Boston Red Sox vs Cleveland Guardians Prediction & Picks - MLB

Prediction published on 9/2/25, 3:12 PM  by Lou Aguila | Modified on 9/2/25 at 10:44 PM in MLB Picks

The Boston Red Sox seek back-to-back wins over the Cleveland Guardians in Tuesday’s Game 2 at Fenway Park.

The Red Sox, who are 75-64 against the spread this season, pay $100 for every $122 bet if they cover a -1.5-run handicap in this upcoming game.

Current Form:

The Red Sox will try to win their third straight game after beating the Pittsburgh Pirates 5-2 in their series finale and the Guardians 6-4 in Game 1. Boston has been a consistently strong pitching team this season, but their ERA has slightly increased to 4.20 from a season average of 3.80 after surrendering 22 runs in its last five games.

The Guardians are 3-2 in their last five games, but have suffered back-to-back losses to the Mariners 2-4 and the Red Sox 6-4. Cleveland’s offense remains mediocre at best, averaging 3.9 runs per game on a .199 batting average. At 68-68, Cleveland is four games off the current holder of the final wild card spot in the American League, the Seattle Mariners, who carry a 73-65 record.

Boston has topped Cleveland in their last three meetings. The Red Sox have outgunned the Guardians in these three wins, averaging 8.67 runs per game and holding Cleveland to 3.33 runs per contest. Moreover, the Red Sox will dispatch lefty Garrett Crochet, who boasts 3.19 ERA over his last five starts. Cleveland is only hitting .218 with 3.7 runs per game against lefties this season.