Los Angeles Angels vs Cincinnati Reds Prediction & Picks - MLB

Prediction published on 8/20/25, 6:17 PM  by Lou Aguila | Modified on 8/22/25 at 7:37 AM in MLB Picks

The Cincinnati Reds gun for a sweep in Wednesday’s series finale against the Los Angeles Angels. The Reds, who nabbed a straight-up and ATS win in Games 1 and 2, opened as a surprising +113 underdogs against the team they have beaten in their last 10 meetings.

The Reds’ dominance over the Angels reached another level after capturing their 10th straight head-to-head win following Tuesday’s 6-4 win at Angels Park. Cincinnati, 3.19 ERA in its last five games, got another fantastic start from Hunter Greene, who struck out 12 batters while allowing three runs in 6.1 innings. At 67-60, the Reds are a game outside the NL Wild Card race, trailing the 67-58 NY Mets.

Meanwhile, the Angels plunged to their fourth loss in five games as they once again failed to solve the Reds puzzle. The Angels are averaging 4.1 runs per game on a .233 BA and posting a 6.55 ERA in their last five games. The Angels' starting rotation has given up a horrendous 7.30 ERA, while their bullpen is yielding a slightly uglier 5.59 ERA in this 5-game spell.