Pittsburgh Pirates vs Cincinnati Reds Prediction & Picks - MLB
USA - MLB
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Lou Aguila | in MLB Picks
With the over trending for both teams over the last five games, the over/under 8 runs is looking like a solid play for Game 2 between the Cincinnati Reds and the Pittsburgh Pirates.
Momentum: The Cincinnati Reds are 2-3 in their last five games, losing to the Pittsburgh Pirates 1-9 in the series opener. The Pirates snapped a five-game losing streak with the win on Friday. Cincinnati sits atop the NL Central with a 20-11 record, while Pittsburgh is dead last at 16-16.
The Matchup: The Pirates have won their last three meetings with the Reds and five of their last seven games. Over the last five games, Cincinnati has pitched a 7.16 ERA and averaged 4.0 runs per game. The Pirates have produced 5.5 runs per game and posted a 6.00 ERA over their last five matches.
Starting Pitchers: Reds RHP Rhett Lowder (3-1, 3.18 ERA) vs. Pirates RHP Carmen Mlodzinski (1-2, 4.13 ERA).
Lowder allowed two earned runs over five innings in a 3-8 loss to Detroit on April 26. The last time Lowder faced the Pirates, he threw five scoreless innings in a 7-1 win over Pittsburgh on Sept. 21, 2024. Mlodzinski have given up 9 runs over 7.3 innings in two starts. Last year, Mlodzinski gave up four earned runs over 4.1 innings in a 0-4 loss to Cincinnati.
Limited Offer. Currently at Caesars Sportsbook
Pittsburgh Pirates vs Cincinnati Reds Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
16
|
0.494 | 83 | 41 | 42 |
|
20
|
0.481 | 81 | 39 | 42 |
Pittsburgh Pirates and Cincinnati Reds Latest Matches
1/6 (17%)
5/6 (83%)
May 1, 2026 - MLB
Apr 30, 2026 - MLB
Apr 29, 2026 - MLB
Apr 28, 2026 - MLB
Apr 27, 2026 - MLB
Apr 26, 2026 - MLB
2/6 (33%)
4/6 (67%)
May 1, 2026 - MLB
Apr 30, 2026 - MLB
Apr 29, 2026 - MLB
Apr 28, 2026 - MLB
Apr 27, 2026 - MLB
Apr 19, 2026 - MLB
3/6 (50%)
3/6 (50%)
Apr 26, 2026 - MLB
Apr 25, 2026 - MLB
Apr 24, 2026 - MLB
Apr 23, 2026 - MLB
Apr 22, 2026 - MLB
Apr 21, 2026 - MLB
3/6 (50%)
3/6 (50%)
May 1, 2026 - MLB
Apr 30, 2026 - MLB
Apr 29, 2026 - MLB
Apr 28, 2026 - MLB
Apr 26, 2026 - MLB
Apr 25, 2026 - MLB
4/6 (67%)
2/6 (33%)
Apr 30, 2026 - MLB
Apr 29, 2026 - MLB
Apr 28, 2026 - MLB
Apr 26, 2026 - MLB
Apr 25, 2026 - MLB
Apr 24, 2026 - MLB
4/6 (67%)
2/6 (33%)
May 1, 2026 - MLB
Apr 22, 2026 - MLB
Apr 21, 2026 - MLB
Apr 20, 2026 - MLB
Apr 19, 2026 - MLB
Apr 18, 2026 - MLB
Pittsburgh Pirates against Cincinnati Reds : Head to Head (H2H)
67 %
33 %
May 1, 2026 - MLB
Apr 1, 2026 - MLB
Mar 31, 2026 - MLB
Mar 30, 2026 - MLB
Sep 25, 2025 - MLB
Sep 24, 2025 - MLB
Pittsburgh Pirates - Cincinnati Reds Key Points
- The total has gone OVER in 5 of Pittsburgh's last 6 games.
- The total has gone OVER in 5 of Pittsburgh's last 6 games at home.
- The total has gone OVER in 6 of Cincinnati's last 6 games.
- The total has gone OVER in 4 of Cincinnati's last 5 games against an opponent in the National League.
Limited Offer. Currently at Caesars Sportsbook
Our Pittsburgh Pirates vs Cincinnati Reds Prediction
Back the Over 8.0 runs. The total has gone OVER in 6 of Cincinnati's last 6 games and 4 of Pittsburgh's last 6 games. These teams have averaged a combined 8.0 runs per game over the last three head-to-head meetings. The Reds and the Pirates have also breached the 6.00 ERA territory over their last five games. Cincinnati has posted a 7.16 ERA and the Pirates have pitched a 6.00 ERA over this stretch. This is going to be another high-scoring game with either or both teams scoring at least 7 runs.
Our betting prediction for the Cincinnati Reds vs. the Pittsburgh Pirates: Over 8 runs.Caesars Rewards Program

Caesars Sportsbook really spoils new users with an awesome rewards program, making every wager count towards something bigger! Available for users across the country, this program is a bettor's dream. As you enjoy the thrills of sports betting or casino games online, you can earn up to 10 Reward Credits for every $100 wagered on straight bets. And if parlays are more your style, you'll earn up to 20 Reward Credits for every $100 wagered. With Caesars Sportsbook, your bets not only bring the excitement of the game but also the joy of accumulating rewards that enhance your gaming experience. Play now and let Caesars treat you like royalty with each bet you place!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.