Tampa Bay Rays vs Cincinnati Reds Prediction & Picks - MLB

USA - MLB

Tampa Bay Rays
4/21/26 18:40
Cincinnati Reds

Prediction:

 

The Reds -1.5 Runs

+150
$250 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Lou Aguila | in MLB Picks

The Cincinnati Reds have won by at least two runs in 3 of their last 5 wins over the Tampa Bay Rays.

by one of the best bullpens (2.23 ERA) in baseball this season, the Reds target another lucrative ATS win (+150 at -1.5 runs) against the Rays in Game 2 of their series on Tuesday.

Momentum: The Cincinnati Reds drew first blood against the Tampa Bay Rays 6-1 in Game 1 to secure their fourth consecutive victory and improve their record to 15-8. The Rays, on the other hand, have lost three of their last four games. Tampa Bay still carries a 12-10 record, but they need to win their next ballgame to avoid plunging below .500.

The Matchup: This is the first and only meeting between the Reds and Rays in a three-game interleague series. Cincinnati already took Game 1, 6-1, as Rhett Lowder surrendered one earned run over six innings and rookie Sal Stewart drove in two runs.

Starting Pitchers: Reds RHP Chase Burns (1-1, 2.42 ERA) vs. Rays LHP Steven Matz (3-0, 3.80 ERA)

Hot on the Board: Bookmakers have not installed a favorite for Game 2 of this series, listing the Reds and the Rays at -110 moneyline. The Reds are +150 on the 1.5-run line, and the Rays are -178 with a +1.5-run advantage on the spread.

Up to $250 to bet on Tampa Bay Rays - Cincinnati Reds! 

Limited Offer. Currently at Caesars Sportsbook

Tampa Bay Rays vs Cincinnati Reds Form

Table

Teams Pts P W L
4 Tampa Bay Rays
0.588 80 47 33
20 Cincinnati Reds
0.481 81 39 42

Tampa Bay Rays and Cincinnati Reds Latest Matches

Tampa Bay Rays
Tampa Bay Rays Latest matches
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 20, 2026 - MLB

Tampa Bay Rays
1 :  6
Cincinnati Reds

Apr 19, 2026 - MLB

Pittsburgh Pirates
6 :  3
Tampa Bay Rays

Apr 18, 2026 - MLB

Pittsburgh Pirates
7 :  8
Tampa Bay Rays

Apr 17, 2026 - MLB

Pittsburgh Pirates
5 :  1
Tampa Bay Rays

Apr 16, 2026 - MLB

Chicago White Sox
3 :  5
Tampa Bay Rays

Apr 15, 2026 - MLB

Chicago White Sox
3 :  8
Tampa Bay Rays
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 20, 2026 - MLB

Tampa Bay Rays
1 :  6
Cincinnati Reds

Apr 12, 2026 - MLB

Tampa Bay Rays
5 :  4
New York Yankees

Apr 11, 2026 - MLB

Tampa Bay Rays
5 :  4
New York Yankees

Apr 10, 2026 - MLB

Tampa Bay Rays
5 :  3
New York Yankees

Apr 8, 2026 - MLB

Tampa Bay Rays
2 :  6
Chicago Cubs

Apr 7, 2026 - MLB

Tampa Bay Rays
2 :  9
Chicago Cubs
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 19, 2026 - MLB

Pittsburgh Pirates
6 :  3
Tampa Bay Rays

Apr 18, 2026 - MLB

Pittsburgh Pirates
7 :  8
Tampa Bay Rays

Apr 17, 2026 - MLB

Pittsburgh Pirates
5 :  1
Tampa Bay Rays

Apr 16, 2026 - MLB

Chicago White Sox
3 :  5
Tampa Bay Rays

Apr 15, 2026 - MLB

Chicago White Sox
3 :  8
Tampa Bay Rays

Apr 14, 2026 - MLB

Chicago White Sox
5 :  8
Tampa Bay Rays
Cincinnati Reds
Cincinnati Reds Latest matches
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 20, 2026 - MLB

Tampa Bay Rays
1 :  6
Cincinnati Reds

Apr 19, 2026 - MLB

Minnesota Twins
4 :  7
Cincinnati Reds

Apr 18, 2026 - MLB

Minnesota Twins
4 :  5
Cincinnati Reds

Apr 17, 2026 - MLB

Minnesota Twins
1 :  2
Cincinnati Reds

Apr 16, 2026 - MLB

Cincinnati Reds
0 :  3
San Francisco Giants

Apr 15, 2026 - MLB

Cincinnati Reds
8 :  3
San Francisco Giants
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 16, 2026 - MLB

Cincinnati Reds
0 :  3
San Francisco Giants

Apr 15, 2026 - MLB

Cincinnati Reds
8 :  3
San Francisco Giants

Apr 14, 2026 - MLB

Cincinnati Reds
2 :  1
San Francisco Giants

Apr 12, 2026 - MLB

Cincinnati Reds
6 :  9
Los Angeles Angels

Apr 11, 2026 - MLB

Cincinnati Reds
7 :  3
Los Angeles Angels

Apr 10, 2026 - MLB

Cincinnati Reds
2 :  10
Los Angeles Angels
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 20, 2026 - MLB

Tampa Bay Rays
1 :  6
Cincinnati Reds

Apr 19, 2026 - MLB

Minnesota Twins
4 :  7
Cincinnati Reds

Apr 18, 2026 - MLB

Minnesota Twins
4 :  5
Cincinnati Reds

Apr 17, 2026 - MLB

Minnesota Twins
1 :  2
Cincinnati Reds

Apr 9, 2026 - MLB

Miami Marlins
8 :  1
Cincinnati Reds

Apr 8, 2026 - MLB

Miami Marlins
7 :  4
Cincinnati Reds

Tampa Bay Rays against Cincinnati Reds : Head to Head (H2H)

Tampa Bay Rays

33 %

Cincinnati Reds

67 %

Apr 20, 2026 - MLB

Tampa Bay Rays
1 :  6
Cincinnati Reds

Jul 27, 2025 - MLB

Cincinnati Reds
2 :  1
Tampa Bay Rays

Jul 26, 2025 - MLB

Cincinnati Reds
6 :  2
Tampa Bay Rays

Jul 25, 2025 - MLB

Cincinnati Reds
7 :  2
Tampa Bay Rays

Jul 28, 2024 - MLB

Tampa Bay Rays
2 :  1
Cincinnati Reds

Jul 27, 2024 - MLB

Tampa Bay Rays
4 :  0
Cincinnati Reds

Tampa Bay Rays - Cincinnati Reds Key Points

  1. Cincinnati is 6-1 SU in its last 7 games.
  2. Cincinnati is 9-2 SU in its last 11 games on the road.
  3. Tampa Bay is 1-5 SU in its last 6 games against an opponent in the National League.
  4. Tampa Bay is 1-5 SU in its last 6 games against an opponent in the National League Central Division
Up to $250 to bet on Tampa Bay Rays - Cincinnati Reds! 

Limited Offer. Currently at Caesars Sportsbook

Our Tampa Bay Rays vs Cincinnati Reds Prediction

Fearless Forecast: The Reds maintain dominance of the Rays, win Game 2, 8-4

The Edge: The Reds are 4-0 in their last four and 5-2 in their last seven meetings with the Rays. Of these five wins, the Reds won by at least two runs three times, including Monday’s 6-1 win. On Tuesday, Cincinnati will send right-handed pitcher Connor Burns, who posted his second shutout of the year after throwing scoreless innings in a 3-0 win over the San Francisco Giants on April 16. As for Tampa Bay, the Rays will pin their hopes on Steven Matz, who helped the Rays to a win in all four of his starts this season. Cincinnati is only batting .194 with 2.4 runs per game against lefties this season, so interesting how the Reds will score against a dominant lefty like Matz.

The Bet: I am still riding with the Reds for the simple reason that they have won their last four games against the Rays. Also, Cincinnati’s relief pitchers have been terrific this season with a 2.23 ERA, and the bullpen was also very good in Game 1 when it basically shut the door on Tampa Bay down the stretch. I expect the same things to happen on Tuesday, wherein Burns keeps the Rays hitters in check for at least six innings before the relief pitchers take over again and suck the air out of the home team.

Our betting prediction for the Cincinnati Reds vs. the Tampa Bay Rays: The Reds -1.5 Runs

Prediction:

 

The Reds -1.5 Runs

+150
$250 offered for betting!

Caesars Rewards Program

Caesars Rewards

Caesars Sportsbook really spoils new users with an awesome rewards program, making every wager count towards something bigger! Available for users across the country, this program is a bettor's dream. As you enjoy the thrills of sports betting or casino games online, you can earn up to 10 Reward Credits for every $100 wagered on straight bets. And if parlays are more your style, you'll earn up to 20 Reward Credits for every $100 wagered. With Caesars Sportsbook, your bets not only bring the excitement of the game but also the joy of accumulating rewards that enhance your gaming experience. Play now and let Caesars treat you like royalty with each bet you place!

Sign-up now!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Tampa Bay Rays vs Cincinnati Reds Picks