Minnesota Twins vs Cincinnati Reds Prediction & Picks - MLB

USA - MLB

Minnesota Twins
4/17/26 20:10
Cincinnati Reds

Prediction:

 

Minnesota Twins ML

-175
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 by Matt Lowrimore | in MLB Picks

A full 15-game slate is scheduled in the MLB on Friday, and will include an interleague matchup between the Minnesota Twins and the Cincinnati Reds. Let’s take a look at the match statistics and predictions for this game between the Twins and the Reds.

Cincinnati is coming off a loss on Thursday, but still won the three-game series against the San Francisco Giants. The Reds are now set to start Brandon Williamson in Game 1 of this series against the Twins. Williamson is 1-1 on the season and has an ERA of 5.28. Through three starts, he has allowed nine earned runs over 15.1 innings. 

Coming off an off-day on Thursday, Minnesota is set to counter with Joe Ryan in Game 1 of this series. He enters this game with a record of 2-1 on the season and has an ERA of 3.80. Through his four starts, he has allowed nine earned runs over 21.1 innings.

Minnesota Twins vs Cincinnati Reds Form

Table

Teams Pts P W L
15 Cincinnati Reds
0.508 61 31 30
22 Minnesota Twins
0.453 64 29 35

Minnesota Twins and Cincinnati Reds Latest Matches

Minnesota Twins
Minnesota Twins Latest matches
L W W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 15, 2026 - MLB

Minnesota Twins
5 :  9
Boston Red Sox

Apr 14, 2026 - MLB

Minnesota Twins
6 :  0
Boston Red Sox

Apr 13, 2026 - MLB

Minnesota Twins
13 :  6
Boston Red Sox

Apr 12, 2026 - MLB

Toronto Blue Jays
2 :  8
Minnesota Twins

Apr 11, 2026 - MLB

Toronto Blue Jays
4 :  7
Minnesota Twins

Apr 10, 2026 - MLB

Toronto Blue Jays
10 :  4
Minnesota Twins
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 15, 2026 - MLB

Minnesota Twins
5 :  9
Boston Red Sox

Apr 14, 2026 - MLB

Minnesota Twins
6 :  0
Boston Red Sox

Apr 13, 2026 - MLB

Minnesota Twins
13 :  6
Boston Red Sox

Apr 9, 2026 - MLB

Minnesota Twins
3 :  1
Detroit Tigers

Apr 8, 2026 - MLB

Minnesota Twins
8 :  6
Detroit Tigers

Apr 7, 2026 - MLB

Minnesota Twins
4 :  2
Detroit Tigers
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 12, 2026 - MLB

Toronto Blue Jays
2 :  8
Minnesota Twins

Apr 11, 2026 - MLB

Toronto Blue Jays
4 :  7
Minnesota Twins

Apr 10, 2026 - MLB

Toronto Blue Jays
10 :  4
Minnesota Twins

Apr 2, 2026 - MLB

Kansas City Royals
1 :  5
Minnesota Twins

Apr 1, 2026 - MLB

Kansas City Royals
13 :  9
Minnesota Twins

Mar 30, 2026 - MLB

Kansas City Royals
3 :  1
Minnesota Twins
Cincinnati Reds
Cincinnati Reds Latest matches
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 16, 2026 - MLB

Cincinnati Reds
0 :  3
San Francisco Giants

Apr 15, 2026 - MLB

Cincinnati Reds
8 :  3
San Francisco Giants

Apr 14, 2026 - MLB

Cincinnati Reds
2 :  1
San Francisco Giants

Apr 12, 2026 - MLB

Cincinnati Reds
6 :  9
Los Angeles Angels

Apr 11, 2026 - MLB

Cincinnati Reds
7 :  3
Los Angeles Angels

Apr 10, 2026 - MLB

Cincinnati Reds
2 :  10
Los Angeles Angels
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 16, 2026 - MLB

Cincinnati Reds
0 :  3
San Francisco Giants

Apr 15, 2026 - MLB

Cincinnati Reds
8 :  3
San Francisco Giants

Apr 14, 2026 - MLB

Cincinnati Reds
2 :  1
San Francisco Giants

Apr 12, 2026 - MLB

Cincinnati Reds
6 :  9
Los Angeles Angels

Apr 11, 2026 - MLB

Cincinnati Reds
7 :  3
Los Angeles Angels

Apr 10, 2026 - MLB

Cincinnati Reds
2 :  10
Los Angeles Angels
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 9, 2026 - MLB

Miami Marlins
8 :  1
Cincinnati Reds

Apr 8, 2026 - MLB

Miami Marlins
7 :  4
Cincinnati Reds

Apr 7, 2026 - MLB

Miami Marlins
3 :  6
Cincinnati Reds

Apr 6, 2026 - MLB

Miami Marlins
0 :  2
Cincinnati Reds

Apr 5, 2026 - MLB

Texas Rangers
1 :  2
Cincinnati Reds

Apr 4, 2026 - MLB

Texas Rangers
0 :  2
Cincinnati Reds

Minnesota Twins against Cincinnati Reds : Head to Head (H2H)

Minnesota Twins

67 %

Cincinnati Reds

33 %

Jun 19, 2025 - MLB

Cincinnati Reds
5 :  12
Minnesota Twins

Jun 18, 2025 - MLB

Cincinnati Reds
4 :  2
Minnesota Twins

Jun 17, 2025 - MLB

Cincinnati Reds
6 :  5
Minnesota Twins

Sep 15, 2024 - MLB

Minnesota Twins
9 :  2
Cincinnati Reds

Sep 20, 2023 - MLB

Cincinnati Reds
3 :  5
Minnesota Twins

Sep 19, 2023 - MLB

Cincinnati Reds
0 :  7
Minnesota Twins

Minnesota Twins - Cincinnati Reds Key Points

  1. Brandon Williamson has an ERA of 5.28
  2. Cincinnati is averaging 3.37 runs per game
  3. Joe Ryan has an ERA of 3.80
  4. Minnesota is averaging 5.42 runs per game

Our Minnesota Twins vs Cincinnati Reds Prediction

Minnesota is the heavy favorite in this game; however, Cincinnati looks to be the best betting option. The Twins’ starter, Ryan, has only been decent this season, as shown by his average ERA. In terms of his splits, he has made just one start at home this season, where he allowed three runs (two earned) over 5.0 innings.

Despite Ryan only being decent, Minnesota has easily been one of the top offenses in the league. They are averaging 5.4 runs per game, the fourth-best mark in the MLB. Because the Twins have a huge advantage in terms of their scoring offense, our Minnesota Twins vs Cincinnati Reds prediction is: Minnesota Twins ML.

Prediction:

 

Minnesota Twins ML

-175
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Minnesota Twins vs Cincinnati Reds Picks