New York Knicks vs Cleveland Cavaliers Prediction & Picks - NBA

USA - NBA

New York Knicks
10/22/25 19:00
Cleveland Cavaliers

Prediction:

 

Cleveland Cavaliers +2.5

-110
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 by Matt Lowrimore | in NBA Picks

The NBA is finally back, and a full slate of games is scheduled for Wednesday night, including a matchup between the New York Knicks and the Cleveland Cavaliers. Let’s take a look at the match statistics and predictions for this game between the Knicks and the Cavaliers.

Cleveland enters this game having finished 64-18 last season and was first in the Eastern Conference. The Cavaliers advanced to the Eastern Conference Semifinals before losing to the Indiana Pacers in five games. Cleveland still has a strong lineup, led by Donovan Mitchell, who averaged 24.0 points per game last season. 

As for New York, they enter this game having finished 51-31 last season and were third in the Eastern Conference. The Knicks advanced to the Eastern Conference Finals before losing to the Indiana Pacers in six games. New York also still boasts a strong lineup, led by Jalen Brunson, who averaged 26.0 points per game last season.

New York Knicks vs Cleveland Cavaliers Form

Table

Teams % P W L Series
6 New York Knicks
0.646 82 53 29
8 Cleveland Cavaliers
0.634 82 52 30 1

New York Knicks and Cleveland Cavaliers Latest Matches

New York Knicks
New York Knicks Latest matches
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 17, 2025 - NBA Summer League

New York Knicks
88 :  91
Indiana Pacers

Jul 13, 2025 - NBA Summer League

Boston Celtics
94 :  81
New York Knicks

May 31, 2025 - NBA

Indiana Pacers
125 :  108
New York Knicks

May 29, 2025 - NBA

New York Knicks
111 :  94
Indiana Pacers

May 27, 2025 - NBA

Indiana Pacers
130 :  121
New York Knicks

May 25, 2025 - NBA

Indiana Pacers
100 :  106
New York Knicks
W W L L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 17, 2025 - NBA Summer League

New York Knicks
88 :  91
Indiana Pacers

May 29, 2025 - NBA

New York Knicks
111 :  94
Indiana Pacers

May 23, 2025 - NBA

New York Knicks
109 :  114
Indiana Pacers

May 21, 2025 - NBA

New York Knicks
135 :  138
Indiana Pacers

May 16, 2025 - NBA

New York Knicks
119 :  81
Boston Celtics

May 12, 2025 - NBA

New York Knicks
121 :  113
Boston Celtics
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 13, 2025 - NBA Summer League

Boston Celtics
94 :  81
New York Knicks

May 31, 2025 - NBA

Indiana Pacers
125 :  108
New York Knicks

May 27, 2025 - NBA

Indiana Pacers
130 :  121
New York Knicks

May 25, 2025 - NBA

Indiana Pacers
100 :  106
New York Knicks

May 14, 2025 - NBA

Boston Celtics
127 :  102
New York Knicks

May 7, 2025 - NBA

Boston Celtics
90 :  91
New York Knicks
Cleveland Cavaliers
Cleveland Cavaliers Latest matches
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Jul 16, 2025 - NBA Summer League

Cleveland Cavaliers
86 :  94
Sacramento Kings

Jul 10, 2025 - NBA Summer League

Indiana Pacers
116 :  115
Cleveland Cavaliers

May 13, 2025 - NBA

Cleveland Cavaliers
105 :  114
Indiana Pacers

May 11, 2025 - NBA

Indiana Pacers
129 :  109
Cleveland Cavaliers

May 9, 2025 - NBA

Indiana Pacers
104 :  126
Cleveland Cavaliers

May 6, 2025 - NBA

Cleveland Cavaliers
119 :  120
Indiana Pacers
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 16, 2025 - NBA Summer League

Cleveland Cavaliers
86 :  94
Sacramento Kings

May 13, 2025 - NBA

Cleveland Cavaliers
105 :  114
Indiana Pacers

May 6, 2025 - NBA

Cleveland Cavaliers
119 :  120
Indiana Pacers

May 4, 2025 - NBA

Cleveland Cavaliers
112 :  121
Indiana Pacers

Apr 23, 2025 - NBA

Cleveland Cavaliers
121 :  112
Miami Heat

Apr 20, 2025 - NBA

Cleveland Cavaliers
121 :  100
Miami Heat
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jul 10, 2025 - NBA Summer League

Indiana Pacers
116 :  115
Cleveland Cavaliers

May 11, 2025 - NBA

Indiana Pacers
129 :  109
Cleveland Cavaliers

May 9, 2025 - NBA

Indiana Pacers
104 :  126
Cleveland Cavaliers

Apr 28, 2025 - NBA

Miami Heat
83 :  138
Cleveland Cavaliers

Apr 26, 2025 - NBA

Miami Heat
87 :  124
Cleveland Cavaliers

Apr 11, 2025 - NBA

New York Knicks
102 :  108
Cleveland Cavaliers

New York Knicks against Cleveland Cavaliers : Head to Head (H2H)

New York Knicks

17 %

Cleveland Cavaliers

83 %

Apr 11, 2025 - NBA

New York Knicks
102 :  108
Cleveland Cavaliers

Apr 2, 2025 - NBA

Cleveland Cavaliers
124 :  105
New York Knicks

Feb 21, 2025 - NBA

Cleveland Cavaliers
142 :  105
New York Knicks

Oct 28, 2024 - NBA

New York Knicks
104 :  110
Cleveland Cavaliers

Mar 3, 2024 - NBA

Cleveland Cavaliers
98 :  107
New York Knicks

Nov 1, 2023 - NBA

New York Knicks
89 :  95
Cleveland Cavaliers
New York Knicks vs Cleveland Cavaliers Picks

Players list

New York Knicks
New York Knicks
A. Hukporti

J. Brunson

M. Bridges

K. Towns

O. Anunoby

Cleveland Cavaliers
Cleveland Cavaliers
J. Allen

D. Mitchell

S. Merrill

E. Mobley

J. Tyson

Substitutes

New York Knicks
New York Knicks
T. Jemison

J. Clarkson

M. McBride

T. Kolek

L. Shamet

M. Diawara

P. Dadiet

G. Yabusele

Cleveland Cavaliers
Cleveland Cavaliers
D. Wade L. Nance Jr. T. Bryant

L. Travers

C. Porter

L. Ball

T. Proctor

N. Tomlin

New York Knicks - Cleveland Cavaliers Key Points

  1. Cleveland’s Darius Garland is OUT
  2. Cleveland’s De’Andre Hunter is a Game-Time Decision
  3. New York’s Karl-Anthony Towns is a Game-Time Decision
  4. New York’s OG Anunoby is a Game-Time Decision

Our New York Knicks vs Cleveland Cavaliers Prediction

Cleveland is the short underdog in this game, but looks to be a solid betting option. The Cavaliers are dealing with some injuries to start the season, that being De’Andre Hunter and Darius Garland.

That said, New York is also dealing with some injuries, that being OG Anunoby and Karl-Anthony Towns, among a few others. 

The Cavaliers swept the Knicks in the regular season last year, winning these four games by an average margin of 17 points per game.

The start of a new season can always take time for teams to get up to speed; however, because the Cavs dominated the Knicks in their recent meetings, our New York Knicks vs Cleveland Cavaliers prediction is: Cleveland Cavaliers +2.5.

Prediction:

 

Cleveland Cavaliers +2.5

-110
$150 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.