St. Louis Cardinals vs Cincinnati Reds Prediction & Picks - MLB

Prediction published on 6/21/25, 10:29 AM  by Lou Aguila | Modified on 2/3/26 at 8:51 AM in MLB Picks

The St. Louis Cardinals look to extend their hot streak to five games when they play the Cincinnati Reds in Game 2 of their series on Saturday at Busch Stadium.

After Friday’s 6-1 win over the Reds, the Cardinals have earned four wins in a row behind a productive batting corps and solid pitching from their starters. St. Louis is smoking their competition over their last five games, averaging 6.8 runs per game while pitching a 3.00 ERA. The Cardinals are third in the NL Central with a 41-35, 4.5 games below the 45-30 Chicago Cubs.

The Reds have absorbed their second straight loss after racking up four wins in a row earlier this week. Cincinnati’s offense was non-existent in Friday’s series opener against St. Louis, scoring only one run in 9 innings. The Reds are pitching a 4.83 ERA and averaging 5.3 runs per game over their last five assignments.