Philadelphia 76ers vs Cleveland Cavaliers Prediction & Picks - NBA

USA - NBA

Philadelphia 76ers
10/22/26 19:00
Cleveland Cavaliers

Prediction:

 

The Sixers -3.5 points

−105
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Lou Aguila | in NBA Picks

The Philadelphia 76ers will try to overcome a manageable -3.5 points handicap against the Cleveland Cavaliers on Thursday.

Current Form:

The Cleveland Cavaliers went 1-2 in the preseason, though they have not unleashed their full power in these games. Once again, the Cavaliers will heavily rely on their backcourt duo, Donovan Mitchell and James Harden, while expecting major contributions from big man Evan Mobley.

The reloaded Philadelphia 76ers defeated the defending NBA champion New York Knicks on the day they raised their championship banner. Tyrese Maxey poured in 28 points, and LeBron James posted 14 points, 9 rebounds, and 7 assists for his new team.

The Matchup: The Cavaliers have won 7 of their last 8 games against the Sixers, but this Philadelphia squad is different, with a top-heavy starting five.

Philadelphia 76ers vs Cleveland Cavaliers Form

Table

Teams % P W L Series
1 Philadelphia 76ers
1 1 1 0 1
15 Cleveland Cavaliers
0 0 0 0

Philadelphia 76ers and Cleveland Cavaliers Latest Matches

Philadelphia 76ers
Philadelphia 76ers Latest matches
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 20, 2026 - NBA

New York Knicks
100 :  106
Philadelphia 76ers

Jul 18, 2026 - NBA Summer League

Milwaukee Bucks
96 :  94
Philadelphia 76ers

Jul 15, 2026 - NBA Summer League

Philadelphia 76ers
92 :  99
Orlando Magic

Jul 14, 2026 - NBA Summer League

Houston Rockets
90 :  64
Philadelphia 76ers

Jul 11, 2026 - NBA Summer League

Philadelphia 76ers
100 :  93
Indiana Pacers

Jul 9, 2026 - NBA Summer League

Philadelphia 76ers
101 :  93
Detroit Pistons
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 15, 2026 - NBA Summer League

Philadelphia 76ers
92 :  99
Orlando Magic

Jul 11, 2026 - NBA Summer League

Philadelphia 76ers
100 :  93
Indiana Pacers

Jul 9, 2026 - NBA Summer League

Philadelphia 76ers
101 :  93
Detroit Pistons

May 10, 2026 - NBA

Philadelphia 76ers
114 :  144
New York Knicks

May 8, 2026 - NBA

Philadelphia 76ers
94 :  108
New York Knicks

Apr 30, 2026 - NBA

Philadelphia 76ers
106 :  93
Boston Celtics
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 20, 2026 - NBA

New York Knicks
100 :  106
Philadelphia 76ers

Jul 18, 2026 - NBA Summer League

Milwaukee Bucks
96 :  94
Philadelphia 76ers

Jul 14, 2026 - NBA Summer League

Houston Rockets
90 :  64
Philadelphia 76ers

May 6, 2026 - NBA

New York Knicks
108 :  102
Philadelphia 76ers

May 4, 2026 - NBA

New York Knicks
137 :  98
Philadelphia 76ers

May 2, 2026 - NBA

Boston Celtics
100 :  109
Philadelphia 76ers
Cleveland Cavaliers
Cleveland Cavaliers Latest matches
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 17, 2026 - NBA Summer League

Cleveland Cavaliers
100 :  91
Chicago Bulls

Jul 15, 2026 - NBA Summer League

Cleveland Cavaliers
82 :  77
New Orleans Pelicans

Jul 13, 2026 - NBA Summer League

Cleveland Cavaliers
90 :  73
Miami Heat

Jul 12, 2026 - NBA Summer League

Detroit Pistons
103 :  94
Cleveland Cavaliers

Jul 10, 2026 - NBA Summer League

Indiana Pacers
99 :  93
Cleveland Cavaliers

May 25, 2026 - NBA

Cleveland Cavaliers
93 :  130
New York Knicks
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 17, 2026 - NBA Summer League

Cleveland Cavaliers
100 :  91
Chicago Bulls

Jul 15, 2026 - NBA Summer League

Cleveland Cavaliers
82 :  77
New Orleans Pelicans

Jul 13, 2026 - NBA Summer League

Cleveland Cavaliers
90 :  73
Miami Heat

May 25, 2026 - NBA

Cleveland Cavaliers
93 :  130
New York Knicks

May 23, 2026 - NBA

Cleveland Cavaliers
108 :  121
New York Knicks

May 15, 2026 - NBA

Cleveland Cavaliers
94 :  115
Detroit Pistons
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 12, 2026 - NBA Summer League

Detroit Pistons
103 :  94
Cleveland Cavaliers

Jul 10, 2026 - NBA Summer League

Indiana Pacers
99 :  93
Cleveland Cavaliers

May 21, 2026 - NBA

New York Knicks
109 :  93
Cleveland Cavaliers

May 19, 2026 - NBA

New York Knicks
115 :  104
Cleveland Cavaliers

May 17, 2026 - NBA

Detroit Pistons
94 :  125
Cleveland Cavaliers

May 13, 2026 - NBA

Detroit Pistons
113 :  117
Cleveland Cavaliers

Philadelphia 76ers against Cleveland Cavaliers : Head to Head (H2H)

Philadelphia 76ers

17 %

Cleveland Cavaliers

83 %

Mar 9, 2026 - NBA

Cleveland Cavaliers
115 :  101
Philadelphia 76ers

Jan 16, 2026 - NBA

Philadelphia 76ers
115 :  117
Cleveland Cavaliers

Jan 14, 2026 - NBA

Philadelphia 76ers
107 :  133
Cleveland Cavaliers

Nov 5, 2025 - NBA

Cleveland Cavaliers
132 :  121
Philadelphia 76ers

Jan 24, 2025 - NBA

Philadelphia 76ers
132 :  129
Cleveland Cavaliers

Dec 21, 2024 - NBA

Cleveland Cavaliers
126 :  99
Philadelphia 76ers
Philadelphia 76ers vs Cleveland Cavaliers Picks

Players list

Philadelphia 76ers
Philadelphia 76ers
J. Brown J. Embiid

T. Maxey

V. Edgecombe

L. James

Cleveland Cavaliers
Cleveland Cavaliers
E. Udeh

J. Robinson

M. Thomas

M. Branham

R. Minix

Substitutes

Philadelphia 76ers
Philadelphia 76ers
A. Bona R. Rupert

K. Caldwell-Pope

A. Simons

C. Love

J. Edwards

L. Philon

J. Walker

Cleveland Cavaliers
Cleveland Cavaliers

D. Goodwin

S. East II

I. Martinez

X. Lee

R. Agee

T. Spillers

Philadelphia 76ers - Cleveland Cavaliers Key Points

  1. The Philadelphia 76ers won their first game against the New York Knicks.
  2. The Philadelphia 76ers are 6-4 against the spread in their last 10 games.
  3. The Cleveland Cavaliers will play their first game of the season.
  4. The Cleveland Cavaliers are 4-6 against the spread in their last 10 games.

Our Philadelphia 76ers vs Cleveland Cavaliers Prediction

The Difference Maker: The Sixers just defeated the defending champs on opening night. LeBron James looked good at 41, while Tyrese Maxey and Jaylen Brown are deadly together.

What to Expect: The Cavaliers have the offensive weapons to match the Sixers. However, Philadelphia is more than just a scoring juggernaut. They can also play elite defense, as they did on opening night, holding the Knicks to 100 points. It will take a big game from James Harden and Donovan Mitchell to pull off an upset here, but the Sixers are just too good on paper.

Fearless Forecast: Cavs 103, Sixers 110

Our betting prediction for the Cleveland Cavaliers vs. the Philadelphia 76ers: The Sixers -3.5 points

Prediction:

 

The Sixers -3.5 points

−105
$200 offered for betting!

A Welcome Bonus for Philadelphia 76ers vs Cleveland Cavaliers!

DraftKings Welcome Bonus 200

Looking to place a bet on Philadelphia 76ers vs Cleveland Cavaliers? For this NBA match, DraftKings will treat you to an exclusive offer: $200 in bonus bets, no promo code needed! Take advantage while you still can!

$200 in bonus bets for Philadelphia 76ers vs Cleveland Cavaliers!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.