innings. Singer, on the other hand, has made nine home starts, in which he has allowed 17 runs (16 earned) over 48.1 innings.
The Reds have not been a great team this season, but given that they appear to have the advantage on the mound, our Cincinnati Reds vs Cleveland Guardians prediction is: Cincinnati Reds ML.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
