Detroit Lions vs Cleveland Browns Prediction & Picks - NFL

USA - NFL

Detroit Lions
9/28/25 13:00
Cleveland Browns

Prediction:

 

Lions -9.5

-115
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 by Travis Pulver | in NFL Picks

The Lions will go for their third win of the young season Sunday, September 28, when they host the Cleveland Browns at Ford Field in Detroit, MI. Kickoff for this interconference matchup is scheduled for 1 p.m. EST, and the game will be broadcast on Fox.

Any concerns that arose after their Week 1 loss have disappeared with how the Lions have bounced back since then. They demolished the Chicago Bears, 52-21, beating them in just about every facet of the game. Last week, they went into Baltimore as 4.5-point underdogs and shut down the Ravens' run game while running for 224 yards and four touchdowns. Of course, it will not be easy to run the ball on the Browns' defensive front, led by Myles Garrett. Through Week 3, the Browns rank No. 1 in total defense (204.3 yards per game allowed) and first against the run (57.3 yards per game allowed). However, the Lions do have a top-ten offensive line, according to PFF. But even if the Browns' defense can step up to the plate, they can’t expect to get much help from the offensive side of the ball. With Joe Flacco at quarterback, the Browns offense is averaging 15.3 points per game (No. 30).

Detroit Lions vs Cleveland Browns Form

Table

Teams Pts P W L
15 Detroit Lions
0.529 17 9 8
27 Cleveland Browns
0.294 17 5 12

Detroit Lions and Cleveland Browns Latest Matches

Detroit Lions
Detroit Lions Latest matches
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 22, 2025 - NFL

Baltimore Ravens
30 :  38
Detroit Lions

Sep 14, 2025 - NFL

Detroit Lions
52 :  21
Chicago Bears

Sep 7, 2025 - NFL

Green Bay Packers
27 :  13
Detroit Lions

Jan 18, 2025 - NFL

Detroit Lions
31 :  45
Washington Commanders

Jan 5, 2025 - NFL

Detroit Lions
31 :  9
Minnesota Vikings

Dec 30, 2024 - NFL

San Francisco 49ers
34 :  40
Detroit Lions
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 14, 2025 - NFL

Detroit Lions
52 :  21
Chicago Bears

Jan 18, 2025 - NFL

Detroit Lions
31 :  45
Washington Commanders

Jan 5, 2025 - NFL

Detroit Lions
31 :  9
Minnesota Vikings

Dec 15, 2024 - NFL

Detroit Lions
42 :  48
Buffalo Bills

Dec 5, 2024 - NFL

Detroit Lions
34 :  31
Green Bay Packers

Nov 28, 2024 - NFL

Detroit Lions
23 :  20
Chicago Bears
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 22, 2025 - NFL

Baltimore Ravens
30 :  38
Detroit Lions

Sep 7, 2025 - NFL

Green Bay Packers
27 :  13
Detroit Lions

Dec 30, 2024 - NFL

San Francisco 49ers
34 :  40
Detroit Lions

Dec 22, 2024 - NFL

Chicago Bears
17 :  34
Detroit Lions

Nov 24, 2024 - NFL

Indianapolis Colts
6 :  24
Detroit Lions

Nov 10, 2024 - NFL

Houston Texans
23 :  26
Detroit Lions
Cleveland Browns
Cleveland Browns Latest matches
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 21, 2025 - NFL

Cleveland Browns
13 :  10
Green Bay Packers

Sep 14, 2025 - NFL

Baltimore Ravens
41 :  17
Cleveland Browns

Sep 7, 2025 - NFL

Cleveland Browns
16 :  17
Cincinnati Bengals

Jan 4, 2025 - NFL

Baltimore Ravens
35 :  10
Cleveland Browns

Dec 29, 2024 - NFL

Cleveland Browns
3 :  20
Miami Dolphins

Dec 22, 2024 - NFL

Cincinnati Bengals
24 :  6
Cleveland Browns
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 21, 2025 - NFL

Cleveland Browns
13 :  10
Green Bay Packers

Sep 7, 2025 - NFL

Cleveland Browns
16 :  17
Cincinnati Bengals

Dec 29, 2024 - NFL

Cleveland Browns
3 :  20
Miami Dolphins

Dec 15, 2024 - NFL

Cleveland Browns
7 :  21
Kansas City Chiefs

Nov 21, 2024 - NFL

Cleveland Browns
24 :  19
Pittsburgh Steelers

Oct 27, 2024 - NFL

Cleveland Browns
29 :  24
Baltimore Ravens
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 14, 2025 - NFL

Baltimore Ravens
41 :  17
Cleveland Browns

Jan 4, 2025 - NFL

Baltimore Ravens
35 :  10
Cleveland Browns

Dec 22, 2024 - NFL

Cincinnati Bengals
24 :  6
Cleveland Browns

Dec 8, 2024 - NFL

Pittsburgh Steelers
27 :  14
Cleveland Browns

Dec 2, 2024 - NFL

Denver Broncos
41 :  32
Cleveland Browns

Nov 17, 2024 - NFL

New Orleans Saints
35 :  14
Cleveland Browns

Detroit Lions - Cleveland Browns Key Points

  1. The Lions lead the all-time series vs. the Browns 19-6.
  2. Detroit and Cleveland last played during the 2021 season (November 21, 2021), a game the Browns won 13-10.
  3. Betting Public: 70% of spread tickets are on the Browns (+10), but only 45% of the handle.
  4. Betting Pubic: 60% of TOTAL tickets and 68% of the handle are on the UNDER.

Our Detroit Lions vs Cleveland Browns Prediction

You almost have to feel a little sorry for the Browns defense. With a unit playing as well as they are, they should be undefeated and making the postseason. But with one of the worst offenses in the league…The question here is not whether the Lions will win this game, because they should, but whether they’ll cover. With 70% of tickets on the Browns' spread, it appears that the public is backing the Browns. While they have played well, this game will be similar to the Baltimore game in Week 2; the game was close at halftime with the Ravens up 10-3. But then Baltimore turned it on in the second half, scoring 31 points.

Our Browns vs. Lions Pick: Lions -9.5

Prediction:

 

Lions -9.5

-115
$350 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Detroit Lions vs Cleveland Browns Picks