Chicago White Sox vs Cincinnati Reds Prediction & Picks - MLB
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by Travis Pulver in MLB Picks
The Chicago White Sox (61-56, 36-22 Home) will open a three-game series at home today against the Cincinnati Reds (56-61, 27-30 Away). First Pitch at Rate Field in Chicago, IL, is scheduled for 7:40 p.m. EST on MLB.TV.
Chicago is holding on to a 3.5-game lead in the AL Central but has won just five of their last 10 games. With a 5-3 win over Cleveland on Sunday, they’ve won two in a row. Cincinnati is at the bottom of the NL Central, 17 games back of the Brewers and looking to end a three-game skid.
The White Sox are scheduled to send Sean Burke to the mound to start the day. Burke is 7-6 in 23 appearances (19 starts) this season with a 3.08 ERA and a 1.12 WHIP. Teams have been hitting .222 against him. At home, he has gone 2-4 in 13 appearances (11 starts) with a 3.41 ERA and a .217 OBA
Nick Lodolo is expected to come off the IL to start for the Reds today. He has gone 3-2 in 12 starts with a 4.60 ERA and a 1.47 WHIP. On the road, he is 1-0 with a 3.32 ERA and a .260 OBA.
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Chicago White Sox vs Cincinnati Reds Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
10
|
0.521 | 117 | 61 | 56 |
|
21
|
0.479 | 117 | 56 | 61 |
Chicago White Sox and Cincinnati Reds Latest Matches
2/6 (33%)
4/6 (67%)
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4/6 (67%)
2/6 (33%)
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2/6 (33%)
4/6 (67%)
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3/6 (50%)
3/6 (50%)
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5/6 (83%)
1/6 (17%)
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2/6 (33%)
4/6 (67%)
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Chicago White Sox against Cincinnati Reds : Head to Head (H2H)
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Mar 21, 2026 - MLB Spring Training
Feb 25, 2026 - MLB Spring Training
May 15, 2025 - MLB
Apr 12, 2024 - MLB
Chicago White Sox - Cincinnati Reds Key Points
- Chicago leads the all-time series vs. Cincinnati, 28-19.
- The White Sox are 38-20 ATS (run line) at home; the Reds are 32-25 ATS (run line) on the road.
- The OVER is 32-25-1 for Chicago at home and 30-26-1 for the Reds on the road.
- Betting Public: 84% of run line tickets and 88% of the handle are on the White Sox.
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Our Chicago White Sox vs Cincinnati Reds Prediction
Neither team is hitting the ball well; Chicago has hit .217 and Cincinnati .196. Since we can’t count on either offense to win the game, we have to look at the pitching matchup. In this case, I have to give the edge to Burke. His record is unimpressive, but his stats are solid. Lodolo is going to be a little rusty and doesn’t have a great bullpen backing him up (4.52 ERA).
Our Cincinnati vs. Chicago Pick: White Sox -1.5
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
