Pittsburgh Pirates vs Cincinnati Reds Prediction & Picks - MLB

USA - MLB

Pittsburgh Pirates
5/21/25 12:35
Cincinnati Reds

Prediction:

 

Reds -1.5 Runs

+135
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 by Lou Aguila | in MLB Picks

The Pittsburgh Pirates and the Cincinnati Reds will try to settle the score on Wednesday in Game 3 of their series at PNC Park.

The Pirates ended their four-game win drought with a 1-0 win over the Reds on Tuesday. Bailey Falter pitched through seven scoreless innings with 5 strikeouts while Bryan Reynolds drove the game-winning run in the 6th inning. Pittsburgh captured only their 16th win of the season, and they are still last in the NL Central with a 16-33 record.

The Reds’ five-game may have come to an end but that recent win streak has elevated the record to .500 with a 25-25 record, third in the NL Central. Cincinnati continues to wreak havoc on the mound this season, pitching a 3.49 ERA and 1.16 WHIP. The Reds haven’t surrendered more than 1 run in each of their last 4 matches.

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Pittsburgh Pirates vs Cincinnati Reds Form

Table

Teams Pts P W L
13 Cincinnati Reds
0.512 162 83 79
26 Pittsburgh Pirates
0.438 162 71 91

Pittsburgh Pirates and Cincinnati Reds Latest Matches

Pittsburgh Pirates
Pittsburgh Pirates Latest matches
W L L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 18, 2025 - MLB

Philadelphia Phillies
1 :  0
Pittsburgh Pirates

May 17, 2025 - MLB

Philadelphia Phillies
5 :  2
Pittsburgh Pirates

May 14, 2025 - MLB

New York Mets
0 :  4
Pittsburgh Pirates

May 13, 2025 - MLB

New York Mets
2 :  1
Pittsburgh Pirates

May 12, 2025 - MLB

New York Mets
4 :  3
Pittsburgh Pirates

May 11, 2025 - MLB

Pittsburgh Pirates
4 :  3
Atlanta Braves
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 11, 2025 - MLB

Pittsburgh Pirates
4 :  3
Atlanta Braves

May 10, 2025 - MLB

Pittsburgh Pirates
2 :  3
Atlanta Braves

May 9, 2025 - MLB

Pittsburgh Pirates
3 :  2
Atlanta Braves

May 4, 2025 - MLB

Pittsburgh Pirates
0 :  4
San Diego Padres

May 3, 2025 - MLB

Pittsburgh Pirates
1 :  2
San Diego Padres

May 2, 2025 - MLB

Pittsburgh Pirates
4 :  9
San Diego Padres
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

May 18, 2025 - MLB

Philadelphia Phillies
1 :  0
Pittsburgh Pirates

May 17, 2025 - MLB

Philadelphia Phillies
5 :  2
Pittsburgh Pirates

May 14, 2025 - MLB

New York Mets
0 :  4
Pittsburgh Pirates

May 13, 2025 - MLB

New York Mets
2 :  1
Pittsburgh Pirates

May 12, 2025 - MLB

New York Mets
4 :  3
Pittsburgh Pirates

May 7, 2025 - MLB

St. Louis Cardinals
5 :  0
Pittsburgh Pirates
Cincinnati Reds
Cincinnati Reds Latest matches
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 15, 2025 - MLB

Cincinnati Reds
7 :  1
Chicago White Sox

May 11, 2025 - MLB

Houston Astros
6 :  0
Cincinnati Reds

May 8, 2025 - MLB

Atlanta Braves
5 :  4
Cincinnati Reds

May 7, 2025 - MLB

Atlanta Braves
3 :  4
Cincinnati Reds

May 6, 2025 - MLB

Atlanta Braves
2 :  1
Cincinnati Reds

May 4, 2025 - MLB

Cincinnati Reds
1 :  4
Washington Nationals
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 15, 2025 - MLB

Cincinnati Reds
7 :  1
Chicago White Sox

May 4, 2025 - MLB

Cincinnati Reds
1 :  4
Washington Nationals

May 3, 2025 - MLB

Cincinnati Reds
6 :  11
Washington Nationals

May 2, 2025 - MLB

Cincinnati Reds
6 :  1
Washington Nationals

May 1, 2025 - MLB

Cincinnati Reds
9 :  1
St. Louis Cardinals

Apr 30, 2025 - MLB

Cincinnati Reds
1 :  9
St. Louis Cardinals
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 11, 2025 - MLB

Houston Astros
6 :  0
Cincinnati Reds

May 8, 2025 - MLB

Atlanta Braves
5 :  4
Cincinnati Reds

May 7, 2025 - MLB

Atlanta Braves
3 :  4
Cincinnati Reds

May 6, 2025 - MLB

Atlanta Braves
2 :  1
Cincinnati Reds

Apr 26, 2025 - MLB

Colorado Rockies
4 :  6
Cincinnati Reds

Apr 22, 2025 - MLB

Miami Marlins
4 :  3
Cincinnati Reds

Pittsburgh Pirates against Cincinnati Reds : Head to Head (H2H)

Pittsburgh Pirates

17 %

Cincinnati Reds

83 %

Apr 13, 2025 - MLB

Cincinnati Reds
4 :  0
Pittsburgh Pirates

Apr 12, 2025 - MLB

Cincinnati Reds
5 :  2
Pittsburgh Pirates

Apr 11, 2025 - MLB

Cincinnati Reds
5 :  3
Pittsburgh Pirates

Sep 21, 2024 - MLB

Cincinnati Reds
7 :  1
Pittsburgh Pirates

Sep 20, 2024 - MLB

Cincinnati Reds
8 :  3
Pittsburgh Pirates

Aug 23, 2024 - MLB

Pittsburgh Pirates
6 :  5
Cincinnati Reds

Pittsburgh Pirates - Cincinnati Reds Key Points

  1. Cincinnati is 5-1 SU in its last 6 games.
  2. Cincinnati is 4-1 SU in its last 5 games against Pittsburgh.
  3. Pittsburgh is 1-4 SU in its last 5 games.
  4. Pittsburgh is 14-5 SU in its last 19 games when playing at home against Cincinnati.
Up to $250 to bet on Pittsburgh Pirates - Cincinnati Reds! 

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Our Pittsburgh Pirates vs Cincinnati Reds Prediction

Fearless Forecast: Reds takes series with another rout over the Pirates

Why we should bet on the Reds to cover -1.5 runs: I honestly think Tuesday night’s loss to the Pirates was a fluke. Therefore, I am expecting a stronger and meaner fightback from Cincinnati in the series finale on Tuesday. The Reds are averaging 4.1 runs per game on a .280 BA and pitching a gaudy 1.64 ERA over their last 5 assignments. Pirates starter Andrew Heaney, who lost his last 4 starts, will need to step up his game if he doesn’t want to get obliterated by the Reds, who boasts the 9th highest total run in the MLB at 227.

Our betting prediction for Cincinnati Reds vs. Pittsburgh Pirates: Reds -1.5 Runs

Prediction:

 

Reds -1.5 Runs

+135
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Pittsburgh Pirates vs Cincinnati Reds Picks