Chicago White Sox vs Cleveland Guardians Prediction & Picks - MLB
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by Lou Aguila in MLB Picks
7-3 in their last 10 meetings against the Chicago White Sox, the Cleveland Guardians will try to secure a comfortable win in Game 2 of their series at Rate Field.
Current Form:
The Cleveland Guardians have lost their last two games and three of their last four. The Guardians’ offense continues to be decent, averaging 4.2 runs per game over the last five games. However, Cleveland’s ERA has risen to 4.01 over the last five games, up from 3.82 this season.
The Chicago White Sox ended a three-game losing streak with a 6-5 win over the Guardians on June 22. The White Sox sorely missed the power hitting from Munetaka Murakami (10-Day IL, Hamstring) as the offense took a significant hit over the last five games, averaging 3.7 runs per game on a .205 BA.
Starting Pitchers:
Guardians LHP Parker Messick (7-3, 2.70 ERA) surrendered 2 earned runs and 4 hits over six innings in a 4-2 win over Milwaukee on June 18. Messick has registered a 3.21 ERA across his last five starts.
White Sox RHP Sean Burke (4-4, 3.89 ERA) gave up 4 earned runs and 6 hits in a 1-7 loss to LA Dodgers on June 13.
The Matchup: The Guardians have won 7 of their last 10 meetings with the White Sox. Sean Burke has also lost his last three starts vs. Cleveland.
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Chicago White Sox vs Cleveland Guardians Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
9
|
0.526 | 78 | 41 | 37 |
|
12
|
0.513 | 80 | 41 | 39 |
Chicago White Sox and Cleveland Guardians Latest Matches
2/6 (33%)
4/6 (67%)
Jun 22, 2026 - MLB
Jun 21, 2026 - MLB
Jun 20, 2026 - MLB
Jun 19, 2026 - MLB
Jun 18, 2026 - MLB
Jun 17, 2026 - MLB
5/6 (83%)
1/6 (17%)
Jun 22, 2026 - MLB
Jun 14, 2026 - MLB
Jun 13, 2026 - MLB
Jun 12, 2026 - MLB
Jun 10, 2026 - MLB
Jun 9, 2026 - MLB
1/6 (17%)
5/6 (83%)
Jun 21, 2026 - MLB
Jun 20, 2026 - MLB
Jun 19, 2026 - MLB
Jun 18, 2026 - MLB
Jun 17, 2026 - MLB
Jun 16, 2026 - MLB
2/6 (33%)
4/6 (67%)
Jun 22, 2026 - MLB
Jun 21, 2026 - MLB
Jun 20, 2026 - MLB
Jun 19, 2026 - MLB
Jun 18, 2026 - MLB
Jun 17, 2026 - MLB
2/6 (33%)
4/6 (67%)
Jun 13, 2026 - MLB
Jun 12, 2026 - MLB
Jun 10, 2026 - MLB
Jun 9, 2026 - MLB
Jun 8, 2026 - MLB
May 31, 2026 - MLB
2/6 (33%)
4/6 (67%)
Jun 22, 2026 - MLB
Jun 21, 2026 - MLB
Jun 20, 2026 - MLB
Jun 19, 2026 - MLB
Jun 18, 2026 - MLB
Jun 17, 2026 - MLB
Chicago White Sox against Cleveland Guardians : Head to Head (H2H)
33 %
67 %
Jun 22, 2026 - MLB
Mar 5, 2026 - MLB Spring Training
Feb 28, 2026 - MLB Spring Training
Sep 14, 2025 - MLB
Sep 13, 2025 - MLB
Sep 12, 2025 - MLB
Chicago White Sox - Cleveland Guardians Key Points
- Cleveland is 15-3 SU in its last 18 games against Chicago White Sox.
- Chicago White Sox is 2-5 SU in its last 7 games.
- The Guardians have won 7 of their last 10 meetings with the White Sox
- White Sox RHP Sean Burke has also lost his last three starts vs. Cleveland.
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Our Chicago White Sox vs Cleveland Guardians Prediction
Behind Messick's strong start, the Guardians level the series at 1-1 by trouncing the White Sox 7-4
Aside from their 7-3 head-to-head record over Chicago, Cleveland also carries a 15-3 record in its last 18 games against the White Sox.
LHP Parker Messick is in great shape to power the Guardians to another win since he dominated the White Sox in his first-ever start against the club. In that game, Messick allowed one earned run over six innings to give Cleveland a 3-1 win on September 13, 2025.
RHP Sean Burke, who is sporting a 4.62 ERA over his last five starts, has dropped his last three starts against the Guardians.
Cleveland is averaging 7.0 runs per game against right-handed pitchers over the last five games, whereas Chicago is scoring 3.9 runs per game against left-handed pitchers in their last five assignments.
Our betting prediction for the Cleveland Guardians vs. the Chicago White Sox: The Guardians -1.5 Runs.
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