Cleveland Guardians vs Cincinnati Reds Prediction & Picks - MLB

USA - MLB

Cleveland Guardians
5/16/26 18:10
Cincinnati Reds

Prediction:

 

Over 7.5 runs.

-145
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 by Stephen Abiola | in MLB Picks

Cleveland Guardians (24-22) and Cincinnati Reds (24-21) will clash in the second game of this series at Progressive Field on Saturday evening. The Guardians opened this three-game home series with a surprising 6-7 defeat on Friday night. Cleveland tried to rally late in the game, but the visitors hung on for a win in the Ohio Cup opener. The Guardians will now be keen to even out this series and improve their abysmal record against the Reds.

Cincinnati Reds, meanwhile, have looked comfortable playing on the road this season, which was evident on Friday night. They got another impressive start from Andrew Abbott while Matt McLain hit a homer to help them get a fully deserved 6-1 lead. However, things went a bit sideways when Ashcraft took the mound in the eighth, allowing the Reds back into the game. It wasn’t an entirely convincing performance from the Reds.

Cleveland Guardians vs Cincinnati Reds Form

Table

Teams Pts P W L
19 Cleveland Guardians
0.487 119 58 61
21 Cincinnati Reds
0.479 117 56 61

Cleveland Guardians and Cincinnati Reds Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 15, 2026 - MLB

Cleveland Guardians
6 :  7
Cincinnati Reds

May 13, 2026 - MLB

Cleveland Guardians
4 :  2
Los Angeles Angels

May 12, 2026 - MLB

Cleveland Guardians
3 :  2
Los Angeles Angels

May 11, 2026 - MLB

Cleveland Guardians
7 :  2
Los Angeles Angels

May 10, 2026 - MLB

Cleveland Guardians
4 :  5
Minnesota Twins

May 9, 2026 - MLB

Cleveland Guardians
1 :  2
Minnesota Twins
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 15, 2026 - MLB

Cleveland Guardians
6 :  7
Cincinnati Reds

May 13, 2026 - MLB

Cleveland Guardians
4 :  2
Los Angeles Angels

May 12, 2026 - MLB

Cleveland Guardians
3 :  2
Los Angeles Angels

May 11, 2026 - MLB

Cleveland Guardians
7 :  2
Los Angeles Angels

May 10, 2026 - MLB

Cleveland Guardians
4 :  5
Minnesota Twins

May 9, 2026 - MLB

Cleveland Guardians
1 :  2
Minnesota Twins
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 7, 2026 - MLB

Kansas City Royals
5 :  8
Cleveland Guardians

May 6, 2026 - MLB

Kansas City Royals
1 :  3
Cleveland Guardians

May 5, 2026 - MLB

Kansas City Royals
5 :  3
Cleveland Guardians

May 4, 2026 - MLB

Kansas City Royals
6 :  2
Cleveland Guardians

May 3, 2026 - MLB

Athletics
7 :  1
Cleveland Guardians

May 2, 2026 - MLB

Athletics
6 :  14
Cleveland Guardians
Cincinnati Reds
Cincinnati Reds Latest matches
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 15, 2026 - MLB

Cleveland Guardians
6 :  7
Cincinnati Reds

May 14, 2026 - MLB

Cincinnati Reds
15 :  1
Washington Nationals

May 13, 2026 - MLB

Cincinnati Reds
7 :  8
Washington Nationals

May 12, 2026 - MLB

Cincinnati Reds
4 :  10
Washington Nationals

May 10, 2026 - MLB

Cincinnati Reds
5 :  0
Houston Astros

May 9, 2026 - MLB

Cincinnati Reds
3 :  1
Houston Astros
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Cincinnati Reds
15 :  1
Washington Nationals

May 13, 2026 - MLB

Cincinnati Reds
7 :  8
Washington Nationals

May 12, 2026 - MLB

Cincinnati Reds
4 :  10
Washington Nationals

May 10, 2026 - MLB

Cincinnati Reds
5 :  0
Houston Astros

May 9, 2026 - MLB

Cincinnati Reds
3 :  1
Houston Astros

May 8, 2026 - MLB

Cincinnati Reds
0 :  10
Houston Astros
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

May 15, 2026 - MLB

Cleveland Guardians
6 :  7
Cincinnati Reds

May 7, 2026 - MLB

Chicago Cubs
8 :  3
Cincinnati Reds

May 6, 2026 - MLB

Chicago Cubs
7 :  6
Cincinnati Reds

May 5, 2026 - MLB

Chicago Cubs
3 :  2
Cincinnati Reds

May 4, 2026 - MLB

Chicago Cubs
5 :  4
Cincinnati Reds

May 3, 2026 - MLB

Pittsburgh Pirates
1 :  0
Cincinnati Reds

Cleveland Guardians against Cincinnati Reds : Head to Head (H2H)

Cleveland Guardians

83 %

Cincinnati Reds

17 %

May 15, 2026 - MLB

Cleveland Guardians
6 :  7
Cincinnati Reds

Mar 22, 2026 - MLB Spring Training

Cleveland Guardians
8 :  2
Cincinnati Reds

Mar 17, 2026 - MLB Spring Training

Cincinnati Reds
6 :  8
Cleveland Guardians

Feb 21, 2026 - MLB Spring Training

Cleveland Guardians
4 :  2
Cincinnati Reds

Jun 11, 2024 - MLB

Cincinnati Reds
3 :  5
Cleveland Guardians

Sep 27, 2023 - MLB

Cleveland Guardians
4 :  3
Cincinnati Reds
Cleveland Guardians vs Cincinnati Reds Picks

Cleveland Guardians - Cincinnati Reds Key Points

  1. The total runs went over in the last four Cincinnati Reds matches.
  2. The total runs went over 7.5 in four of the last five Cleveland Guardians vs Cincinnati Reds clashes.
  3. The total runs went over 7.5 in five of the last eight Cleveland Guardians matches.
  4. The total runs went over 7.5 in the last four Cincinnati Reds matches

Our Cleveland Guardians vs Cincinnati Reds Prediction

Cleveland is the -180 betting favorite, presenting an exciting value. However, we cannot trust them on the moneyline due to their uninspiring head-to-head record. The Guardians lost six of their last seven games against the Reds. Last season, the Reds dominated this fixture, winning five of six. However, they’ll look to make amends today by sending Joey Castillo into the bump. The left-handed pitcher has a solid 3-1 record this season with a 2.98 ERA. He clearly outperforms Chris Paddack, who has a 0-5 record with a high 7.63 ERA. Overall, we see the Guardians running riot in Game 2 with Paddack on the mound.

Our prediction for Cleveland Guardians vs Cincinnati Reds: Over 7.5 runs.

Prediction:

 

Over 7.5 runs.

-145
$150 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.