Chicago White Sox vs Cleveland Guardians Prediction & Picks - MLB
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The Chicago White Sox have drawn level with the Cleveland Guardians at the top of the AL Central standings, as a result of consecutive wins over their rivals. That means Wednesday's series finale between the teams will decide which franchise leaves Guaranteed Rate Field as divisional leaders.
Both of the opening two games in the series went down to the wire and were decided by just a single run. Five runs in the final three innings saw Chicago secure a thrilling 6-5 win in game one, whilst a rock solid defensive effort saw them edge a tense second game by two runs to one.
Overall, both teams have struggled over the last two weeks and have disappointing 4-6 records from their last ten games. With the Minnesota Twins just three games back in the divisional race, both the White Sox and Guardians will be desperate to rediscover their best form as we approach the business end of the regular season.
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Chicago White Sox vs Cleveland Guardians Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
9
|
0.526 | 78 | 41 | 37 |
|
12
|
0.513 | 80 | 41 | 39 |
Chicago White Sox and Cleveland Guardians Latest Matches
3/6 (50%)
3/6 (50%)
Jun 23, 2026 - MLB
Jun 22, 2026 - MLB
Jun 21, 2026 - MLB
Jun 20, 2026 - MLB
Jun 19, 2026 - MLB
Jun 18, 2026 - MLB
5/6 (83%)
1/6 (17%)
Jun 23, 2026 - MLB
Jun 22, 2026 - MLB
Jun 14, 2026 - MLB
Jun 13, 2026 - MLB
Jun 12, 2026 - MLB
Jun 10, 2026 - MLB
1/6 (17%)
5/6 (83%)
Jun 21, 2026 - MLB
Jun 20, 2026 - MLB
Jun 19, 2026 - MLB
Jun 18, 2026 - MLB
Jun 17, 2026 - MLB
Jun 16, 2026 - MLB
2/6 (33%)
4/6 (67%)
Jun 23, 2026 - MLB
Jun 22, 2026 - MLB
Jun 21, 2026 - MLB
Jun 20, 2026 - MLB
Jun 19, 2026 - MLB
Jun 18, 2026 - MLB
2/6 (33%)
4/6 (67%)
Jun 13, 2026 - MLB
Jun 12, 2026 - MLB
Jun 10, 2026 - MLB
Jun 9, 2026 - MLB
Jun 8, 2026 - MLB
May 31, 2026 - MLB
2/6 (33%)
4/6 (67%)
Jun 23, 2026 - MLB
Jun 22, 2026 - MLB
Jun 21, 2026 - MLB
Jun 20, 2026 - MLB
Jun 19, 2026 - MLB
Jun 18, 2026 - MLB
Chicago White Sox against Cleveland Guardians : Head to Head (H2H)
50 %
50 %
Jun 23, 2026 - MLB
Jun 22, 2026 - MLB
Mar 5, 2026 - MLB Spring Training
Feb 28, 2026 - MLB Spring Training
Sep 14, 2025 - MLB
Sep 13, 2025 - MLB
Chicago White Sox - Cleveland Guardians Key Points
- Chicago's last 3 games have all been decided by one run
- Chicago have won 11 of their last 12 games at home
- Cleveland's last 3 games have all been decided by one run
- The Guardians have won just 2 of their last 9 road games
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Our Chicago White Sox vs Cleveland Guardians Prediction
Based on recent contests between the Guardians and White Sox, this seems certain to be a tight matchup that is likely to go down to the wire.
Chicago have (just about) held the upper hand in the first two games of the series, so despite the fact that the Guardians will have the slight edge on the mound for Wednesday's series finale, we are going to take the White Sox on the run line.
Our prediction for Chicago White Sox vs Cleveland Guardians is: White Sox (+1) to win.
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